Brain connectivity changes after osteopathic manipulative treatment: A randomized manual placebo-controlled trial

The effects of osteopathic manipulative treatment (OMT) on functional brain connectivity in healthy adults is missing in the literature. To make up for this lack, we applied advanced network analysis methods to analyze resting state functional magnetic resonance imaging (fMRI) data, after OMT and Placebo treatment (P) in 30 healthy asymptomatic young participants randomized into OMT and placebo groups (OMTg; Pg). fMRI brain activity measures, performed before (T0), immediately after (T1) and three days after (T2) OMT or P were used for inferring treatment effects on brain circuit functional organization. Repeated measures ANOVA and post-hoc analysis demonstrated that Right Precentral Gyrus (F (2, 32) = 5.995, p < 0.005) was more influential over the information flow immediately after the OMT, while decreased betweenness centrality in Left Caudate (F (2, 32) = 6.496, p < 0.005) was observable three days after. Clustering coefficient showed a distinct time-point and group effect. At T1, reduced neighborhood connectivity was observed after OMT in the Left Amygdala (L-Amyg) (F(2, 32) = 7.269, p < 0.005) and Left Middle Temporal Gyrus (F(2, 32) = 6.452, p < 0.005), whereas at T2 the L-Amyg and Vermis-III (F(2, 32) = 6.772, p < 0.005) increased functional interactions. Data demonstrated functional connectivity re-arrangement after OMT

Vulnerability assessment of concrete bridges using different methods of visual inspection

This paper shows the comparisons between different methods of visual inspection used in European Countries. These methodologies are applied to the deck bridge located near Cagliari, along the SS 195 road to Capoterra. From a strategic point of view, this structure plays a key role ensuring a direct connection to different structures related to industrial and local productions and to an important touristic district. This is a prestressed concrete bridge in an aggressive marine environment, which in October 2008 was hit by a flood that caused subsidence in the foundations. The aim of our inspection is to obtain a real measure of the vulnerability through different procedures and to determine which is the best method able to give objective results

Food waste as a (negative) measure of social capital. A study across Italian Provinces

Household food waste is a crucial problem in developed countries. Food waste behaviour is the result of complex interactions among economic factors, deeply rooted habits, and social norms. It can thus be considered a measure of the social capital characterizing a community. We test this hypothesis using a national-level dataset on household food-related behaviours and opinions in Italy gathered in 2016. This country is an ideal test bed for a comparative analysis on social capital. We find household food waste measures to be negatively related with the local level of social capital. This relationship is mediated by family income, as it becomes weaker for better-off families. Furthermore, we find that behaviours and opinions eliciting status concerns with respect to food, as well as lack of organisational abilities, generate increased food waste. In turn, these behaviours and opinions are more prevalent in areas with low social capital. Our results, captured by a simple model where food waste decisions are considered in the context of a modified public good game, allow to derive several policy implications for the reduction of food waste

Correlated electron-hole plasma in organometal perovskites

Organic-inorganic perovskites are a class of solution-processed semiconductors holding promise for the realization of low-cost efficient solar cells and on-chip lasers. Despite the recent attention they have attracted, fundamental aspects of the photophysics underlying device operation still remain elusive. Here we use photoluminescence and transmission spectroscopy to show that photoexcitations give rise to a conducting plasma of unbound but Coulomb-correlated electron-hole pairs at all excitations of interest for light-energy conversion and stimulated optical amplification. The conductive nature of the photoexcited plasma has crucial consequences for perovskite-based devices: in solar cells, it ensures efficient charge separation and ambipolar transport while, concerning lasing, it provides a low threshold for light amplification and justifies a favourable outlook for the demonstration of an electrically driven laser. We find a significant trap density, whose cross-section for carrier capture is however low, yielding a minor impact on device performance

