Assessment instruments and depression rates in people with spinal cord injury: uma revisão sistemática

Objective: To identify, describe, differentiate and qualify the instruments used to evaluate depression and also identify the percentage and average rates of depression in people with spinal cord injury. Method: This is a systematic review of the literature implementing a qualitative approach. SciELO, LILACS, PubMed and PsycINFO databases were consulted. Original articles were classified according to the variables (Spinal Cord Injury, Depression and Assessment instruments). The studies are presented according to the instruments in recent publications in the past 11 years. Results: Five evaluation instruments were found. PHQ-9, a screening instrument for diagnosing depression was used in most studies, with all being performed in the United States and having a higher impact factor and number of participants. Studies with PHQ-9 presented a total score of people who met the criteria for depression without grading by severity with an average of 17.6% ± 7.3%, while BDI presented 51.6% ± 15.1% and the HADS showed 37.5% ± 31% of people with some degree of depression. Conclusion: This study was important in identifying which instruments can be used to assess depression, the description of each, some of their differences, which ones are used in the best studies and o the depression rates in different parts of the world. It was also important to show how the PHQ-9 is an important instrument, but is limited to being used in the USA

Alterações socioeconômicas e familiares de pacientes com hemiparesia decorrentes de acidente vascular encefálico

O acidente vascular encefálico (AVE) é considerado uma doença de grande impacto social por causar grandes rupturas como a perda do emprego, a diminuição da renda, troca de papéis ocupacionais, podendo se tornar um problema familiar grave. Objetivo: Analisar as alterações no trabalho e família, causadas pela hemiparesia em pacientes que sofreram AVE (Acidente Vascular Encefálico). Métodos: Trata-se de um estudo quantitativo onde participaram trinta pacientes com hemiparesia decorrente de AVE no Hospital de Base de São José do Rio Preto. Os instrumentos utilizados foram a ficha de identificação contendo nome, idade, gênero, profissão atual e profissão anterior entre outras, e questionário adaptado pelo serviço de Terapia Ocupacional com dez questões fechadas, onde o participante tinha opção de resposta ‘’sim’’ ou ‘’não’’. Resultados: A pesquisa mostrou que antes da disfunção física 87% dos participantes trabalhavam e recebiam um salário e após a disfunção nenhum realiza atividade remunerada. As relações familiares dos participantes são mais comprometidas em pacientes que sofreram disfunção a mais tempo do que outros pacientes que possuem a disfunção há menos tempo. Conclusão: Este estudo observou que pacientes com hemiparesia decorrente de AVE podem sofrer alterações nas relações laborais, socioeconômicas e familiares e esses dados são relevantes para que os profissionais de saúde possam auxiliar o retorno desses sujeitos às atividades ocupacionais, após AVE.A stroke is considered a disease of great social impact that causes major disruptions such as job loss, decreased income, and changes in occupational roles; it can become a serious family problem. Objective: To analyze the changes in work and family caused by hemiparesis in patients who have experienced a stroke. Methods: This is a quantitative study involving 30 patients with hemiparesis due to stroke in the Hospital de Base of São José do Rio Preto. The instruments used were the identification form containing their name, age, gender, and current and previous occupation, among other things, along with a questionnaire adapted by the Occupational Therapy service with ten closed questions where the participant could respond either “yes” or “no.” Results: The research showed that before having the stroke, 87% of the participants were working and receiving a salary, and after the stroke none had any paid activity. The family relationships of those impaired for a longer time suffered more than of those who were impaired for a shorter time. Conclusion: This study found that patients with hemiparesis due to stroke may undergo changes in industrial, socioeconomic, and family relationships. This data is relevant so that health professionals can assist the return of these subjects to occupational activities after a stroke

