Triacylglycerols and body fat mass are possible independent predictors of C3 in apparently healthy young Brazilian adults

AbstractObjectiveTo evaluate the association between serum concentrations of complement factor-3 (C3) with anthropometric, biochemical, and lifestyle features in healthy young adults.MethodsFrom 157 young healthy adults 18 to 35 y old, anthropometric measurements and body composition, systolic and diastolic blood pressures, and lifestyle data were collected and analyzed. Blood samples were collected after a 12-h fast for the determination of glucose, triacylglycerols, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, insulin, C3, ceruloplasmin, and uric acid.ResultsComplement factor-3 correlated directly with body mass index (r = 0.23417, P = 0.0032), body fat mass (bioelectrical impedance analysis; r = 0.33407, P < 0.0001), percentage of body fat (bioelectrical impedance analysis; r = 0.26873, P = 0.0007), waist circumference (r = 0.21266, P = 0.0075), insulin (r = 0.26152, P = 0.0009), homeostasis model assessment of insulin resistance (r = 0.24831, P = 0.0017), total cholesterol (r = 0.23335, P = 0.0033), triacylglycerols (r = 0.38435, P < 0.0001), and other outcome measurements. In the multiple linear regression analysis, triacylglycerols (r2 = 0.1379, P < 0.0001) and body fat mass (bioelectrical impedance analysis; r2 = 0.0621, P = 0.0010) were independently associated with the C3 concentration after adjusting for age, gender, smoking status, and physical activity.ConclusionComplement factor-3 seems to be related to several anthropometric and biochemical measurements in healthy young adults. These results demonstrate an independent role of triacylglycerols, a component of the metabolic syndrome, and body fat mass as possible predictors of C3 concentrations. Thus, C3 can be used as an early marker for metabolic syndrome manifestations

Selenium antioxidant effects and its link with inflammation and metabolic syndrome.

O estado inflamat?rio cr?nico e de baixo grau bem como o estresse oxidativo associados ? s?ndrome metab?lica s?o fatores de risco relevantes para o desenvolvimento de doen?as cardiovasculares. Neste contexto, o sel?nio ? um mineral essencial que se encontra associado com o correto funcionamento dos principais processos metab?licos celulares. Estudos in vitro e in vivo em modelos experimentais de s?ndrome metab?lica, bem como em humanos, tem investigado o efeito do sel?nio sobre a express?o e secre??o de biomarcadores de inflama??o e de estresse oxidativo. Para obten??o dos artigos sobre efeitos antioxidantes do sel?nio foram feitas pesquisas nos websites cient?ficos. Na literatura encontramos numerosos artigos sobre os diferentes par?metros modulados pelas concentra??es plasm?ticas de sel?nio, incluindo a prote?na-C reativa, a interleucina-6, o fator de necrose tumoral-?, a interleucina-1??e a prote?na transportadora de retinol-4. Esta revis?o teve por objetivo discutir o papel do sel?nio nos processos inflamat?rios e de estresse oxidativo, associados ? s?ndrome metab?lica.The mild chronic inflammation and oxidative stress associated with metabolic syndrome are relevant risk factors for the development of cardiovascular diseases. In this context, selenium is an essential mineral associated with the correct functioning of the main metabolic processes of the cell. In vitro and in vivo studies in experimental metabolic syndrome models as well as in humans have investigated the effect of selenium on the expression and secretion of inflammation and oxidative stress biomarkers. Articles on the antioxidant effects of selenium were sought in scientific websites. There are a great number of studies in the literature on the different parameters modulated by blood selenium levels, such as C-reactive protein, interleukin-6, tumor necrosisfactor-alpha, interleukin-1 beta and retinol binding protein 4. The objective of this review is to discuss the role of selenium in inflammatory and oxidative stress processes associated with the metabolic syndrome

Nutritional profile of patients hospitalized in an intensive care unit.

Pacientes internados em unidade de terapia intensiva (UTI) s?o mais propensos ?s perdas cal?rico-proteicas durante sua perman?ncia, o que interfere significativamente na recupera??o e consequentemente demora para a alta hospitalar, bem como aumento da taxa de mortalidade. Para isso, a literatura disp?e de v?rios m?todos e ferramentas de avalia??o do estado nutricional para identificar pacientes em risco nutricional ou desnutridos.Patients admitted to the intensive care unit (ICU) are more prone to caloric-protein losses during their stay, which significantly impairs recovery and consequently delays in hospital discharge, as well as an increase in the mortality rate. For this, the literature has several methods and tools for assessing nutritional status to identify patients at nutritional or malnourished risk

Physical exercise as a preventive procedures inflammation of aging

Ao longo do processo de envelhecimento observa-se complexa remodelagem do sistema imunitário. Estas alterações estão associadas ao desenvolvimento de patologias responsáveis por grande parte da mortalidade em população idosa. Recentemente, a prática regular de atividades físicas tem sido proposta como intervenção não-medicamentosa com amplos benefícios sobre a regulação de processos decorrentes da imunossenescênia. Neste sentido, o presente trabalho revisou e discutiu estudos que abordam a ação de mediadores pró-inflamatórios crônicos e possíveis ações do exercício físico como agente antiinflamatório. Baseado nos resultados de estudos na literatura sugere-se que, em conjunto, a interleucina-6 (IL-6) e o fator de necrose tumoral-α (TNF- α) são as principais citocinas associadas à aterosclerose, sarcopenia e déficits cognitivos. Embora os mecanismos não sejam totalmente elucidados, o exercício reduz a atividade de citocinas pró-inflamatórias e aumenta a liberação de substancias anti-inflamatórias.During the aging is observed complex remodeling of immune system. These changes are associated with the development of diseases responsible for much of the mortality in the elderly. Recently, the regular practice of exercise has been proposed as an intervention non-medication with broad benefits on regulation processes arising from Immunosenescence. In sense, this paper reviewed and discussed studies addressing the action of pro-inflammatory mediator's chronic and possible actions of physical exercise as anti-inflammatory agent. Based on the results of studies in the literature suggest that, together, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are the main cytokines associated with atherosclerosis, sarcopenia and cognitive deficits. Though mechanisms are not fully elucidated, the Exercise reduces the activity of pro-inflammatory and increases the release of anti-inflammatory substances