Co-amorphization of olanzapine for solubility enhancement

Communication presented at the 3rd International Congress of CiiEM - Research and Innovation in Human and Health Sciences. Monte da Caparica, Portugal, 20-22 June 2018N/

BIM Approach in Construction Safety-A Case Study on Preventing Falls from Height

The construction industry has one of the highest occupational accident incidence rates among all economic sectors. Currently, building information modelling (BIM) appears to be a valuable tool for analysing occupational safety issues throughout the construction life cycle of projects, helping to avoid hazards and risks and, consequently, increasing safety. This work investigates BIM methodology and the application of related technologies for building safety planning and demonstrates the potential of this technology for the integrated implementation of safety measures during the design phase and construction site management. The first step consisted of a literature review on applying BIM-related technologies for safety in the design and planning phases. Following this, to show the potentialities of construction simulation, a case study based on BIM 4D to prevent falls from height was developed. With BIM 4D, it is possible to follow the construction process over time, giving the construction safety technicians, designers, supervisors and managers the capability to analyse, in each phase, the potential risks and identify which safety measures should be implemented. BIM can effectively integrate safety measures from the design phase to the construction and use phase and enable integrated safety planning within construction planning, leading to reliable safety management throughout the construction process

Evaluation of the ability of powdered milk to produce mini-tablets to deliver paracetamol in pediatrics

Paper presented at the 7th International Granulation Workshop. 1-3 July 2015, University of Sheffield, UK"This work aims to evaluate the usefulness of powdered milk as a vehicle of drugs for direct compression into mini-tablets specifically designed for the pediatric population. A 23 full factorial design was carried out to identify the effect of selected variables and their interactions (paracetamol to milk ratio, fraction of disintegrant and compression force), on selected responses (weight variation, thickness and tensile strength of minitablets and dissolution time of paracetamol) of the mini-tablets. Tablets were manufactured according to a matrix design resulting in eight combinations of four different tableting formulations compacted at two distinct forces. Each batch of tablets was evaluated for thickness (n=6), uniformity of weight (n=20), diametric crushing strength and tensile strength (σ) (n=6) and dissolution testing (n=12). A stepwise multiple linear regression was used to identify and quantify the relationships between each response and the variables studied and their interactions. Results were analyzed by ANOVA to identify the significant variables and variable interactions responsible for the effects observed.The increase on milk fraction in the formulation improved the compressibility of paracetamol with a decrease on weight variation. Thinner and harder compacts with slower paracetamol releases were also obtained. These observations were not surprising if powdered milk composition is taken into consideration: milk proteins, lactose (widely used as diluent) and lipids (often used as binders, lubricants and taste masking agents), which individually or in combination contribute to easier the production of tablets. A marked decrease on the dissolution time was observed as sodium croscarmellose was added to the milk rich formulations, as anticipated. The increase of the compression force was reflected by the production of thinner compacts with slightly higher tensile strengths but little effect on the dissolution median time. At high forces it was often observed a higher crushing strength and an increase of the importance of particle deformation in disintegration time.The study has proved the viability of using powdered milk on the production of minitablets to the delivery of drugs. The experimental design and statistical analysis enabled the identification of the most significant variables and their interactions affecting the properties of the mini-tablets, particularly the milk/paracetamol ratio which proved to be critical for the proprieties of the final product."Fundação para a Ciência e Tecnologia (FCT

Effect of different excipients and processing conditions on casein micellar formulation for children

Poster presented at the AAPS Annual Meeting and Exposition (American Association of Pharmaceutical Scientists). October 25-29, 2015, Orlando (FL), USA"Purpose: Investigation of the potential of casein micellar formulations as drug vehicles in pediatrics."Fundação para a Ciência e a Tecnologia (PTDC/DTP-FTO/1057/2012

Downstream processing of co-amorphous olanzapine

Abstract of poster presented at the 12th PBP World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Wien, Austria, 11-14 May 2021 (virtual meeting)N/

Evaluation of the ability of powdered milk to produce minitablets containing paracetamol for the paediatric population

The work aims at evaluating the usefulness of powdered milk as a drug matrix for the production of minitablets specifically designed for children. Mixtures made of powdered milk, paracetamol, mannitol, sodium croscarmellose and magnesium stearate (evaluated for flow properties, cohesiveness and caking tendency) were compacted into beams (evaluated for deformation, elasticity and stiffness) and minitablets (evaluated for uniformity of mass, thickness, tensile strength and paracetamol mean dissolution time) and a 23 factorial design performed. The increase on milk fraction in the formulation improved the compressibility of paracetamol and hardness of compacts, reducing weight variation and paracetamol release. A marked decrease on the dissolution time was observed as sodium croscarmellose was added to the milk rich formulations. The increase of the compression force resulted in the production of thinner compacts but had little effect on dissolution time. The production of beams has shown that deformation, bending strength and stiffness increased with both milk and compaction pressure, and decreased with sodium croscarmellose, whereas elasticity decreased when all variables increased. Tensile strength and mean dissolution time described minitablets well, unlike compaction force. The study has proved that powdered milk is suitable for the production of minitablets by direct compression of poor compressible drugs.info:eu-repo/semantics/publishedVersio

Addressing drug solubility problems : a case-study

Poster presented at the 10th iMed.ULisboa Postgraduate Students Meeting & 3rd i3DU Meeting. 24-25 Julho 2018, LisboaN/

Assessment of the stability of co-amorphous Olanzapine in tablets

Abstract of the poster presented at the 4th International Congress of CiiEM - "Health, Well-being and Ageing in the XXI Century." 2-5 June 2019, Monte de Caparica, PortugalN/

Drug-excipient and drug-drug mixtures : a pathway for the production of co-amorphous entities

Abstract of the communication presented at the 3rd International Congress of CiiEM ‘Research and Innovation in Human and Health Sciences’. Campus Egas Moniz, Caparica, Portugal, June 20-22, 2018N/