Angiotensin II Type 1 Receptor (AT-1R) Expression Correlates with VEGF-A and VEGF-D Expression in Invasive Ductal Breast Cancer

Recent studies point to the involvement of angiotensin II (Ang II) receptor type 1 (AT-1R) on processes of metastasing, stimulation of invasiveness and angiogenesis in tumours. In this study, the correlation between intensity of AT-1R expression and expression of lymph- and angiogenesis markers in invasive ductal breast cancers (IDC) was examined. Immunohistochemical studies (IHC) were performed on archival material of 102 IDC cases. Only 28 (27.5%) cases manifested low AT-1R expression while 74 (72.5%) cases demonstrated a moderate or pronounced AT-1R expression. Expression intensity of AT-1R was found to correlate with expressions of VEGF-A (r = 0.26; p = 0.008) and VEGF-D (r = 0.24; p = 0.015). Out of the examined markers of angiogenesis and lymphangiogenesis only the pronounced expression of VEGF-C was found to correlate with patient poor clinical outcome (p = 0.009). The positive correlation between AT-1R and VEGF-A and VEGF-D could point to stimulatory action of Ang II on their expression what might result in augmented lymph- and angiogenesis in IDC

Polycystic ovary syndrome (PCOS) - risk factor, diagnostic and current treatment

Introduction:  Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders in women in reproductive age, defined as a combination of signs and symptoms resulting from androgen excess and ovarian dysfunction in the absence of other specific diagnoses. PCOS is often associated with an increased risk of obesity, insulin resistance, metabolic disorders and cardiovascular events. The aim of the study: The purpose of this systemic review was to collect and analyze materials about risk factors, diagnostics, and the current treatment of polycystic ovary syndrome.Material and method: Review of the literature published in 2004-2018.Description of the state of knowledge: PCOS is characterized by an excessive secretion of androgens from the ovaries and / or adrenal glands. Intrinsic ovarian factors, such as altered steroidogenesis, and factors external to the ovary, such as hyperinsulinemia, contribute to the ovarian overproduction of androgens. PCOS requires careful selection of an appropriate diagnostic method and therapeutic approach to combat hyperandrogenism, a consequence of ovarian dysfunction and related metabolic disorders. Treatment of both women at risk of PCOS and those with a confirmed diagnosis of PCOS includes education, healthy lifestyle interventions and symptomatic therapeutic interventions.Summary:  PCOS is a complex disorder involving many organs and affecting many body functions. It is important to diagnose this disease as soon as possible in order to implement appropriately selected therapeutic treatment aimed at eliminating disease symptoms and reducing the systemic consequences of hyperandrogenism in patients

Central retinal vein occlusion in hypertensive patient — a case report

Retinal vein occlusion (RVO) is, beside diabetic retinopathy, the most common retinal vascular disease. RVO is associatedwith many risk factors, both systemic and ocular. Among the systemic risk factors is hypertension. A 36-year-old man came to the hospital because of impaired vision. Central retinal vein occlusion (CRVO) was diagnosed. The main reason for developing RVO was the untreated hypertension, which was diagnosed in the form of hypertensive crisis. The patient presented numerous additional CRVO risk factors that contributed to the development of the described pathology like: obesity, dyslipidaemia, hyperhomocysteinaemia, renal cancer. The authors suggested active examination for CRVO risk factors regardless of the age of patients

Archeologizacja krajobrazu. Dynamika współczesnych przemian i negocjowanie społecznych znaczeń - przykład wybranych wsi Jury Krakowsko-Częstochowskiej

In the article, the authors describe the process of archaeologization of selected objects in the local landscape, using examples from five municipalities located in the northern areas of the Polish Jurassic Highland. They look at the processes of persistence or transformation (replacement, revitalization, expansion) and abandonment (destruction, disappearance). The analysis of the collected materials combines the perspectives of archaeology and ethnography/cultural anthropology. It is part of the understanding of landscape as a cultural heritage that runs over time, its form and meaning are fields for negotiation by various entities (local communities, state administration and experts/researchers).In the article, the authors describe the process of archaeologization of selected objects in the local landscape, using examples from five municipalities located in the northern areas of the Polish Jurassic Highland. They look at the processes of persistence or transformation (replacement, revitalization, expansion) and abandonment (destruction, disappearance). The analysis of the collected materials combines the perspectives of archaeology and ethnography/cultural anthropology. It is part of the understanding of landscape as a cultural heritage that runs over time, its form and meaning are fields for negotiation by various entities (local communities, state administration and experts/researchers)

