Międzynarodowy projekt dydaktyczny Wielojęzyczność regionu bałtyckiego w Instytucie Komunikacji Specjalistycznej i Interkulturowej Uniwersytetu Warszawskiego

The announcement presents the conception of the didactic project Multilingualism of the Baltic region, which has been carried out since the second half of 2022 in the Institute of Specialised and Intercultural Communication at the University of Warsaw thanks to funding granted by the university’s Teaching Excellence Fund. Special attention is given to the first part of the project focused on the language situation in Lithuania. This part of the project has been already completed. In October 2022, professors from Vilnius University, Lithuania taught a specialist course held in Russian language consisting of seven seminars and practical training. These types of projects respond to demand expressed by students interested in exploring languages and cultures of the Baltic region. They also pursue the goals of a contemporary university aiming for innovation in teaching.W komunikacie przedstawiono koncepcję projektu dydaktycznego Wielojęzyczność regionu bałtyckiego, który od drugiej połowy 2022 r. realizowany jest w Instytucie Komunikacji Specjalistycznej i Interkulturowej Uniwersytetu Warszawskiego dzięki środkom uniwersyteckiego Funduszu Doskonałości Dydaktycznej. Szczególną uwagę poświęcono zakończonej już pierwszej części projektu, dotyczącej sytuacji językowej na Litwie. W październiku 2022 r. wykładowcy z Uniwersytetu Wileńskiego przeprowadzili kurs specjalistyczny w języku rosyjskim, złożony z siedmiu zajęć zarówno teoretycznych, jak i praktycznych. Tego rodzaju projekty są odpowiedzią na aktualne potrzeby studentów, zainteresowanych poznawaniem języków i kultur krajów bałtyckich, a także na cele nowoczesnej uczelni dążącej do innowacyjności w dydaktyce. Tarptautinis didaktinis projektas „Daugiakalbystė Baltijos regione“ Varšuvos universiteto Specialiosios ir tarpkultūrinės komunikacijos institute Pristatoma didaktinio projekto „Daugiakalbystė Baltijos regione“, įgyvendinamo nuo 2022 m. antrojo pusmečio, koncepcija. Projektą vykdo Varšuvos universiteto Specialiosios ir tarpkultūrinės komunikacijos institutas, projekto rėmėjas – Varšuvos universiteto didaktikos tobulėjimo fondas. Ypatingas dėmesys skiriamas pirmajai projekto daliai, skirtai kultūrinės ir kalbinės situacijos raidai Lietuvoje apibūdinti. 2022 m. spalio mėn. Vilniaus universiteto dėstytojai parengė Varšuvos universiteto septynių seminarų ir pratybų specialų kursą rusų kalba. Tokio pobūdžio projektai atitinka studentų, norinčių susipažinti su Baltijos regiono kalbomis ir kultūromis, poreikį, taip pat modernaus universiteto, orientuoto į inovacijas mokymo srityje, tikslus. Reikšminiai žodžiai: didaktika, Lietuva, lietuvių kalba, rusų kalba, rusų diasporos kalba, daugiakalbystė

Paracetamol (acetaminophen) decreases hydrogen sulfide tissue concentration in brain but increases it in the heart, liver and kidney in mice

The biological action of N-acetyl-p-aminophenol - paracetamol (acetaminophen) has been demonstrated to involve different mechanisms and is still not clear. Hydrogen sulfide (H_{2}S) has been shown to play an important role in many physiological and pathological processes including nociception. The interaction between acetaminophen and endogenous H_{2}S is unknown. Twenty four female CBA strain mice were administered intraperitoneal injections of N-acetyl-p-aminophenol solution: paracetemol in doses of 30 mg/kg b.w. per day (group D1, n = 8) or 100 mg/kg b.w. per day (group D2, n = 8)‥ The control group (n = 8) received physiological saline in portions of the same volume–0.2 ml. The measurements of tissue H_{2}S concentration were performed with the Siegel spectrophotometric modified method. In the brain, the H_{2}S tissue level decreased, but more significantly in the lower drug dose group. Conversely, there was a significant rise in the H_{2}S tissue concentration in D1 and D2 groups in heart and kidney with the increase more pronounced in the group with the lower paracetamol dose. In the liver only the higher acetaminophen dose elicited a change in H_{2}S concentration, increasing after administration of acetaminophen at 100 mg/kg. Our study demonstrates that paracetamol induces H_{2}S tissue concentration changes in different mouse organs

