112 research outputs found
Rubella (German measles)
This issue of eMedRef provides information to clinicians on the pathophysiology, diagnosis, and therapeutics of rubella
Erythema infectiosum (Fifth Disease)
This issue of eMedRef provides information to clinicians on the pathophysiology, diagnosis, and therapeutics of erythema infectiosum
Measles (Rubeola)
This issue of eMedRef provides information to clinicians on the pathophysiology, diagnosis, and therapeutics of the measles
Roseola
This issue of eMedRef provides information to clinicians on the pathophysiology, diagnosis, and therapeutics of roseola
Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA
We characterised the human hSuv3p protein belonging to the family of NTPases/helicases. In yeast mitochondria the hSUV3 orthologue is a component of the degradosome complex and participates in mtRNA turnover and processing, while in Caenorhabditis elegans the hSUV3 orthologue is necessary for viability of early embryos. Using immunofluorescence analysis, an in vitro mitochondrial uptake assay and subāfractionation of human mitochondria we show hSuv3p to be a soluble protein localised in the mitochondrial matrix. We expressed and purified recombinant hSuv3p protein from a bacterial expression system. The purified enzyme was capable of hydrolysing ATP with a Km of 41.9 ĀµM and the activity was only modestly stimulated by polynucleotides. hSuv3p unwound partly hybridised dsRNA and dsDNA structures with a very strong preference for the latter. The presented analysis of the hSuv3p NTPase/helicase suggests that new functions of the protein have been acquired in the course of evolution
Looking at Vector Space and Language Models for IR using Density Matrices
In this work, we conduct a joint analysis of both Vector Space and Language
Models for IR using the mathematical framework of Quantum Theory. We shed light
on how both models allocate the space of density matrices. A density matrix is
shown to be a general representational tool capable of leveraging capabilities
of both VSM and LM representations thus paving the way for a new generation of
retrieval models. We analyze the possible implications suggested by our
findings.Comment: In Proceedings of Quantum Interaction 201
Concepts and Their Dynamics: A Quantum-Theoretic Modeling of Human Thought
We analyze different aspects of our quantum modeling approach of human
concepts, and more specifically focus on the quantum effects of contextuality,
interference, entanglement and emergence, illustrating how each of them makes
its appearance in specific situations of the dynamics of human concepts and
their combinations. We point out the relation of our approach, which is based
on an ontology of a concept as an entity in a state changing under influence of
a context, with the main traditional concept theories, i.e. prototype theory,
exemplar theory and theory theory. We ponder about the question why quantum
theory performs so well in its modeling of human concepts, and shed light on
this question by analyzing the role of complex amplitudes, showing how they
allow to describe interference in the statistics of measurement outcomes, while
in the traditional theories statistics of outcomes originates in classical
probability weights, without the possibility of interference. The relevance of
complex numbers, the appearance of entanglement, and the role of Fock space in
explaining contextual emergence, all as unique features of the quantum
modeling, are explicitly revealed in this paper by analyzing human concepts and
their dynamics.Comment: 31 pages, 5 figure
PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria
Polyadenylation of mRNA in human mitochondria is crucial for gene expression and perturbation of poly(A) tail length has been linked to a human neurodegenerative disease. Here we show that 2ā²-phosphodiesterase (2ā²-PDE), (hereafter PDE12), is a mitochondrial protein that specifically removes poly(A) extensions from mitochondrial mRNAs both in vitro and in mitochondria of cultured cells. In eukaryotes, poly(A) tails generally stabilize mature mRNAs, whereas in bacteria they increase mRNA turnover. In human mitochondria, the effects of increased PDE12 expression were transcript dependent. An excess of PDE12 led to an increase in the level of three mt-mRNAs (ND1, ND2 and CytB) and two (CO1 and CO2) were less abundant than in mitochondria of control cells and there was no appreciable effect on the steady-state level of the remainder of the mitochondrial transcripts. The alterations in poly(A) tail length accompanying elevated PDE12 expression were associated with severe inhibition of mitochondrial protein synthesis, and consequently respiratory incompetence. Therefore, we propose that mRNA poly(A) tails are important in regulating protein synthesis in human mitochondria, as it is the case for nuclear-encoded eukaryotic mRNA
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