Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Emotional Intelligence: perspectives and reflections before the era of the new normality

The research analyzes emotional intelligence in the era of the new normal. From the dialogic hermeneutics, conception of classical and current disciplinary theoretical referents, giving rise to perspectives and reflections. It is concluded that the strategies for emotional regulation, social awareness and facilitating emotions are articulated to integrate emotional intelligence, impacted by economic, social, environmental and political factors, insisting on the reinvention of the living being, modifying structures, models and management of people in business, allowing selfrecognition of the human being and the assessment of their behavior, highlighting their sensitivity and control.En la investigación se analiza la inteligencia emocional ante la era de la nueva normalidad. A partir de la hermenéutica dialógica, concepción de referentes teóricos clásicos y actuales disciplinares, dando origen a las perspectivas y reflexiones. Se concluye que las estrategias de regulación emocional, conciencia social y facilitar las emociones, se articulan para integrar la inteligencia emocional, impactada por factores económicos, sociales, ambientales y políticos, incidiendo en la reinvención del ser vivo, modificando estructuras, modelos y la gestión de personas en los negocios, permitiendo el autoreconocimiento del ser humano y la valoración de su comportamiento, destacando su sensibilidad y control