Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice

Fortilin, a pro-survival molecule, inhibits p53-induced apoptosis by binding to the sequence-specific DNA-binding domain of the tumor suppressor protein and preventing it from transcriptionally activating Bax. Intriguingly, fortilin protects cells against ROS-induced cell death, independent of p53. The signaling pathway through which fortilin protects cells against ROS-induced cell death, however, is unknown. Here we report that fortilin physically interacts with the antioxidant enzyme peroxiredoxin-1 (PRX1), protects it from proteasome-mediated degradation, and keeps it enzymatically active by blocking its deactivating phosphorylation by Mst1, a serine/threonine kinase. At the whole animal level, the liver-specific overexpression of fortilin reduced PRX1 phosphorylation in the liver, enhanced PRX1 activity, and protected the transgenic animals against alcohol-induced, ROS-mediated, liver damage. These data suggest the presence of a novel oxidative-stress-handling pathway where the anti-p53 molecule fortilin augments the peroxidase PRX1 by protecting it against degradation and inactivation of the enzyme. Fortilin-PRX1 interaction in the liver could be clinically exploited further to prevent acute alcohol-induced liver damage in humans

What Makes a Better Smeller?

Olfaction is often viewed as difficult, yet the empirical evidence suggests a different picture. A closer look shows people around the world differ in their ability to detect, discriminate, and name odors. This gives rise to the question of what influences our ability to smell. Instead of focusing on olfactory deficiencies, this review presents a positive perspective by focusing on factors that make someone a better smeller. We consider three driving forces in improving olfactory ability: one's biological makeup, one's experience, and the environment. For each factor, we consider aspects proposed to improve odor perception and critically examine the evidence; as well as introducing lesser discussed areas. In terms of biology, there are cases of neurodiversity, such as olfactory synesthesia, that serve to enhance olfactory ability. Our lifetime experience, be it typical development or unique training experience, can also modify the trajectory of olfaction. Finally, our odor environment, in terms of ambient odor or culinary traditions, can influence odor perception too. Rather than highlighting the weaknesses of olfaction, we emphasize routes to harnessing our olfactory potential

Who shapes the politics of expertise? Co-production and authoritative knowledge in Thailand’s political forests

Expert environmental knowledge has often been described as a governmental rationality that reduces political debate and facilitates state control. In this paper, I argue instead that this line of reasoning simplifies how knowledge gains political authority, especially when expertise is shared and left unchallenged by diverse actors, including those in conflict with each other. Using the framework of co-production from Science and Technology Studies (STS), I apply this argument to conflicts over the supposed watershed functions of forests in Thailand, where simplified narratives about the impacts of land use on water supply are used as justifications for territorialisation and restrictions on forest land. In particular, I focus on local resistance to the proposed Kaeng Sua Ten dam in northern Thailand in order to demonstrate how protestors have deliberately reproduced formal expertise to empower themselves, but by so doing also reinforcing simplified visions of watershed science and community culture. I argue that exposing the co-production of authoritative knowledge and visions of social order offer greater opportunities for understanding the role of expertise as a political force than analysing competing assemblages based on oppositions of state-led expert knowledge and traditional local practices