Anti-inflammatory choline based ionic liquids: Insights into their lipophilicity, solubility and toxicity parametrites

The impact on in vivo efficacy and safety of two novel ionic liquids based on the association of choline with nonsteroidal anti-inflammatory drugs, ketoprofen and naproxen forming IL-APIs, was evaluated. Their lipophilicity, solubility and toxicity were assessed aiming the illustration of the pharmaceutical profile and potential toxic impact. Partition coefficientwas determined usingmicelles of hexadecylphosphocholine and UV–Vis derivative spectroscopy. Additionally, solubility in phosphate buffer pH 7.4 wasmeasured using amodified shake flaskmethod and UV–Vis spectroscopy as detection technique. Ultimately, toxicity was considered resorting to a fully automated cytochrome c oxidase assay based onmicrofluidics. The obtained results demonstrated that the IL-APIs' drug format has the ability to interact with biological membranes and also improves solubility up to 58 times. Moreover, it was evidenced that, although being a nutrient, choline influences the IL-APIs' toxicity. The studied anti-inflammatory IL-APIs exhibited promising properties regarding their incorporation in pharmaceutical formulations

Profile Of Users In An Emergency Care [perfil De Usuários Em Um Serviço De Pronto Atendimento]

The objective of this study was to identify the profile of users treated in emergency care of a district of Ribeirao Preto - SP. Quantitative Study users seeking the emergency care between January to June 2009. Were characterized by sex, age, time, day of week and months of peak demand, demand justification, conduct and referrals. Of the 45,771 visits made, was selected a sample of 330 medical records by random sampling technique. Of these, 57% of users were female and 63.3% are users between 20 and 50 years. The months of greatest demand were in March, April and May and 70.7% of cases occurred during the day. In 20% of justifications were reports of pain. In 77,2% of the ducts are drug therapy and 26.3% test ordering. Among the many justifications for the search by the emergency care are the potential of this service in the form of high-density technology.4513138(2009) Garantindo Saúde Nos Municípios, , Brasil. Ministério da Saúde. O SUS de A a Z. Brasília, MS, 3 o.edPinto, I.C., Rodolpho, F., Oliveira, M.M., Pronto-atendimento: A percepção da equipe de Enfermagem quanto ao seu trabalho no setor de recepção (2004) Rev Gaúch Enferm, 25, pp. 81-88(1988), http://www.cremesp.org.br/clippings/legislacao_anteriores_integra.php, Conselho Regional de Medicina. Disponível em: Acesso em: 09/05/2006Levin, J., (1987) Estatística Aplicada A Ciências Humanas, , 2 oed. São Paulo: HarbraTriola, M.F., (1999) Introdução A Estatística, , 7 o ed. Rio de Janeiro: LTCRamos, D.D., Lima, M.A.D.S., Health care access and receptivity to users in a unit in Porto Alegre, Rio Grande do Sul, Brazil (2003) Cad Saúde Pública, 19, pp. 27-34Marco conceptual del acceso a los servicios de salud Determinantes del Acceso A Los Servicios de Salud en El Peru. [Online], , http://www.inei.gob.pe/biblioineipub/bancopub/est/lib0387/indice.htm, Disponível emGaioso, V.P., Mishima, S.M., User satisfaction from the perspective of acceptability in the family health scenario (2007) Texto Contexto - Enferm, 16, pp. 617-625Faef, S., Pain: The fifth vital sign (2002) Rev Latinoam Enferm, 10, pp. 446-447Kovacs, M.H., Feliciano, K.V.O., Sarinho, S.W., Aaca, V., Access to basic care for children seen at emergency departments (2005) J. Pediatr., 81, pp. 251-258Batistela, S., Guerreiro, N.P., Rossetto, N.G., Os motivos de procura pelo Pronto Socorro Pediátrico de um hospital Universitário referidos pelos pais ou responsáveis (2008) Semina: Ciências Biológicas e Da Saúde, 29, pp. 121-130Tanaka, O.Y., Resenburg, C.P., Analysis of the use of an ambulatory unit of the Department of Health of the city of São Paulo, Brazil (1990) Rev. Saúde Pública, 24, pp. 60-68Souza, M.F., Pinto, I.C., Figueiredo, L.A., Análise da utilização do serviço de pronto-socorro na percepção do usuário (2010) Ciênc Cuid Saúde, 9, pp. 13-20Puccini, P.T., Cornetta, V.K., Caseload profile in emergency services: Sentinel events for monitoring primary health care (2008) Cad Saúde Pública. [Online], 24 (9), pp. 2032-204

Detection of cheese whey and caseinomacropeptide in fermented milk beverages using high performance liquid chromatography

Cheese whey level and caseinomacropeptide (CMP) index of fermented milk beverages added with four levels of cheese whey (0, 10, 20, and 40%) and stored at 8-10oC for 0, 7, 14 and 21 days were determined by high performance liquid chromatography-gel filtration (HPLC-GF). Additionally, the interference of the starter culture and the storage time on the detection of cheese whey and CMP were investigated. Refrigerated storage up to 21 days did not affect (P>0.05) cheese whey and CMP amounts in milk (0% of cheese whey) and in fermented milk beverages added with 10 and 20% of cheese whey (P>0.05). However, cheese whey and CMP amounts were higher than expected (P<0.05) in fermented milk beverages added with 40% of cheese whey and stored for 21 days