The agroforestry heritage system of Sabana De Morro in El Salvador

Traditional agroforestry systems are recognized as having great importance for providing multiple benefits for local communities all over the world, especially in tropical countries. Thanks to their multifunctional role, they can support small farmers, contribute to hydrogeological risk reduction, water regulation, preservation of soil, agrobiodiversity and landscape, as well as being examples of mitigation and adaptation towards climate change. The Globally Important Agricultural Heritage Systems (GIAHS) programme of the Food and Agriculture Organization (FAO) aims to identify agricultural systems of global importance, preserving landscape, agrobiodiversity and traditional knowledge, through dynamic conservation principles. The Sabana de Morro is a traditional agroforestry system located in El Salvador based on cattle grazing in pastures with the presence of Crescentia alata and Crescentia cujete trees, locally called Morro or Jícaro. We documented the main characteristics of this system, that has never been deeply studied, in the Municipality of Dolores, in accordance with the five GIAHS criteria, and through detailed land use mapping, to assess the relations between landscape structure, agrobiodiversity and traditional silvopastoral practices. Sabana de Morro proved to be based on strong interactions between trees, cattle and farmers. The pulp of the Morro fruits is eaten by grazing cattle, completing their feeding and giving a peculiar taste to the locally produced cheese. Morro trees provide shade for the animals while cattle contribute by spreading their seeds that also take advantage of the manure. Results show that this agroforestry system contributes to the preservation of a rich agrobiodiversity and of the traditional landscape. At the same time, it supports local farmers’ livelihood and is consistent with the aim of the GIAHS programme, even if further surveys and research are needed to assess the real possibility of the inclusion in this FAO programme

BAT2 and BAT3 polymorphisms as novel genetic risk factors for rejection after HLA-related SCT.

The genetic background of donor and recipient is an important factor determining the outcome of allogeneic hematopoietic SCT (allo-HSCT). We applied whole-genome analysis to investigate genetic variants - other than HLA class I and II - associated with negative outcome after HLA-identical sibling allo-HSCT in a cohort of 110 β-Thalassemic patients. We identified two single-nucleotide polymorphisms (SNPs) in BAT2 (A/G) and BAT3 (T/C) genes, SNP rs11538264 and SNP rs10484558, both located in the HLA class III region, in strong linkage disequilibrium between each other (R2 =0.92). When considered as single SNP, none of them reached a significant association with graft rejection (nominal P<0.00001 for BAT2 SNP rs11538264, and P<0.0001 for BAT3 SNP rs10484558), whereas the BAT2/BAT3 A/C haplotype was present at significantly higher frequency in patients who rejected as compared to those with functional graft (30.0% vs 2.6%, nominal P=1.15 × 10-8; and adjusted P=0.0071). The BAT2/BAT3 polymorphisms and specifically the A/C haplotype may represent a novel immunogenetic factor associated with graft rejection in patients undergoing allo-HSCT

2-Methyl-β-cyclodextrin grafted ammonium chitosan: synergistic effects of cyclodextrin host and polymer backbone in the interaction with amphiphilic prednisolone phosphate salt as revealed by NMR spectroscopy

Reduced molecular weight chitosan was quaternized with 2-chloro-N,N-diethylethylamine to obtain a water soluble derivative (N+-rCh). Methylated-β-cyclodextrin (MCD), with 0.5 molar substitution, was covalently linked to N+-rCh through 1,6-hexamethylene diisocyanate spacer to give the derivatized ammonium chitosan N+-rCh-MCD. To shed light on the role of the cyclodextrin pendant in guiding binding interactions with amphiphilic active ingredients, corticosteroid prednisolone phosphate salt (PN) was considered. The deep inclusion of PN into cyclodextrin in PN/MCD model system was pointed out by analysis of 1H NMR complexation shifts, 1D ROESY spectra, and diffusion measurements (DOSY). By using proton selective relaxation rates measurements as investigation tool, the superior affinity of N+-rCh-MCD towards PN was demonstrated in comparison with parent ammonium chitosan N+-rCh

Dealing With COVID-19 Patients: A Moderated Mediation Model of Exposure to Patients' Death and Mental Health of Italian Health Care Workers

Introduction: The COVID-19 pandemic is asking health care workers (HCWs) to meet extraordinary challenges. In turn, HCWs were experiencing tremendous psycho-social crisis as they have had to deal with unexpected emotional requirements (ERs) arising from caring for suffering and dying patients on a daily basis. In that context, recent studies have highlighted how HCWs working during the COVID-19 outbreak manifested extreme emotional and behavioral reactions that may have impacted their mental health, increasing the risk for developing post-traumatic stress symptoms. Purpose: The aim of the study was to investigate post-traumatic stress symptoms, such as intrusion symptoms, as a potential mediator of the link between ERs and crying at work, and whether rumination moderates the relationship between ERs and intrusion-based PTS symptoms among HCWs who have had to deal with patients dying from COVID-19. Methods: An online cross-sectional study design was performed. A total of 543 Italian HCWs (physicians and nurses) participated in the study. Participation was voluntary and anonymous. We used the SPSS version of bootstrap-based PROCESS macro for testing the moderated mediation model. Results: ERs had an indirect effect on crying at work through the mediating role of intrusion symptoms. Results from the moderated mediation model showed that rumination moderated the indirect effect of ERs on crying at work via intrusion symptoms, and this effect was significant only for high rumination. Furthermore, when we tested for an alternative model where rumination moderates the direct effect of ERs on crying at work, this moderation was not significant. Conclusions: As the second wave of the COVID-19 pandemic is ongoing, there is an urgent need for decision-makers to rapidly implement interventions aimed at offering timely psychological support to HCWs, especially in those contexts where the risk of emotional labor associated to patients dying from COVID-19 is higher

