Pathways to Political Leadership for Women of Color Leaders

This research partnership was formed to better understand what motivates and sustains−as well as prevents−Asian American women, Latinas, and African American women from achieving greater rates of political leadership in Massachusetts. Five women of color leaders became research fellows and explored pressing issues such as family and cultural expectations, financial resources and fundraising, and the potential for compromised values. After two years of training, data collection, and analysis, online resources were developed and are now hosted on UMass Boston’s website

IPC02-27103 NATURAL HAZARD DATABASE APPLICATION -A TOOL FOR PIPELINE DECISION MAKERS

ABSTRACT Trans Mountain Pipe Line Company Ltd. (TMPL) owns and operates an 1146 km NPS 24 low vapor pressure petroleum products pipeline between Edmonton, Alberta and Burnaby, British Columbia. In 1998 TMPL retained BGC Engineering Inc. (BGC) to start a three-phase geotechnical and hydrotechnical hazard assessment of the right of way (ROW) from Hinton, Alberta to Kamloops, British Columbia. As part of this work GroundControl was asked to develop an electronic database with which to capture the information generated by BGC during the hazard assessment work. This paper describes the development and evolution of the database application that accompanied the study to quantitatively assess and prioritize the geotechnical and hydrotechnical hazard potential along the pipeline. This paper describes how the database provides TMPL employees across British Columbia and Alberta access to the current results of the hazard assessment plus supporting information such as multi-temporal images and internal and 3rd party reports about the pipeline. The purpose of the database and the unique architecture and functionality that accommodates ongoing monitoring and inspections of slopes and stream crossings is provided. Database security, access, and information sharing unique to TMPL are also described. Benefits and costs of the application plus technical and business challenges overcome by TMPL, BGC, and GroundControl are discussed. Recommendations from TMPL and GroundControl for similar information management initiatives are provided and future work is described. This paper is targeted to pipeline managers who are looking for economical, practical, and innovative information management solutions for managing their natural hazards. (Keywords: database, hazard, risk, pipeline, geotechnical, hydrotechnical, landslide, GIS, river, stream). NOMENCLATURE Database -A collection of data and objects related to a particular topic or purpose. A database can contain tables, queries, forms, and reports. Database Application -Custom programmed functionality built around a collection of database objects designed for a specific purpose. The hazard management tool described in this paper is a database application. Field -An element of a table that contains a specific item of information, such as last name. A column or cell in a table represents a field. Many fields often comprise a single row. On a form, a control, such as a text box, is used to display data from a field. Record -A collection of data about a hazard, an inspection, or some other item. A record is represented as a row in table, or query. Control -A graphical object, such as a text box, a check box, a command button, or a rectangle, that are placed on a form or report to display data, perform an action, or make the form or report easier to read. Form -A database object on which controls are placed for taking actions or for entering, displaying, and editing data in fields. Data in tables are often displayed with a form. Report -A database object that presents information formatted and organized according to user specifications. Examples of reports are summaries for a single hazard, a list of hazards, and reports that include photos and text. The results of query are often displayed in reports. Proceedings of IPC'02 Hazard -A description of the landslide or hydrotechnical event, including magnitude plus a quantitative or qualitative description of probability of occurrence. In this paper hazard is expressed as a numeric hazard score. Risk -The expected loss resulting from a hazard being triggered and impacting one or more elements. Risk is formally expressed in monetary terms. BACKGROUND In the last decade, Natural Hazard and Risk Management (NHRM) has become a widespread tool for multinational corporations. Proper risk management requires that the natural hazard be identified, assessed, and then managed in order to reduce its impact on public safety and the environment. However the management of natural hazards is not the sole responsibility of the engineering or environmental departments. The adoption of formalized risk management encourages an interdisciplinary approach to facility management that requires inputs from engineering, environmental, operational, legal, and financial departments. Database applications are often at the hub of this integrated approach as they provide shared access to data and tools necessary for the quantification of hazards and risk. Database applications are also there to help manage the diverse and detailed information that is collected over numerous cycles of hazard identification, monitoring, and mitigation. For the above reasons, TMPL required that a database application be constructed to conform to the four phase NHRM methodology developed by BGC. This paper describes that application

IPC2010-31419 BALANCING PIPELINE SAFETY AND COST INTEGRITY MANAGEMENT THROUGH PERFORMANCE VALIDATION OF IN-LINE INSPECTION DATA

