The management of acute myocardial infarction in the Russian Federation: Protocol for a study of patient pathways [version 2; referees: 2 approved]

Source at https://doi.org/10.12688/wellcomeopenres.12478.2. Background: Death rates from cardiovascular disease in Russia are among the highest in the world. In recent years, the Russian government has invested substantially in the healthcare system, with a particular focus on improving access to advanced technology, especially for acute myocardial infarction (AMI). This protocol describes a study to understand the management of AMI in different Russian regions, investigating the role of patient, clinical, and health system characteristics. Methods: A prospective observational study has recruited a representative sample of AMI patients within 16 hospitals from 13 regions across Russia. Criteria for inclusion are being aged 35-70 years with a confirmed diagnosis of AMI and surviving until the day after admission. Information being collected includes health system contacts and features of clinical management prior to the event and in the 12 months following discharge from hospital. Following initial exploration of the data to generate hypotheses, multivariate analyses will be applied to assess the role of these characteristics in both treatment decisions and any delays in time critical interventions. Between June 2015 and August 2016, 1,122 patients have been recruited at baseline and follow-up to 12 months post-discharge is scheduled to be completed by autumn 2017. The study is unique in examining patient factors, clinical management prior to admission and in hospital in the acute phase and throughout the critical first year of recovery across a diverse range of geographies and facilities. It uses standardized instruments to collect data from patients and health care providers and includes regions that are diverse in terms of geography and development of cardiology capacity. However, given the limited health services research capacity in the Russian Federation, it was not possible to obtain a sample that was truly nationally representative

(Mechano)synthesis of azomethine- and terpyridine-linked diketopyrrolopyrrole-based polymers

Three efficient synthetic approaches towards new azomethine- and terpyridine-containing 2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (diketopyrrolopyrrole, DPP) based polymers, such as P1 and P2, are reported. The first approach involves the Pd-catalyzed synthesis via two- or three-component Suzuki or Stille cross-coupling reaction in solution. The second approach involves Pd-catalyzed Suzuki cross-coupling reaction under ball-milling conditions. And, finally, the third approach involves Pd-free condensation reaction under ball-milling conditions. The newly obtained polymers exhibited absorbance around 700 nm and emission around 900 nm, and, thus, these polymers are considered to be NIR-fluorophores

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

The study of the influence of stabilizing devices on the pressure pulsations at the free discharge of water through the turbine

The free discharge through the turbine is applied in the course of construction of hydro power plant or in case of excessive water inflow during floods or emergency situations. The experimental and numerical investigation of flow-induced pressure pulsations in hydraulic turbine draft tube at free discharge was performed using a special setup for suppression of draft tube surge. Such special equipment in draft tube cone as fins and “spider”-like units was considered for reducing these pressure pulsations. The paper considers influence of these units on vortex structures and pressure pulsations in the draft tube in several regimes

The study of the influence of stabilizing devices on the pressure pulsations at the free discharge of water through the turbine

The free discharge through the turbine is applied in the course of construction of hydro power plant or in case of excessive water inflow during floods or emergency situations. The experimental and numerical investigation of flow-induced pressure pulsations in hydraulic turbine draft tube at free discharge was performed using a special setup for suppression of draft tube surge. Such special equipment in draft tube cone as fins and “spider”-like units was considered for reducing these pressure pulsations. The paper considers influence of these units on vortex structures and pressure pulsations in the draft tube in several regimes

Experimental study of the effect of air injection on the pressure pulsations in the hydro turbine flow path under different operating conditions

The paper presents an experimental study of oscillatory response in the Francis turbine of hydraulic unit. The experiment was performed on large-scale hydrodynamic test-bench with impeller diameter of 0.3 m. The effect of air injection on the intensity of pressure pulsations was studied at the different regimes in the hydraulic unit. It was revealed that air delivery into the flow path system of the turbine results in almost two-fold reduction of pressure pulsations, but for optimal regimes, there is an increase in pressure pulsations

Experimental study of the effect of air injection on the pressure pulsations in the hydro turbine flow path under different operating conditions

The paper presents an experimental study of oscillatory response in the Francis turbine of hydraulic unit. The experiment was performed on large-scale hydrodynamic test-bench with impeller diameter of 0.3 m. The effect of air injection on the intensity of pressure pulsations was studied at the different regimes in the hydraulic unit. It was revealed that air delivery into the flow path system of the turbine results in almost two-fold reduction of pressure pulsations, but for optimal regimes, there is an increase in pressure pulsations

Experimental study of air delivery into water-conveyance system of the radial-axial turbine

The paper presents an experimental study of oscillatory response in the Francis turbine of hydraulic unit. The experiment was performed on large-scale hydrodynamic test-bench with impeller diameter of 0.3 m. The effect of air injection on the intensity of pressure pulsations was studied at the maximum pressure pulsations in the hydraulic unit. It was revealed that air delivery into the water-conveyance system of the turbine results in almost two-fold reduction of pressure pulsations