LASER-VISUAL-INERTIAL ODOMETRY BASED SOLUTION FOR 3D HERITAGE MODELING: THE SANCTUARY OF THE BLESSED VIRGIN OF TROMPONE

Abstract. The advent of new mobile mapping systems that integrate different sensors has made it easier to acquire multiple 3D information with high speed. Today, technological development has allowed the creation of portable systems particularly suitable for indoor surveys, which mainly integrating LiDAR devices, chambers and inertial platforms, make it possible to create in a fast and easy way, full 3D model of the environment. However, the performance of these instruments differs depending on the acquisition context (indoor and outdoor), the characteristics of the scene (for example lighting, the presence of objects and people, reflecting surfaces, textures) and, above all, the mapping and localization algorithms implemented in devices. The purpose of this study is to analyse the results, and their accuracy, deriving from a survey conducted with the KAARTA Stencil 2 handheld system. This instrument, composed of a 3D LiDAR Velodyne VLP-16, a MEMS inertial platform and a feature tracker camera, it is able to realize the temporal 3D map of the environment. Specifically, the acquisition tests were carried out in a context of metrical documentation of an architectural heritage, in order extract architectural detail for the future reconstruction of virtual and augmented reality environments and for Historical Building Information Modeling purposes. The achieved results were analysed and the discrepancies from some reference LiDAR data are computed for a final evaluation. The system was tested in the church and cloister of the Sanctuary of the Beata Vergine del Trompone in Moncrivello (VC) (Italy).</p

Concerns, Perceived Impact, Preparedness in Coronavirus Disease (COVID-19) Pandemic and Health Outcomes among Italian Physicians: A Cross-Sectional Study

Background: Health care workers (HCWs) are among the professionals at serious risk for the impact of the COVID-19 pandemic on their mental health. In this sense, the next public health challenge globally will be to preserving healthy HCWs during this pandemic. Aim: The present study has the aim of investigating the relationship among concerns, perceived impact, preparedness for the COVID-19 pandemic and the mental health of Italian physicians. Methods: From March 29th to April 15th 2020, we conducted an online survey using snowball sampling techniques through Limesurvey platform. Data were analyzed using descriptive statistics and multiple binary logistic regressions. Results: Multivariate analysis showed that the risk factors for perceived job stress were concerns about catching COVID-19 (OR = 3.18 [95% CI = 2.00-5.05] P &lt;.001), perceived impact on job demands (OR = 1.63 [95% CI = 1.05-2.52] P &lt;.05), perceived impact on job role (OR = 2.50 [95% CI = 1.60-3.90] P &lt;.001), and non-working concerns (OR = 1.86 [95% CI = 1.15-3.03] P &lt;.05). With respect to the risk factors for rumination about the pandemic emerged concerns about catching COVID-19 (OR 1.74, [95% CI = 1.12-2.71] P &lt;.05), perceived impact on job role (OR = 1.68 [95% CI = 1.12-2.52] P &lt;.05), and impact on personal life (OR = 2.04 [95% CI = 1.08-3.86] P &lt;.05). Finally, the risk factors for crying at work were perceived impact on job role (OR = 2.47, [95% CI = 1.20-5.09] P &lt;.05), rumination about the pandemic (OR = 3.027 [95% CI = 1.27-7.19] P &lt;.01), watching colleagues crying at work (OR = 3.82 [95% CI = 1.88-7.77] P &lt;.01), and perceived job stress (OR = 3.53 [95% CI = 1.24-10.07] P &lt;.05). Conclusion: In general, our results highlighted that being concerned about being infected/infecting other people, carrying out new and unusual tasks, and witnessing colleagues crying at work were important risk factors for physicians’ well-being. Additional data are necessary to advance understanding of these risk factors in a long-term perspective