ABSTRACT In-Line Inspection (ILI) surveys are widely employed to identify potential threats by capturing changes in pipe condition such as metal loss, caused by corrosion. The better the performance and interpretation of these survey data, the higher the reliability of being able to predict the actual condition of the pipe and required remediation. Each ILI survey has a certain level of conservatism from the assessment equations such as B31G and sensitivity to ILI performance for measurement uncertainty. Multiple levels of conservatism intended to limit the possibility of a non-conservative assessment can result in a significant economic penalty and excessive digs without improving safety. A study was undertaken to evaluate the reliability of responses to ILI corrosion features through multiple case studies examining the effects of failure criteria and data analysis parameters. This paper discusses the effect of validated ILI performance on safety, and addresses the risk of false acceptance of corrosion indications at a prescribed safety factor. The cost of unnecessary excavations due to falsely rejecting ILI predictions is also discussed

Antibody correlates of protection against Delta infection after vaccination: A nested case-control within the UK-based SIREN study

Objectives: To investigate serological correlates of protection against SARS-CoV-2 B.1.617.2 (Delta) infection after two vaccinations.// Methods: We performed a case-control study, where cases were Delta infections after the second vaccine dose and controls were vaccinated, never infected participants, matched by age, gender and region. Sera were tested for anti-SARS-CoV-2 Spike antibody levels (anti-S) and neutralising antibody titres (nAbT), using live virus microneutralisation against Ancestral, Delta and Omicron (BA.1, B.1.1.529). We modelled the decay of anti-S and nAbT for both groups, inferring levels at matched calendar times since the second vaccination. We assessed differences in inferred antibody titres between groups and used conditional logistic regression to explore the relationship between titres and odds of infection.// Results: In total, 130 sequence-confirmed Delta cases and 318 controls were included. Anti-S and Ancestral nAbT decayed similarly between groups, but faster in cases for Delta nAbT (p = 0.02) and Omicron nAbT (p = 0.002). At seven days before infection, controls had higher anti-S levels (p 40 were associated with reduced odds of Delta infection (89%, [69–96%]; p 100 (p = 0.009) and >400 (p = 0.007).// Conclusions: We have identified correlates of protection against SARS-CoV-2 Delta, with potential implications for vaccine deployment, development, and public health response

Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients.

Funder: Kidney Research U

CD4+ and CD8+ T cells and antibodies are associated with protection against Delta vaccine breakthrough infection: a nested case-control study within the PITCH study

Serological correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection after vaccination ("vaccine breakthrough") have been described. However, T cell correlates of protection against breakthrough are incompletely defined, especially the specific contributions of CD4+ and CD8+ T cells. Here, 279 volunteers in the Protective Immunity from T Cells in Healthcare Workers (PITCH) UK cohort study were enrolled in a nested case-control study. Cases were those who tested SARS-CoV-2 PCR or lateral flow device (LFD) positive after two vaccine doses during the Delta-predominant era (n = 32), while controls were those who did not report a positive test or undergo anti-nucleocapsid immunoglobulin G (IgG) seroconversion during this period (n = 247). Previous SARS-CoV-2 infection prior to vaccination was associated with reduced odds of vaccine breakthrough. Using samples from 28 d after the second vaccine dose, before all breakthroughs occurred, we observed future cases had lower ancestral spike (S)- and receptor binding domain-specific IgG titers and S1- and S2-specific T cell interferon gamma (IFNγ) responses compared with controls, although these differences did not persist when individuals were stratified according to previous infection status before vaccination. In a subset of matched infection-naïve cases and controls, vaccine breakthrough cases had lower CD4+ and CD8+ IFNγ and tumor necrosis factor (TNF) responses to Delta S peptides compared with controls. For CD8+ responses, this difference appeared to be driven by reduced responses to Delta compared with ancestral peptides among cases; this reduced response to Delta peptides was not observed in controls. Our findings support a protective role for T cells against Delta breakthrough infection. IMPORTANCE Defining correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine breakthrough infection informs vaccine policy for booster doses and future vaccine designs. Existing studies demonstrate humoral correlates of protection, but the role of T cells in protection is still unclear. In this study, we explore antibody and T cell immune responses associated with protection against Delta variant vaccine breakthrough infection in a well-characterized cohort of UK Healthcare Workers (HCWs). We demonstrate evidence to support a role for CD4+ and CD8+ T cells as well as antibodies against Delta vaccine breakthrough infection. In addition, our results suggest a potential role for cross-reactive T cells in vaccine breakthrough

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies characterizing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness