Improving Medication Adherence In Hypertensive Patients: A Scoping Review

Nos últimos anos, o interesse na área da adesão terapêutica tem aumentado de forma significativa. O panorama da adesão tem sido estudado particularmente na área do tratamento da hipertensão arterial; de facto, já foram desenvolvidas numerosas intervenções na tentativa de melhorar a adesão terapêutica em doentes hipertensos. No entanto, este tem sido um esforço frequentemente frustrante e desorganizado. O objetivo do presente estudo foi a realização de uma scoping review de intervenções destinadas a melhorar a adesão terapêutica em doentes hipertensos, de forma a fornecer uma visão mais clara e estruturada desta área. Além disso, desenvolveu-se um novo sistema de categorização de intervenções, baseado em evidência. A presente revisão foi realizada de acordo com o PRISMA-ScR statement. As bases de dados utilizadas foram a MEDLINE e a Web of Science, sendo que se incluíram estudos desde a criação das bases de dados até o dia 17 de agosto de 2020. De um número inicial de 2994 estudos não duplicados, 45 artigos foram incluídos após a realização das fases de screening e elegibility. Estes artigos foram analisados de acordo com o seu desenho, características dos participantes e estratégias de gestão de adesão aplicadas. De igual forma, avaliaram-se os seus outcomes relativos a indicadores de adesão terapêutica e pressão arterial, bem como os métodos utilizados para medir adesão. Posteriormente, cada intervenção descrita foi categorizada de acordo com um novo sistema de categorização, baseado em evidência e desenhado de acordo com o framework de conceptual clustering, amplamente utilizado em machine learning. Ao apresentar uma visão geral e organizada desta área de investigação, criando ainda uma nova ferramenta de categorização de intervenções, este trabalho revela-se um marco importante no desenvolvimento informado e eficiente de futuras intervenções em adesão terapêutica. Adicionalmente, para profissionais de saúde esta é uma fonte de informação valiosa sobre adesão terapêutica em doentes hipertensos.In recent years, interest in medication adherence has greatly increased. Adherence has been particularly well studied in the context of arterial hypertension treatment. Numerous interventions have addressed this issue, however, the effort to improve adherence has been often frustrating and frequently disorganized. The aim of present study was to perform a scoping review of medication adherence interventions in hypertensive patients, so that a clear overview was achieved. Moreover, an evidence-based categorization of interventions was developed. The review was performed according to the PRISMA-ScR statement. MEDLINE and Web of Science were searched, and studies published from database inception until August 17, 2020 were included. A total of 2994 non-duplicate studies were retrieved. After screening and eligibility phases, a total of 45 articles were included. Studies were analyzed regarding their design, participant characteristics and management of adherence strategies employed. Furthermore, medication adherence and blood pressure outcomes, as well as adherence measuring tools were evaluated. Each study's intervention was then categorized using a novel evidence-based system of categorization, derived from the conceptual clustering framework used in machine learning. This work is an important step in pushing for better informed and more efficient future research efforts, both by providing an overview of the research field and by creating a new, evidence-based intervention categorization tool. It also provides valuable information to clinicians about medication adherence to antihypertensive therapy

20th International Symposium on Solubility Phenomena and Related Equilibrium Processes: book of abstracts

TheWelcome to the 20th edition of the International Symposium on Solubility Phenomena and Related Equilibrium Processes held at the Polytechnic Institute of Bragança, in Portugal, from 4 to 9 of September, 2022, including the meeting of IUPAC Subcommittee on Solubility and Equilibrium Data (SSED). This biennial IUPAC symposium once again gathers international experts on solubility studies, or related subjects, to exchange scientific research and technological applications within the academic, scientific, and technical communities. From ancient Greece, the concept of a symposium encompasses the discussion in a vivid, enlightening, and convivial way. The current impediments to set up an in-person meeting did not limit this spirit or its objectives. The symposium aims to celebrate creativity, diversity, and friendship among participants, promoting the exchange of ideas and fruitful interactions. For that purpose, we have about 110 delegates from 25 countries, and your active participation is highly acknowledged. The general importance of solubility phenomena and associated physical properties is addressed in a variety of settings ranging from green chemistry to nuclear waste disposal, always envisaging applications for a sustainable development. This edition includes the contribution of 7 invited lectures and 48 oral presentations distributed in eleven sessions, and 34 posters that will be presented in two dedicated sessions. The abstracts cover a broad range of topics in search for innovative solutions in a sustainable development framework (e.g., greenhouse gases solubility, deep eutectic solvents and ionic liquids applications, remediation of mining and industrial impacts, mineral recovery from brines and seawater and energy storage, among others). Two additional workshop sessions organized within the activities of the project “Workshop on Assessment of Reliability and Uncertainty of Solubility Data” will be open to the participants on Wednesday afternoon, aiming to give fundamental and practical knowledge on good practices for phase equilibria measurements, data analysis, and reporting high quality data to the scientific community. The Franzosini award will be announced in a special session on Friday, in recognition of a promising young contributor to this area. On that same day, the best poster and oral presentation by young scientists will be also awarded. Finally, we would like to express again our deepest appreciation to all the participants, but also to the members of the Organizing Committee and International Advisory Board for their contribution to the conference and acknowledge the institutional support of IUPAC, SSED, Instituto Politécnico de Bragança, Centro de Investigação de Montanha, Sociedade Portuguesa de Química, Springer, and the reference SCI publications Journal of Solution Chemistry and Pure and Applied Chemistry.info:eu-repo/semantics/publishedVersio

Solubility of salts in mixed solvents: experimental data and modeling

Phase equilibria in electrolyte systems has been receiving much attention from different research groups. Much of the experimental and theoretical work has been carried out on aqueous systems or in the study of salt effect in vapor-liquid equilibria. However, the design and simulation of unit operations such as, The recently developed extractive crystallization, requires experimental solubility data as well as The ability to correlate and predict electrolyte activity coefficients in mixed-solvents. Moreover, this kind of data can give many relevant indications about ion-solvent interactions and allows the calculation of other thermodynamic properties. Thus, in this work, the solubilities of the salts NaBr and KBr were measured, by an analytical isothermal method, in water, methanol, ethanol and their binary mixed-solvent mixtures, water/methanol, water/ethanol and methanol/ethanol, at temperatures from ambient up to 80 O( The obtained data, were used, together with osmotic and mean ionic molal activity coefficients data available in the literature, to test the capabilities of UNIQUAC-based models for the representation of the thermodynamics properties of these systems. Results are shown and comparisons with other approaches are given

Partial molar volumes of amino acids in aqueous solutions of magnesium chloride

The lack of a deep molecular picture of the interactions which govern the biochemistry of vital processes is still one critical issue in this area, which limits the development of pharmaceutical solutions for diseases induced by biochemical disorders [1] and the improvement of the efficiency of biotechnological processes [2]. In this concern the study of protein-electrolyte interactions is of most importance. Hydrophobic, charged atomic groups and ions are components of almost every biologically important systems, but proteins are so complex that is useful to investigate the interaction of model compounds such as amino acids [3]. In the last decade much attention has been devoted to the partial molar volumes and hydration properties of amino acids in electrolyte solutions, which are the subject of this study

Application of the stretched simulated annealing method in the stability analysis of multicomponent systems using excess gibbs energy models

In this work, the Stretched Simulated Annealing Method was applied to identify the stationary points of the tangent plane distance function defined for the Gibbs energy. The classic excess Gibbs energy Non Random Two Liquid model was used for these studies in several multicomponent mixtures, for which specific numerical difficulties were shown. The results obtained by applying the methodology developed in this work were very satisfactory

Electrolyte effect on the solubility of amino acids in aqueous solutions

The precipitation and crystallization of biomolecules have been widely used for their separation and concentration. The presence of electrolytes in solution may affect significantly the solubilities of biochemicals, which has been used for salt-induced separation of proteins. Although amino acids are among the simplest biochemicals, they have many similarities with more complex biochemicals and are the building block of proteins. So, the study of the electrolyte effect In the solubility of amino acids in water is a good starting point for further developments. Although some studies have been published concerning the measurement and thermodynamic properties modeling of aqueous solutions of amino acids with electrolytes, the information available is very scarce. Therefore, in this work, the solubility of Glycine and OL-Alanine were measured in the temperature range between 25 and 60 °C for aqueous systems of KCI, Na2SO4 and (NH4)2S04, salts most often used in industrial separation processes. A comparison is given with values recently published in the literatures. It was possible to find out big discrepancies, and for the solubility of OL-Alanine in aqueous solutions an inverse dependence with the concentration of the KCI salt was obtained, The new experimental data were used together with information already available concerning the activity coefficients and solubilities, to explore the capabilities of a modified Wilson model, recently developed in our group, for the thermodynamic description of these complex systems. Despite the difficulties that arose for the description of these highly non-ideal systems, the results shown are satisfactory for the correlation of the solubilities

Partial molar volumes of glycine and L-Alanine in aqueous MgSO4 solutions between 278.15 and 308.15 K

In this work, partial molar volumes of glycine and L-alanine in aqueous solutions of magnesium sulphate at (0.0, 0.1, 0.3, 0.7 and 1.0) molal were obtained between 278.15 K and 308.15 K. Additionally, partial molar volumes of transfer at infinite dilution and hydration numbers were calculated. In general, transfer volumes are higher for glycine then L-alanine. From the transfer volumes, it can be concluded that the predominant interactions are pairwise between ions and zwitterionic centers of the amino acids. On the other hand, hydration numbers are higher for L-alanine than glycine. Dehydration of the studied amino acids is observed, rising either temperature or salt molality.This work is supported by project Project PEst-C/EQB/LA0020/2013, financed by FEDER through COMPETE - Programa Operacional Factores de Competitividade and by FCT - Fundação para a Ciência e a Tecnologia. This work was also co-financed by QREN, ON2 and FEDER (Project NORTE-07-0162-FEDER-000050)

The effect of the alcohol content on the solubility of amino acids in aqueous solutions

The solubility of me most simple a-amino acid, glycine, was measured in the temperature range between 25 and 60°C for the aqueous system of ethanol and at 25 °C for the aqueous system 0V 1-propanol. Theoretical work was essentially focused on the application of the excess solubility approach with conventional thermodynamic models such as the Margules and Wilson equations. The simple three suffix Margules model, with only one parameter to be estimated, gave the best results, with an average absolute deviation of 3.8%

Solubility of amino acids in mixed solvent systems

The solubilities of L-serine, L-threonine and L-isoleucine in the aqueous systems of ethanol, 1-propanol and 2-propanol were measured in the temperature range between 298.15 K and 333.15 K by means of a gravimetric method and a spectrophotometric technique based on a ninhydrin reaction. The solubility data from this work and from literature were used to explore the potentialities of the application of the excess solubility approach with the NRTL [1], modified NRTL [2], modified UNIQUAC [3, 4] equations and the model presented by Gude et al. (1996) [5, 6]. These four models give a global average relative deviation of 12.2 %, 12.0 %, 15.1 %, and 16.2 % for correlation and 16.3 %, 14.6 %, 27.3 %, and 22.0 % for prediction, respectively