Ramipril affects hydrogen sulfide generation in mouse liver and kidney

Hydrogen sulfide (H_{2}S) is a modulator of various physiological and pathological processes in the cardiovascular and nervous system and plays an important role in the regulation of gastrointestinal tract, liver and kidney function. The effect of the pleiotropic action of the tissue specific angiotensin-converting enzyme inhibitor (ACEI), ramipril, exceeds renin-angiotensin aldosterone system (RAAS) blockade and involves different biological mechanisms. The aim of the study is to assess the influence of ramipril on H_{2}S production in mouse liver and kidneys. Thirty mice (CBA) of both sexes were given intraperitoneal injections of ramipril solutions - 0.125 mg (5 mg/kg - group D1) and 0.25 mg (10 mg/kg - group D2) for 5 consecutive days at the same time of the day (10:30 am). The control group received physiological saline in portions of the same volume - 0.2 ml. The measurements of the tissue concentration of H_{2}S were performed using the modified spectrophotometric method of Siegel. There was a significant rise in the tissue concentration of H_{2}S [μg/g] in livers of group D1 (2.70 ± 0.02 vs 2.81 ± 0.06; P = 0.03) and group D2 (2.70 ± 0.02 vs 2.98 ± 0.03; P<0.001) and a significant decrease of H_{2}S kidney tissue concentration in group D1 (3.35 ±0.06 vs 3.15 ± 0.07; P = 0.02) and in group D2 (3.35 ± 0.06 vs 2.89 ± 0.03; P<0.001). Our results show that ACEI ramipril affects hydrogen sulfide generation in mouse liver and kidneys

Carvedilol induces endogenous hydrogen sulfide tissue concentration changes in various mouse organs

Carvedilol, a third generation non-selective adrenoreceptor blocker, is widely used in cardiology. Its action has been proven to reach beyond adrenergic antagonism and involves multiple biological mechanisms. The interaction between carvedilol and endogenous 'gasotransmitter' hydrogen sulfide (H_{2}S) is unknown. The aim of the study is to assess the influence of carvedilol on the H_{2}S tissue level in mouse brain, liver, heart and kidney. Twenty eight SJL strain female mice were administered intraperitoneal injections of 2.5 mg/kg b.w./d (group D1, n = 7), 5 mg/kg b.w./d (group D2, n = 7) or 10 mg/kg b.w./d of carvedilol (group D3, n = 7). The control group (n = 7) received physiological saline in portions of the same volume (0.2 ml). Measurements of the free tissue H_{2}S concentrations were performed according to the modified method of Siegel. A progressive decline in H_{2}S tissue concentration along with an increase in carvedilol dose was observed in the brain (12.5%, 13.7% and 19.6%, respectively). Only the highest carvedilol dose induced a change in H_{2}S tissue level in the heart - an increase by 75.5%. In the liver medium and high doses of carvedilol increased the H_{2}S level by 48.1% and 11.8%, respectively. In the kidney, group D2 showed a significant decrease of H_{2}S tissue level (22.5%), while in the D3 group the H_{2}S concentration increased by 12.9%. Our study has proven that carvedilol affects H_{2}S tissue concentration in different mouse organs

Non-interventional study evaluating the response to treatment in patients with chronic lymphocytic leukaemia (CLL) depending on rituximab-chemotherapy regimen

A multicenter, prospective, observational, non-interventional study evaluated the response to treatment in patients with chronic lymphocytic leukemia (CLL) depending on the rituximab-chemotherapy (R-chemo) regimen used in routine clinical practice in Poland. The primary endpoint was the overall response rate (ORR) regarding the R-chemo regimen. The secondary endpoints were complete remission (CR), partial remission (PR), progressive disease (PD) and stable disease (SD) rates. A total of 400 CLL patients were enrolled in 20 sites in Poland. Data were collected on-line using eCRF during 6-months rituximab treatment. There were 150 treatment-naive patients (37.5%) and 250 patients with recurrent disease (62.5%) enrolled to the study. The overall ORR in R-FC-treated patients was 87.28%, 78.57% for the R-COP regimen, and for other regimens – 51.72%. Complete remission was achieved in 141 patients (36.25%), including 16.40% in patients receiving first-line treatment and 11.76% in relapsed disease. Partial remission was achieved in 166 patients (42.67%), including 38.4% in patients on first-line treatment and 38.56% in patients treated for recurrence. Complete or partial responses were achieved in 78.92% in total. No new safety signals were detected in comparison to safety profile described in Summary of Product Characteristics