Folic acid supplementation among students

Introduction: Pregnancy is a period in which the supply of vitamins, micro- and macroelements is essential for the proper growth of the fetus. One of the most important substances, which is believed to have a considerable influence on the proper fetus growth is folic acid. Folic acid (i.e. vitamin B9) plays a significant role in rapidly dividing cells and lack of this vitamin causes serious fetal defects - for example neural tube anomalies. Supplementation is important not only during pregnancy but also during the period of pregnancy planning. Methods: Students' knowledge regarding the importance of folic acid supplementation was verified using anonymous Internet questionnaire. The obtained results were analyzed using statistical methods and checked on the basis of scientific literature. Results: The percentage of students who supply folic acid is 18,1% and only 9,5% do this regularly. The most common cause of supply is due to the fact that that folate can be found in vitamin kits students usually take. Part of respondents claim that they plan the pregnancy and want the fetus to develop correctly. Other causes of vitamin B9 intake is prevention of arteriosclerosis, vascular system diseases, anemia, lung, esophagus and uterus cancer. Conclusion: Outcomes showed that students are not fully aware of the importance of vitamin B9 during pregnancy and there is a great need to share knowledge about folic acid supplementation among people in procreative age

Restoring the patency of fallopian tubes using the transcervical selective hysterosalpingography methods - a clinical case analysis

Abstract Introduction: Infertility caused by tubal occlusion is a relatively frequent affliction among women of child-bearing age. A common cause of tubal occlusion are mucous plugs accumulated inside the fallopian tubes, which results in blocking them. Selective hysterosalpingography (SHSG) is a method of removing the obstruction located in a proximal section of the fallopian tube. The most serious complication developed from this procedure is a fallopian tube perforation, however, it affects less than 1% of patients who undergo the treatment. The clinical success of recanalization of the fallopian tubes is estimated at about 85-88% and the frequency of successful pregnancies after the treatment is about 27%. Aim: To show the usage and effectiveness of SHSG in diagnosis and treatment in the obstruction of proximal section of fallopian tube. Case report: The patient, 33 years old, diagnosed with primary infertility, qualified to the SHSG at Independent Public Clinical Hospital No. 4 in Lublin. The first stage of SHSG was the insertion of a catheter into the uterine cavity and introduction of a contrast agent to the uterine cavity. The fallopian tubes did not release the contrast into the peritoneal cavity. After increasing the contrast, delivery pressure agent obtained the free flow of the contrast agent into the peritoneal cavity through the right fallopian tube. The uterine outlet of the left fallopian tube was selectively catheterized and a micro tool was inserted into the left fallopian tube. As the result, both fallopian tubes were unblocked. Summary: SHSG is a non-invasive and safe method of removing the obstruction located in the proximal section of the fallopian tube. Women subjected to SHSG can return to their normal activities in a few hours after treatment

Migraine headaches as a complication of the atrial fibrillation ablation procedure: case report

The balloon cryoablation (CA) procedure is an established method for the permanent treatment of atrial fibrillation (AF). Like other surgical interventions, it is associated with the potential development of early and late complications, including neurological ones such as migraine. We report a case of migraine headaches after the CA procedure. 25-year-old man with paroxysmal AF, without comorbidities, underwent balloon CA. On the second day after the procedure, the patient developed visual symptoms typical of migraine aura. After 30 minutes, these symptoms disappeared and appeared classic migraine headache attack. Similar episodes occurred over the following days. A focal central nervous system lesion was ruled out and a diagnosis of migraine with aura was made. The patient received a typical migraine attack treatment. The attacks ceased within two weeks. 3 months later during the follow-up visit at the neurology clinic no abnormalities were detected. We decided to check if the migraine is a rare complication of AF ablation surgery. Many studies do not include migraine headaches at all in the neurological complications of ablation. However, based on some studies, it may seem that the incidence of migraine as a complication of ablation is underestimated