Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO Clinical Practice Guidelines

Cardiovascular (CV) toxicity is a potential short- or long-term complication of various anticancer therapies. Some drugs, such as anthracyclines or other biological agents, have been implicated in causing potentially irreversible clinically important cardiac dysfunction. Although targeted therapies are considered less toxic and better tolerated by patients compared with classic chemotherapy agents, rare but serious complications have been described, and longer follow-up is needed to determine the exact profile and outcomes of related cardiac side-effects. Some of these side-effects are irreversible, leading to progressive CV disease, and some others induce reversible dysfunction with no long-term cardiac damage to the patient. Assessment of the prevalence, type and severity of cardiac toxicity caused by various cancer treatments is a breakthrough topic for patient management. Guidelines for preventing, monitoring and treating cardiac side-effects are a major medical need. Efforts are needed to promote strategies for cardiac risk prevention, detection and management, avoiding unintended consequences that can impede development, regulatory approval and patient access to novel therapy. These new ESMO Clinical Practice Guidelines are the result of a multidisciplinary cardio-oncology review of current evidence with the ultimate goal of providing strict criteria-based recommendations on CV risk prevention, assessment, monitoring and management during anticancer treatmen

A New Fuzzy Additive Noise Reduction Method

In this paper we present a new alternative noise reduction method for color images that were corrupted with additive Gaussian noise. We illustrate that color images have to be processed in a different way than most of the state-of-the-art methods. The proposed method consists of two sub-filters. The main concern of the first subfilter is to distinguish between local variations due to noise and local variations due to image structures such as edges. This is realized by using the color component distances instead of component differences as done by most current filters. The second subfilter is used as a complementary filter which especially preserves differences between the color components. This is realized by calculating the local differences in the red, green and blue environment separately. These differences are then combined to calculate the local estimation of the central pixel. Experimental results show the feasibility of the proposed approach

Traceability and Modeling of Requirements in Enterprise Architecture from a Design Rationale Perspective

Contains fulltext : 143774.pdf (preprint version ) (Open Access)IEEE RCIS 2015 : 9th International Conference on Research Challenges in Information Science, May 13-15, 2015, Athens, Greec

EA Anamnesis - A Conceptual Framework for Enterprise Architecture Rationalization

Contains fulltext : 176035.pdf (publisher's version ) (Open Access)Radboud University, 04 april 2017Promotor : Proper, H.A. Co-promotores : Kinderen, S., Ma, Q.XXII, 176 p