447 research outputs found
Traveling Wave Fronts and Localized Traveling Wave Convection in Binary Fluid Mixtures
Nonlinear fronts between spatially extended traveling wave convection (TW)
and quiescent fluid and spatially localized traveling waves (LTWs) are
investigated in quantitative detail in the bistable regime of binary fluid
mixtures heated from below. A finite-difference method is used to solve the
full hydrodynamic field equations in a vertical cross section of the layer
perpendicular to the convection roll axes. Results are presented for
ethanol-water parameters with several strongly negative separation ratios where
TW solutions bifurcate subcritically. Fronts and LTWs are compared with each
other and similarities and differences are elucidated. Phase propagation out of
the quiescent fluid into the convective structure entails a unique selection of
the latter while fronts and interfaces where the phase moves into the quiescent
state behave differently. Interpretations of various experimental observations
are suggested.Comment: 46 pages, 11 figures. Accepted for publication in Phys. Rev.
Convection in nanofluids with a particle-concentration-dependent thermal conductivity
Thermal convection in nanofluids is investigated by means of a continuum
model for binary-fluid mixtures, with a thermal conductivity depending on the
local concentration of colloidal particles. The applied temperature difference
between the upper and the lower boundary leads via the Soret effect to a
variation of the colloid concentration and therefore to a spatially varying
heat conductivity. An increasing difference between the heat conductivity of
the mixture near the colder and the warmer boundary results in a shift of the
onset of convection to higher values of the Rayleigh number for positive values
of the separation ratio psi>0 and to smaller values in the range psi<0. Beyond
some critical difference of the thermal conductivity between the two
boundaries, we find an oscillatory onset of convection not only for psi<0, but
also within a finite range of psi>0. This range can be extended by increasing
the difference in the thermal conductivity and it is bounded by two
codimension-2 bifurcations.Comment: 13 pages, 11 figures; submitted to Physical Review
Influence of through-flow on linear pattern formation properties in binary mixture convection
We investigate how a horizontal plane Poiseuille shear flow changes linear
convection properties in binary fluid layers heated from below. The full linear
field equations are solved with a shooting method for realistic top and bottom
boundary conditions. Through-flow induced changes of the bifurcation thresholds
(stability boundaries) for different types of convective solutions are deter-
mined in the control parameter space spanned by Rayleigh number, Soret coupling
(positive as well as negative), and through-flow Reynolds number. We elucidate
the through-flow induced lifting of the Hopf symmetry degeneracy of left and
right traveling waves in mixtures with negative Soret coupling. Finally we
determine with a saddle point analysis of the complex dispersion relation of
the field equations over the complex wave number plane the borders between
absolute and convective instabilities for different types of perturbations in
comparison with the appropriate Ginzburg-Landau amplitude equation
approximation. PACS:47.20.-k,47.20.Bp, 47.15.-x,47.54.+rComment: 19 pages, 15 Postscript figure
Bistability of Slow and Fast Traveling Waves in Fluid Mixtures
The appearence of a new type of fast nonlinear traveling wave states in
binary fluid convection with increasing Soret effect is elucidated and the
parameter range of their bistability with the common slower ones is evaluated
numerically. The bifurcation behavior and the significantly different
spatiotemporal properties of the different wave states - e.g. frequency, flow
structure, and concentration distribution - are determined and related to each
other and to a convenient measure of their nonlinearity. This allows to derive
a limit for the applicability of small amplitude expansions. Additionally an
universal scaling behavior of frequencies and mixing properties is found.
