Increase in pediatric recurrent fever evaluations during the first year of the COVID-19 pandemic in North America

The impact of the COVID-19 pandemic on new diagnoses of recurrent fevers and autoinflammatory diseases is largely unknown. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) PFAPA/AID Working Group aimed to investigate the impact of the COVID-19 pandemic on the number of pediatric patients evaluated for recurrent fevers and autoinflammatory diseases in North America. The absolute number of new outpatient visits and the proportion of these visits attributed to recurrent fever diagnoses during the pre-pandemic period (1 March 2019–29 February 2020) and the first year of the COVID-19 pandemic (1 March 2020–28 February 2021) were examined. Data were collected from 27 sites in the United States and Canada. Our results showed an increase in the absolute number of new visits for recurrent fever evaluations in 21 of 27 sites during the COVID-19 pandemic compared to the pre-pandemic period. The increase was observed across different geographic regions in North America. Additionally, the proportion of new visits to these centers for recurrent fever in relation to all new patient evaluations was significantly higher during the first year of the pandemic, increasing from 7.8% before the pandemic to 10.9% during the pandemic year (p < 0.001). Our findings showed that the first year of the COVID-19 pandemic was associated with a higher number of evaluations by pediatric subspecialists for recurrent fevers. Further research is needed to understand the reasons behind these findings and to explore non-infectious triggers for recurrent fevers in children

Matrix effects on organic pollutants analysis in marine sediment

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Aliphatics hydrocarbon content in surface sediment from Jakarta Bay, Indonesia

10th Joint Conference on Chemistry, Solo, INDONESIA, SEP 08-09, 2015International audienceSedimentary aliphatic hydrocarbons content have been studied quantitatively and qualitatively using GC/MS method in eight coastal stations located in the Jakarta Bay, North of Jakarta, Indonesia. The total concentrations n-alkanes have ranged from 480 mu g.kg(-1) to 1,935 mu g.kg(-1) sediment dry weight. Several ratios (e.g. CPI24-32, NAR, TAR, Pr/Phy, n-C-17/Pr, n-C-18/Phyt, n-C-29/n-C-17, Sigma n-alkanes/n-C16LMW/HMW, Paq and TMD) were used to evaluate the possible sources of terrestrial-marine inputs of these hydrocarbons in the sediments. The various origins of aliphatic hydrocarbons were generally biogenic, including both terrigenous and marine, with an anthropogenic pyrolytic contribution (petrogenic and biogenic combustion). Two stations (G,H) were thehighest concentration and had potential risk to environmen

Distributions and sources of persistent organic pollutants (aliphatic hydrocarbons, PAHs, PCBs and pesticides) in surface sediments of an industrialized urban river (Huveaune), France

International audienceSurface sediments from the Huveaune River were analyzed for n-alkanes, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), organochlorine and organophosphorous pesticides (OCs and OPs) by using gas chromatography-mass spectrometry (GC-MS). Concentrations of total alkanes ranged from 184 to 26,780 mu g.kg(-1) sediment dry weight (dw) with a mean concentration of 6126 +/- 8006 mu g-kg(-1) dw, concentrations of total PAHs ranged from 572 to 4235 mu g.kg(-1) dw with a mean concentration of 1966 +/- 1104 mu g.kg(-1) dw, concentrations of total PCB ranged from 2.8 to 435 mu g.kg(-1) dw with a mean concentration of 148 164 mu g.kg(-1) dw and concentrations of total pesticides ranged from 0.07 to 1.25 mu g.kg(-1) dw with a mean concentration of 1.23 +/- 1.29 mu g.kg(-1) dw. The spatial distribution of POPs reveals that pollutant concentration is relatively higher at the mouth of the river. The molecular indices of specific n-alkanes (CPI, NAR and TAR) and molecular indices of PAHs (Ant/(Ant + Phe), Fl/(Fl + Pyr), BaA/(BaA + Chry), IPyr/(Ipyr + BghiP)) were calculated to evaluate the possible sources of hydrocarbons. These molecular indices suggest mainly pyrolytic inputs which are markedly biogenic. All contaminant levels were also compared with Sediments Quality Guidelines (SQG) showing that the contamination levels in all stations were most of the time lower than their respective SQG. While, for PCBs, five stations (H5, F16,H7, HE and H9) were higher than their effect range median (ERM) values which may indicate high potential toxicity of the sediment with probable adverse effects to the living biota. (c) 2014 Elsevier B.V. All rights reserved

