BRS Pérola: cultivar de soja indicada para o Maranhão, Piauí e Tocantins.

Cultivares de soja com elevado potencial produtivo são requeridas todos os anos pelos agricultores. A Embrapa Soja vem desenvolvendo cultivares de soja produtivas e adaptadas às diferentes regiões edafoclimáticas do Brasil. O objetivo deste trabalho é apresentar a cultivar BRS Pérola, desenvolvida pela Embrapa Soja em convênio com a Fapcen, indicada para o cultivo nos estados do Maranhão, norte do Tocantins e sudoeste do Piauí. A BRS Pérola é uma cultivar de soja convencional, do grupo de maturidade relativo 8.8, tipo de crescimento determinado, flor branca, pubescência marrom médio e cor de hilo marrom. Nas safras 2007/08, 2008/09, 2009/10 e 2010/11 ela foi avaliada em experimentos de Valor de Cultivo e Uso em diferentes locais no MA, PI, TO, decidindo-se então pelo seu lançamento. A cultivar apresenta elevado potencial produtivo, ficando acima das três cultivares testemunhas utilizadas nos experimentos (BRS Tracajá, M-Soy 8866 e P98C81), com rendimento médio de 3.652 kg/ha, ao passo que a média das testemunhas foi de 3.436 kg/ha, indicando ainda resistência às principais doenças da soja e estabilidade na altura de plantas, proporcionando a sua semeadura em áreas de baixas altitudes. A BRS Pérola é uma excelente opção de cultivar de soja convencional para o mercado

BRS 361: nova cultivar de soja convencional.

Trabalho publicado também nos Resumos do CONGRESSO BRASILEIRO DE SOJA, 6., 2012, Cuiabá

Cultivar de soja BRS 333RR: descrição, comportamento e indicação para o cultivo nos Estados do Maranhão, Piauí e Tocantins.

Autoria: MONTALVÁN, R. A. [i.e. MONTALVÁN DEL ÁGUILA, R.]

Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study

Background and aims: Familial hypercholesterolemia (FH) is an inherited disorder characterized by high levels of blood cholesterol from birth and premature coronary heart disease. Thus, the identification of FH patients is crucial to prevent or delay the onset of cardiovascular events, and the availability of a tool helping with the diagnosis in the setting of general medicine is essential to improve FH patient identification.Methods: This study evaluated the performance of the Dutch Lipid Clinic Network (DLCN) score in FH patients enrolled in the LIPIGEN study, an Italian integrated network aimed at improving the identification of patients with genetic dyslipidaemias, including FH.Results: The DLCN score was applied on a sample of 1377 adults (mean age 42.9 +/- 14.2 years) with genetic diagnosis of FH, resulting in 28.5% of the sample classified as probable FH and 37.9% as classified definite FH. Among these subjects, 43.4% had at least one missing data out of 8, and about 10.0% had 4 missing data or more. When analyzed based on the type of missing data, a higher percentage of subjects with at least 1 missing data in the clinical history or physical examination was classified as possible FH (DLCN score 3-5). We also found that using real or estimated pre-treatment LDL-C levels may significantly modify the DLCN score.Conclusions: Although the DLCN score is a useful tool for physicians in the diagnosis of FH, it may be limited by the complexity to retrieve all the essential information, suggesting a crucial role of the clinical judgement in the identification of FH subjects

Lipoprotein(a) Genotype Influences the Clinical Diagnosis of Familial Hypercholesterolemia

Background Evidence suggests that LPA risk genotypes are a possible contributor to the clinical diagnosis of familial hypercholesterolemia (FH). This study aimed at determining the prevalence of LPA risk variants in adult individuals with FH enrolled in the Italian LIPIGEN (Lipid Transport Disorders Italian Genetic Network) study, with (FH/M+) or without (FH/M-) a causative genetic variant. Methods and ResultsAn lp(a) [lipoprotein(a)] genetic score was calculated by summing the number risk-increasing alleles inherited at rs3798220 and rs10455872 variants. Overall, in the 4.6% of 1695 patients with clinically diagnosed FH, the phenotype was not explained by a monogenic or polygenic cause but by genotype associated with high lp(a) levels. Among 765 subjects with FH/M- and 930 subjects with FH/M+, 133 (17.4%) and 95 (10.2%) were characterized by 1 copy of either rs10455872 or rs3798220 or 2 copies of either rs10455872 or rs3798220 (lp(a) score >= 1). Subjects with FH/M- also had lower mean levels of pretreatment low-density lipoprotein cholesterol than individuals with FH/M+ (t test for difference in means between FH/M- and FH/M+ groups <0.0001); however, subjects with FH/M- and lp(a) score >= 1 had higher mean (SD) pretreatment low-density lipoprotein cholesterol levels (223.47 [50.40] mg/dL) compared with subjects with FH/M- and lp(a) score=0 (219.38 [54.54] mg/dL for), although not statistically significant. The adjustment of low-density lipoprotein cholesterol levels based on lp(a) concentration reduced from 68% to 42% the proportion of subjects with low-density lipoprotein cholesterol level >= 190 mg/dL (or from 68% to 50%, considering a more conservative formula). ConclusionsOur study supports the importance of measuring lp(a) to perform the diagnosis of FH appropriately and to exclude that the observed phenotype is driven by elevated levels of lp(a) before performing the genetic test for FH

