Redaktionelt forord: – Internettet er kommet for at blive

Der er ingen tvivl om, at internettet og den medfølgende digitalisering af vores hverdag er kommet for at blive, og at det samtidig har ændret samfundet, borgernes hverdag, velfærdsstaten, den måde der drives virksomhed på, og den måde vi kommunikerer med hinanden på. Det er samtidig så selvfølgeligt, at yngre læsere ikke har nogen erindring om, at det nogensinde har været anderledes, mens mere modne læsere godt kan huske dengang verden var analog. Målet med dette nummer af bladet er at stoppe lidt op og tage bestik af den digitale udvikling og dens betydning på væsentlige områder i det danske samfund. Artiklerne er for de flestes vedkommende indlæg for styrelser og organisationer, der har spillet en central rolle i digitaliseringen af Danmark, og er dermed ikke traditionelle forskningsartikler

Sustav socijalne skrbi i upravljanje ekonomskim rizikom nezaposlenosti: primjer Danske

Članak je posvećen razvoju danskog tržišta rada i politike rada tijekom 1990-ih. U prvom dijelu članka autori objašnjavaju stanje zaštite nezaposlenih početkom 1990- ih i opisuje sustav nezaposlenosti u 1993. Te su godine socijaldemokrati zamijenili konzervativce u danskoj vladi, a njihov je najveći politički prioritet bilo smanjivanje visokih stopa nezaposlenosti. Tako je iduće, 1994. godine započela reforma danskog sustava materijalne pomoći nezaposlenima. Pri kraju prvog dijela članka izlažu se pojedinosti o raspravi vezane za politiku tržišta rada početkom 1990-ih. Drugi dio rada objašnjava razvoj sustava materijalne pomoći u razdoblju od 1994. do 1999. Opisuje se sustav materijalno-pravne pomoći i zamjene dohotka za nezaposlene te navode stope zamjene. Konačno, u trećem se dijelu ocjenjuje razvoj sustava tijekom 1990- ih i buduća kretanja

Programmer for 0-6 årige med forældreinvolvering i dagtilbud. En forskningskortlægning: VIDA-Forskningsserien, 2011:02

Denne rapport er den anden rapport i VIDA-forskningsserien. Rapporten knytter sig således til projektet Vidensbaseret indsats over for udsatte børn i dagtilbud (VIDA-projektet). Projektet belyser overordnet spørgsmålet: Hvordan tager vi i dagtilbuddene bedst hånd om socialt udsatte børn?Det omfattende projekt er bestilt og finansieret af Socialministeriet og udviklet af forskere ved DPU, Aarhus Universitet. Projektet skal udvikle og afprøve samt dokumentere, hvilke pædagogiske indsatser i dagtilbud, der kan sikre udsatte børn en bedre tilværelse

Single-cell imaging of phosphorus uptake shows that key harmful algae rely on different phosphorus sources for growth

Single-cell measurements of biochemical processes have advanced our understanding of cellular physiology in individual microbes and microbial populations. Due to methodological limitations, little is known about single-cell phosphorus (P) uptake and its importance for microbial growth within mixed field populations. Here, we developed a nanometer-scale secondary ion mass spectrometry (nanoSIMS)-based approach to quantify single-cell P uptake in combination with cellular CO2 and N2 fixation. Applying this approach during a harmful algal bloom (HAB), we found that the toxin-producer Nodularia almost exclusively used phosphate for growth at very low phosphate concentrations in the Baltic Sea. In contrast, the non-toxic Aphanizomenon acquired only 15% of its cellular P-demand from phosphate and ~85% from organic P. When phosphate concentrations were raised, Nodularia thrived indicating that this toxin-producer directly benefits from phosphate inputs. The phosphate availability in the Baltic Sea is projected to rise and therefore might foster more frequent and intense Nodularia blooms with a concomitant rise in the overall toxicity of HABs in the Baltic Sea. With a projected increase in HABs worldwide, the capability to use organic P may be a critical factor that not only determines the microbial community structure, but the overall harmfulness and associated costs of algal blooms

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity, which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein-coupled receptors (GPCRs). Here, we uncover an alternate paradigm of GPCR-mediated adipose thermogenesis through the constitutively active receptor, GPR3. We show that the N terminus of GPR3 confers intrinsic signaling activity, resulting in continuous Gs-coupling and cAMP production without an exogenous ligand. Thus, transcriptional induction of Gpr3 represents the regulatory parallel to ligand-binding of conventional GPCRs. Consequently, increasing Gpr3 expression in thermogenic adipocytes is alone sufficient to drive energy expenditure and counteract metabolic disease in mice. Gpr3 transcription is cold-stimulated by a lipolytic signal, and dietary fat potentiates GPR3-dependent thermogenesis to amplify the response to caloric excess. Moreover, we find GPR3 to be an essential, adrenergic-independent regulator of human brown adipocytes. Taken together, our findings reveal a noncanonical mechanism of GPCR control and thermogenic activation through the lipolysis-induced expression of constitutively active GPR3.ISSN:0092-8674ISSN:1097-417