PACS: 47.20.-k, 47.10.+g, 47.20.KyComment: 4 pages including 5 Postscript figure
Influence of the Soret effect on convection of binary fluids
Convection in horizontal layers of binary fluids heated from below and in
particular the influence of the Soret effect on the bifurcation properties of
extended stationary and traveling patterns that occur for negative Soret
coupling is investigated theoretically. The fixed points corresponding to these
two convection structures are determined for realistic boundary conditions with
a many mode Galerkin scheme for temperature and concentration and an accurate
one mode truncation of the velocity field. This solution procedure yields the
stable and unstable solutions for all stationary and traveling patterns so that
complete phase diagrams for the different convection types in typical binary
liquid mixtures can easily be computed. Also the transition from weakly to
strongly nonlinear states can be analyzed in detail. An investigation of the
concentration current and of the relevance of its constituents shows the way
for a simplification of the mode representation of temperature and
concentration field as well as for an analytically manageable few mode
description.Comment: 30 pages, 12 figure
Review: ‘Gimme five’: future challenges in multiple sclerosis. ECTRIMS Lecture 2009
This article is based on the ECTRIMS lecture given at the 25th ECTRIMS meeting which was held in Düsseldorf, Germany, from 9 to 12 September 2009. Five challenges have been identified: (1) safeguarding the principles of medical ethics; (2) optimizing the risk/benefit ratio; (3) bridging the gap between multiple sclerosis and experimental autoimmune encephalitis; (4) promoting neuroprotection and repair; and (5) tailoring multiple sclerosis therapy to the individual patient. Each of these challenges will be discussed and placed in the context of current research into the pathogenesis and treatment of multiple sclerosis
Influence of the Dufour effect on convection in binary gas mixtures
Linear and nonlinear properties of convection in binary fluid layers heated
from below are investigated, in particular for gas parameters. A Galerkin
approximation for realistic boundary conditions that describes stationary and
oscillatory convection in the form of straight parallel rolls is used to
determine the influence of the Dufour effect on the bifurcation behaviour of
convective flow intensity, vertical heat current, and concentration mixing. The
Dufour--induced changes in the bifurcation topology and the existence regimes
of stationary and traveling wave convection are elucidated. To check the
validity of the Galerkin results we compare with finite--difference numerical
simulations of the full hydrodynamical field equations. Furthermore, we report
on the scaling behaviour of linear properties of the stationary instability.Comment: 14 pages and 10 figures as uuencoded Postscript file (using uufiles
Amplitude equations for Rayleigh-Benard convective rolls far from threshold
An extension of the amplitude method is proposed. An iterative algorithm is developed to build an amplitude equation model that is shown to provide precise quantitative results even far from the linear instability threshold. The method is applied to the study of stationary Rayleigh-Benard thermoconvective rolls in the nonlinear regime. In particular, the generation of second and third spatial harmonics is analyzed. Comparison with experimental results and direct numerical calculations is also made and a very good agreement is found.Peer reviewe
Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B
Background: We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent manner
The role of versican isoforms V0/V1 in glioma migration mediated by transforming growth factor-β2
Versican is a large chondroitin sulphate proteoglycan produced by several tumour cell types, including high-grade glioma. The increased expression of certain versican isoforms in the extracellular matrix (ECM) plays a role in tumour cell growth, adhesion and migration. Transforming growth factor-β2 (TGF-β2) is an important modulator of glioma invasion, partially by remodeling the ECM. However, it is unknown whether it interacts with versican during malignant progression of glioma cells. Here, we analysed the effect of TGF-β2 on the expression of versican isoforms. The expression of versican V0/V1 was upregulated by TGF-β2 detected by quantitative polymerase chain reaction and immunoprecipitation, whereas V2 was not induced. Using time-lapse scratch and spheroid migration assays, we observed that the glioma migration rate is significantly increased by exogenous TGF-β2 and inhibited by TGF-β2-specific antisense oligonucleotides. Interestingly, an antibody specific for the DPEAAE region of glycosaminoglycan-β domain of versican was able to reverse the effect of TGF-β2 on glioma migration in a dose-dependent manner. Taken together, we report here that TGF-β2 triggers the malignant phenotype of high-grade gliomas by induction of migration, and that this effect is, at least in part, mediated by versican V0/V1
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