Refinement of the diagnostic approach for the identification of children and adolescents affected by familial hypercholesterolemia: Evidence from the LIPIGEN study

Background and aims: We aimed to describe the limitations of familiar hypercholesterolemia (FH) diagnosis in childhood based on the presence of the typical features of FH, such as physical sings of cholesterol accumulation and personal or family history of premature cardiovascular disease or hypercholesterolemia, comparing their prevalence in the adult and paediatric FH population, and to illustrate how additional information can lead to a more effective diagnosis of FH at a younger age. Methods: From the Italian LIPIGEN cohort, we selected 1188 (≥18 years) and 708 (<18 years) genetically-confirmed heterozygous FH, with no missing personal FH features. The prevalence of personal and familial FH features was compared between the two groups. For a sub-group of the paediatric cohort (N = 374), data about premature coronary heart disease (CHD) in second-degree family members were also included in the evaluation. Results: The lower prevalence of typical FH features in children/adolescents vs adults was confirmed: the prevalence of tendon xanthoma was 2.1% vs 13.1%, and arcus cornealis was present in 1.6% vs 11.2% of the cohorts, respectively. No children presented clinical history of premature CHD or cerebral/peripheral vascular disease compared to 8.8% and 5.6% of adults, respectively. The prevalence of premature CHD in first-degree relatives was significantly higher in adults compared to children/adolescents (38.9% vs 19.7%). In the sub-cohort analysis, a premature CHD event in parents was reported in 63 out of 374 subjects (16.8%), but the percentage increased to 54.0% extending the evaluation also to second-degree relatives. Conclusions: In children, the typical FH features are clearly less informative than in adults. A more thorough data collection, adding information about second-degree relatives, could improve the diagnosis of FH at younger age

BRS 360RR: nova cultivar de soja.

A cultivar BRS 360RR foi desenvolvida pela Embrapa Soja em parceria com a Fundação Meridional de Apoio à Pesquisa Agropecuária e testada em Avaliação Final nas safras 2009/10 a 2010/11. Os ensaios foram instalados em blocos casualizados, com quatro repetições. Cada parcela foi constituída de quatro fileiras de 5,0 m de comprimento, espaçadas de 0,5 m, com área útil de 4,00 m2. A densidade de semeadura foi de 15 sementes aptas/metro linear. Esta cultivar é do tipo de crescimento indeterminado, pertence ao grupo de maturidade 6.2 ?precoce (ciclo de 104 a 129 dias) e possui pubescência cinza, flor branca e vagem cinza clara. Apresenta altura entre 102 e 122 cm e moderada resistência ao acamamento (entre 1,2 e 3,0). O tegumento da semente é de cor amarela, com brilho de intensidade baixa, o hilo é marrom claro, reação à peroxidase é positiva e o peso de 100 sementes é de 14,3 a 17,8 g (Tabela 1). Ela apresenta resistência a cancro da haste, podridão parda da haste, podridão radicular de fitóftora e mosaico comum da soja; possui moderada resistência a mancha ?olho-de-rã?, oídio e nematoide de galhas Meloidogyne incognita; apresenta ainda tolerância ao vírus da necrose da haste. Também, é tolerante ao herbicida glifosato. Os resultados obtidos com a BRS 360RR (Tabela 2) revelam sua ampla adaptação geográfica, sendo indicada para cultivo nas Regiões Edafoclimáticas REC 102 (meio-oeste de Santa Catarina e sudoeste do Paraná), REC 103 (centro-sul do Paraná e sul de São Paulo), REC 201 (oeste e norte do Paraná e médio Paranapanema em São Paulo), REC 202 (noroeste do Paraná, sudoeste de São Paulo e sul de Mato Grosso do Sul) e REC 204 (centro-sul e sudoeste de Mato Grosso do Sul). As regiões preferenciais para a produção de sementes desta cultivar são as RECs 102 e 103, de maior altitude, enquanto que, para a produção comercial de grãos, aadaptabilidade maior é nas RECs 201, 202 e 204, cuja altitude é menor que 600 m. Por apresentar bom porte em semeadura de início de outubro e em virtude da sua precocidade, esta cultivar apropria-se à sucessão do milho de segunda safra (safrinha), mantendo altos rendimentos em semeaduras até meados de novembro. A população indicada, em semeadura de 0,45 m entre sulcos, é de 12 a 14 sementes aptas por metro linear (270 a 310 mil plantas/ha) nas RECs 201 e 204 e de 14 a 16 sementes/m (310 a 350 mil plantas/ha) na REC 202 (arenito)