Synthesis and photochemistry of 2,2-di-<i>tert</i>-butyl-6-( 4,4-di-<i>tert</i>-butylbuta-1 ,3-dienyl) -2<i>H</i>-pyran

781-785E,E-1,1,9,9-tetra-tert-butylnona-1,3,6,8-tetraen-5-one 7 undergoes cyclization under both basic and acidic conditions to yield 2,2-di-tert-butyl-6-(4,4-di-tert-butylbuta-1,3-dienyl)-2H-pyran 6. Upon photolysis of the 2H-pyran derivative ring opening to the ketone is observed. The 2H-pyran derivative is fluorescent and its fluorescence quantum yield and life time have been measured in cyclohexane and acetonitrile

Renin-angiotensin-aldosterone system blockers and cardiovascular outcomes: a meta-analysis of randomized clinical trials

Objective: Hypertension is the most prevalent modifiable risk factor for cardiovascular (CV) and cerebrovascular morbidity and mortality. This study aimed to assess the effects of renin-angiotensin-aldosterone system (RAAS) blockade on CV outcomes