Female Fabry disease patients and X-chromosome inactivation

Fabry disease is an X-linked inherited lysosomal storage disorder caused by mutations in the gene encoding α- galactosidase A (GLA). Once it was thought to affect only hemizygous males. Over the last fifteen years, research has shown that most females carrying mutated allele also develop symptoms, demonstrating a wide range of disease severity, from a virtually asymptomatic to more classical profile, with cardiac, renal, and cerebrovascular manifestations. This variable expression in females is thought to be influenced by the process of X-chromosome inactivation (XCI). The aim of this study was to assess severity of the clinical phenotype, to analyze XCI patterns, and to estimate their effect on disease manifestation in twelve female Fabry disease patients from five unrelated Polish families. Our analyses revealed that patients presented with the broad range of disease expression - from mild to severe, and their clinical involvement did not correlate with XCI profiles. Female carriers of the mutation in the GLA gene with the random XCI may present with the wide range of disease signs and symptoms. Thus, XCI is not a main factor in the phenotype variability of Fabry disease manifestation in heterozygous females

Improving electrical and thermal surface properties of polymer composite materials

Treballs Finals de Grau d'Enginyeria Química, Facultat de Química, Universitat de Barcelona, Curs: 2016-2017, Tutores: Núria Llorca Isern, Ana Maria Escobar RomeroThe use of new composite materials has increase in the last decades due to the possibility to achieve great properties with the combination of two or more materials. A great example is carbon fibre reinforce polymers (CFRPs), which are intensively use in many applications for their good strength to weight ratio. These materials are apparently an ideal component for aircraft industrial; however, the electrical and thermal conductivity they exhibit makes it unsuitable for certain applications like lightening strike protection. To achieve better performance on CFRPs, it is common to metallise the surface with aluminium, copper or others conductive materials. In this project two different approaches have been compared: joining, with adhesive tape, and coating, with electrochemical deposition and sputtering. The electrical conductivity of the samples, before and after the metallization, has been studied with the 4-probes method and we have studied the influence of thickness on thermal and electrical conductivity

Dzieci sieci 2.0

S\u142owa kluczowe: kompetencje komunikacyjne m\u142odzie\u17cy, edukacja medialna - gimnazjum, szkolne programy nauczania, netnografia, internet a uczniowie gimnazj\uf3

Variant O89 O-Antigen of E. coli Is Associated With Group 1 Capsule Loci and Multidrug Resistance

<p>Bacterial surface polysaccharides play significant roles in fitness and virulence. In Gram-negative bacteria such as Escherichia coli, major surface polysaccharides are lipopolysaccharide (LPS) and capsule, representing O- and K-antigens, respectively. There are multiple combinations of O:K types, many of which are well-characterized and can be related to ecotype or pathotype. In this investigation, we have identified a novel O:K permutation resulting through a process of major genome reorganization in a clade of E. coli. A multidrug-resistant, extended-spectrum β-lactamase (ESBL)-producing strain – E. coli 26561 – represented a prototype of strains combining a locus variant of O89 and group 1 capsular polysaccharide. Specifically, the variant O89 locus in this strain was truncated at gnd, flanked by insertion sequences and located between nfsB and ybdK and we apply the term O89m for this variant. The prototype lacked colanic acid and O-antigen loci between yegH and hisI with this tandem polysaccharide locus being replaced with a group 1 capsule (G1C) which, rather than being a recognized E. coli capsule type, this locus matched to Klebsiella K10 capsule type. A genomic survey identified more than 200 E. coli strains which possessed the O89m locus variant with one of a variety of G1C types. Isolates from our collection with the combination of O89m and G1C all displayed a mucoid phenotype and E. coli 26561 was unusual in exhibiting a mucoviscous phenotype more recognized as a characteristic among Klebsiella strains. Despite the locus truncation and novel location, all O89m:G1C strains examined showed a ladder pattern typifying smooth LPS and also showed high molecular weight, alcian blue-staining polysaccharide in cellular and/or extra-cellular fractions. Expression of both O-antigen and capsule biosynthesis loci were confirmed in prototype strain 26561 through quantitative proteome analysis. Further in silico exploration of more than 200 E. coli strains possessing the O89m:G1C combination identified a very high prevalence of multidrug resistance (MDR) – 85% possessed resistance to three or more antibiotic classes and a high proportion (58%) of these carried ESBL and/or carbapenemase. The increasing isolation of O89m:G1C isolates from extra-intestinal infection sites suggests that these represents an emergent clade of invasive, MDR E. coli.</p