A scoping review

Objective: to map scientific evidence on the extent of tuberculosis in migrants from the international borders between Brazil and the countries of South America. Design: Scoping review of quantitative, qualitative and mixed studies. The research was conducted between February and April 2021. The terms “migrants”, “tuberculosis”, “Brazil”, “Uruguay”, “Paraguay”, “Bolivia”, “Peru”, “British Guiana” “English Guiana”, “French Guiana”, “Suriname”, “Venezuela”, “Argentina”, “Colombia” combined with Boolean operators “AND” and “OR” to identified relevant documents. Studies addressing tuberculosis on migrants from international borders of Brazil were included. Pubmed Central (PMC), LILACS (Scientific and technical literature of Latin America and the Caribbean/BVS), Scopus (Elsevier), Scielo (Scientific Electronic Library Online) and gray literature CAPES thesis database were searched. The study was carried out in three stages where the data was selected and extracted by two independent reviewers for full reading. Results: A total of 705 articles were extracted from the databases chosen for the search, 04 master's dissertations and 01 doctoral thesis. Of these 456 were excluded because they did not meet at least one of the eligibility criteria for this SR and 4 were further excluded because they were duplicates who had not been previously identified. A total of 58 documents were, thus, selected for assessment of the full text. Of these, 40 were further excluded for not meeting at least one of the eligibility criteria. A total of 18 studies were included for data collection: 15 articles, 2 master's dissertations and 1 doctoral thesis, produced between 2002 and 2021. Conclusion: This scoping review mapped the existing evidence on tuberculosis at the international borders of Brazil and on access of immigrants with tuberculosis to health services in Brazil. Descriptors: tuberculosis; immigrants; public health surveillance; epidemiological surveillance; sanitary control of borders; health services accessibility.publishersversionpublishe

Immunological response in mice bearing LM3 breast tumor undergoing Pulchellin treatment

Background: Ribosome-inactivating proteins (RIP) have been studied in the search for toxins that could be used as immunotoxins for cancer treatment. Pulchellin, a type 2 RIP, is suggested to induce immune responses that have a role in controlling cancer. Methods: The percentage of dendritic cells and CD4+ and CD8+ T cells in the spleen (flow cytometry), cytokines’ release by PECs and splenocytes (ELISA) and nitric oxide production by PECs (Griess assay) were determined from tumor-bearing mice injected intratumorally with 0.1 ml of pulchellin at 0.75 μg/kg of body weight. Statistical analysis was performed by one-way ANOVA with Tukey’s post hoc test. Results: Pulchellin-treated mice showed significant immune system activation, characterized by increased release of IFN-γ and Th2 cytokines (IL-4 and IL-10), while IL-6 and TGF-β levels were decreased. There was also an increase in macrophage’s activation, as denoted by the higher percentage of macrophages expressing adhesion and costimulatory molecules (CD54 and CD80, respectively). Conclusions: Our results suggest that pulchellin is promising as an adjuvant in breast cancer treatment.Fil: de Matos, Djamile Cordeiro. Universidade de Sao Paulo; BrasilFil: Abreu de Ribeiro, Livia Carolina. Universidade de Sao Paulo; BrasilFil: Tansini, Aline. Universidade de Sao Paulo; BrasilFil: Ferreira, Lucas Souza. Universidade de Sao Paulo; BrasilFil: Polesi Placeres, Marisa Campos. Universidade de Sao Paulo; BrasilFil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Iracilda Zeppone, Carlos. Universidade de Sao Paulo; Brasi

The relation between anxiety and depression and the loss of the occupational roles of patients with spinal cord injury

O estudo objetivou analisar sintomas ansiedade e depressão em pacientes com lesão medular e investigar sua correlação com a incidência da perda dos papéis ocupacionais, bem como as estratégias adotadas por profissionais da saúde para a promoção de saúde mental a essa população. Trata-se de um estudo correlacional de corte transversal, com abordagem predominantemente quantitativa, sendo uma etapa qualitativa. Para a coleta de dados, foram utilizados os seguintes instrumentos: Ficha de Identificação; Inventário de Depressão de Beck (IDB); Inventário de Ansiedade Traço-Estado (IDATE); Critério de Classificação Econômica do Brasil (CCEB); Lista de Identificação de Papéis Ocupacionais (LIPO); e entrevistas semiestruturadas com profissionais do Serviço de Atendimento Domiciliar (SAD). Participaram do estudo 30 pacientes com lesão medular traumática atendidos no referido serviço, de ambos os sexos, entre 19 anos e 72 anos de idade, e 10 profissionais da saúde do SAD. Para a análise estatística da etapa quantitativa, utilizou-se o programa IBM SPSS Statistic versão 25, e na etapa qualitativa, a Análise de Conteúdo de Bardin. Os resultados identificaram média de escores de sintomas de ansiedade média e depressão leve/moderada entre os participantes, sendo que a variável significantemente associada à depressão foi apenas o estado civil; já a variável associada à ansiedadeestado foi o apoio familiar, e à ansiedade-traço, as atividades de autocuidado. Os papéis que sofreram mais perdas foram os de trabalhador e passatempo/amador, e aqueles considerados menos importantes, de estudante e participação em organizações. Importância maior foi atribuída pelos participantes aos papéis de membro da família, amigo, trabalhador e religioso, sendo os dois primeiros os mais desempenhados no passado, presente e com pretensão no futuro. Identificou-se relação entre ansiedade e depressão e perdas de papéis ocupacionais, de modo que aqueles que vivenciaram mais perdas apresentaram mais sintomas de ansiedade e depressão, e aqueles que continuaram exercendo mais papéis após a lesão apresentaram menos sintomas de ansiedade e depressão. Os resultados da etapa qualitativa e referentes às entrevistas com os profissionais evidenciaram a construção de sete categorias analíticas e 12 categorias empíricas. A análise das categorias permitiu verificar que as estratégias adotadas pelos profissionais de saúde para a promoção de saúde mental a essa população ainda se encontram limitadas, dada a ausência de serviços especializados e o difícil encaminhamento para profissionais da área. Além disso, a falta de posturas sociais mais benevolentes para com essa população acentua a dificuldade de assegurar acessibilidade e oportunidades mais igualitárias a essas pessoas. Considera-se necessário conferir maior atenção à associação de doenças físicas a quadros psiquiátricos, visto que perder ou resgatar um papel desempenhado anteriormente pode não estar relacionado apenas à disfunção física, mas também a um quadro psíquicoThe study´s aim was to analyze anxiety and depression symptoms in patients with spinal cord injury, their correlation with the incidence of the loss of occupational roles and what was the exist strategies of health professionals to promote their mental health. This research is based on the correlation between cross-section and a quantitative approach predominantly, this being a qualitative stage. The instruments used for evaluation were: Identification Card; Beck Depression Inventory (IDB); TraitState Anxiety Inventory (IDATE); Brazilian Economic Classification Criteria (CCEB); Identification List of the Occupational Roles (LIPO) and semi-structured interview with the of the Home Care Service´s professionals (SAD). A total of 30 subjects with traumatic spinal cord injury, had participated, both male and female, aged 19 years and 72 years, attended by SAD, and also 10 health service professionals in the study. For the statistical analysis the quantitative´s stage, the IBM SPSS Statistics version 25 program was used, in the qualitative step the Bardin Content Analysis was used. The results has identified a average symptoms of medium anxiety and mild to moderate depression scores among participants, in which the variable significantly associated with depression was related only the marital status; the variable associated with anxiety-state was correlated with family support and the anxiety-trait self-care with activities. The roles who suffered the most losses were the roles of worker and hobbyist /amateur. The roles who was considered less important were student and participation in organizations; the most important roles were family member, friend, worker and religious, the first two were the ones most played in the past, present and as a future ambition. We had identify the connexion between anxiety and depression with occupational roles´s loss, in which those who had with more losses they showed more anxiety and depression symptoms and those who continued to have varied roles after the injury presented fewer symptoms of anxiety and depression. According with the results of the qualitative stage, relative to the interviews with the professionals, seven analytical categories were found and 12 empirical categories were deployed. The analysis of the categories has allowed to verify that the strategies for the mental health´s promotion in this population are limited yet, since, there are not specialized services and the referencing to area specialty professional is difficult to access, besides, the lack of social attitudes to benefit this population which corroborate the with the difficulty in their accessibility and opportunities. More attention are needed regarding the association of physical diseases with psychiatric conditions, since the loss of a role played or the recovery of it, may not be related only to physical dysfunction, but also to psychic dysfunctio

Immunological response in mice bearing LM3 breast tumor undergoing Pulchellin treatment

<p>Abstract</p> <p>Background</p> <p>Ribosome-inactivating proteins (RIP) have been studied in the search for toxins that could be used as immunotoxins for cancer treatment. Pulchellin, a type 2 RIP, is suggested to induce immune responses that have a role in controlling cancer.</p> <p>Methods</p> <p>The percentage of dendritic cells and CD4⁺ and CD8⁺ T cells in the spleen (flow cytometry), cytokines’ release by PECs and splenocytes (ELISA) and nitric oxide production by PECs (Griess assay) were determined from tumor-bearing mice injected intratumorally with 0.1 ml of pulchellin at 0.75 μg/kg of body weight. Statistical analysis was performed by one-way ANOVA with Tukey’s post hoc test.</p> <p>Results</p> <p>Pulchellin-treated mice showed significant immune system activation, characterized by increased release of IFN-γ and Th2 cytokines (IL-4 and IL-10), while IL-6 and TGF-β levels were decreased. There was also an increase in macrophage’s activation, as denoted by the higher percentage of macrophages expressing adhesion and costimulatory molecules (CD54 and CD80, respectively).</p> <p>Conclusions</p> <p>Our results suggest that pulchellin is promising as an adjuvant in breast cancer treatment.</p