De novo unbalanced t(11q;21q) leading to a partial monosomy 21pter-q22.2 and 11q24-qter in a patient initially diagnosed as monosomy 21

We describe a patient in whom full monosomy 21 was initially assumed from routine GTG banded karyotyping. Re-examination with chromosome painting demonstrated an unbalanced translocation between the long arms of chromosomes 11 and 21. Fluorescence in situ hybridization (FISH) and microsatellite marker analysis revealed partial monosomy of chromosome 21 (pter-q22.2) and 11 (q24-qter). The patient was prematurely born in the 31st week of gestation and expired 3 days after delivery. She showed multiple minor anomalies, a complex cardio-vascular malformation, intestinal malrotation and cerebellar hypoplasia

Early Differentiation of Pseudoprogression for Recurrent Glioblastoma in STERIMGLI Trial Using Multimodal MRI Radiomics Signature

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Predicted and measured concentrations of venlafaxine and its metabolites in a coastal zone receiving treated wastewaters.

International audienceParent compounds and metabolites excreted in wastewater are inconstantly eliminated in WTPs and therefore are rejected mainly in surface water. However, the coastal environment suffers from pollution generated by inland activities which discharge their wastes into the sea via streams, rivers and wastewater marine outfalls. The low levels reported in the marine environment encourage the development of adapted methodologies to estimate predicted environmental concentrations (PECs). In the present work, the occurrence of VLF and its major human metabolites was investigated at a Mediterranean coastal site directly impacted by a submarine outfall. Concentrations of VLF and its metabolites were measured in the different compartments i.e. in water with passive sampler, sediment and mussels. Predicted concentrations of VLF and its main human metabolites were estimated in seawater taking into account the sold amounts of VLF, its human metabolism and the diffusion and dilution of the compounds in the coastal zone using an adapted hydrodynamic model (MARS 3D) developed by Ifremer. In seawater, estimated concentrations were in a good agreement with measured levels. Moreover, concentrations in mussels were estimated using concentrations estimated in seawater and a bioconcentration factor (BCF) linear model described in the literature for marine mussels. Estimated concentrations in biota were then compared to the concentrations in mussels detected at the studied site. Concentrations estimated with the BCF model were overestimated compared to measured concentrations, which could be explained by a possible metabolism of these compounds by mussels, not taken into account in the estimations. Moreover, attenuation mechanisms such as sorption on suspended matter could explain a lower availability of compounds for mussels in the water column and a lower bioconcentration in organisms than those expected. Studies on sorption mechanismsand metabolism of these compounds in mussels should be further performed, in order to improve these estimations. As organisms are long-term exposed to low concentrations of pharmaceuticals, possible effects could be observed. The use of sensitive approaches, such as “omics” approaches, already used for other pollutants such as heavy metals, could help obtain this information

Efficacy of scalp hair decontamination following exposure to vapours of sulphur mustard simulants 2-chloroethyl ethyl sulphide and methyl salicylate

International audienceChemical warfare agents are an actual threat and victims' decontamination is a main concern when mass exposure occurs. Skin decontamination with current protocols has been widely documented, as well as surface decontamination. However, considering hair ability to trap chemicals in vapour phase, we investigated hair decontamination after exposure to sulphur mustard simulants methyl salicylate and 2-chloroethyl ethyl sulphide. Four decontamination protocols were tested on hair, combining showering and emergency decontamination (use of Fuller's earth or Reactive Skin Decontamination Lotion RSDL ®). Both simulants were recovered from hair after treatment, but contents were significantly reduced (42 e85% content allowance). Showering alone was the least efficient protocol. Concerning 2-chloroethyl ethyl sulphide, protocols did not display significant differences in decontamination efficacy. For MeS, use of emergency decontaminants significantly increased showering efficacy (10e20% rise), underlining their usefulness before thorough decontamination. Our results highlighted the need to extensively decontaminate hair after chemical exposure. Residual amounts after decontamination are challenging, as their release from hair could lead to health issues

Erratum à « Proposition de délinéation des volumes cibles tumoraux et sélection des aires ganglionnaires des cancers de la glande parotide » report [Cancer Radiother. 23 (2019) 255–263]

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