14 research outputs found
O Mapa das Cortes: perspectivas cartográficas
O presente trabalho realiza uma análise exaustiva do Mapa das Cortes, aplicando critérios da cartografia, em particular da cartografia matemática. Assim, analisam-se: autor, escala, projeção, meridiano de origem, cores, convenções, simbologia e outros. Após uma análise morfológica qualitativa, passa-se a um exame quantitativo, comparando esse mapa com um atual, bastante preciso: com o auxílio de um programa de cartografia digital e uma planilha eletrônica foram comparadas as coordenadas geográficas (latitude e longitude) de mais de 430 pontos. A quantificação sistemática e detalhada dos erros em diferentes regiões, da costa atlântica à região amazônica, mostrou aspectos surpreendentes de como o Mapa das Cortes (MC) foi habilmente construído. Essa análise permitiu quantificar de maneira mais precisa as distorções, identificando em que locais foram introduzidas e seu caráter indubitavelmente proposital.In this paper, we present a thorough analysis of the Map of the Courts based on criteria used in cartography, particularly mathematical cartography. As such, it takes into account the following elements: author, scale, projection, the prime meridian, colors, conventions, symbology, and other. After a qualitative morphological analysis, we move on to a quantitative examination by comparing the said map with a quite accurate present-day chart, using a digital cartography software application and spreadsheet to match the geographic coordinates (latitude and longitude) of over 430 points. The systematic and detailed quantification of errors in various areas, from the Atlantic coast to the Amazon region, revealed surprising aspects as to how skillfully the Map of the Courts was constructed. This analysis enabled us to quantify the distortions more accurately and thus identify the locations where they were introduced as well their unquestionable intentional character
Hypothalamic S1p/s1pr1 axis controls energy homeostasis
Sphingosine 1-phosphate receptor 1 (S1PR1) is a G-protein-coupled receptor for sphingosine-1-phosphate (S1P) that has a role in many physiological and pathophysiological processes. Here we show that the S1P/S1PR1 signalling pathway in hypothalamic neurons regulates energy homeostasis in rodents. We demonstrate that S1PR1 protein is highly enriched in hypothalamic POMC neurons of rats. Intracerebroventricular injections of the bioactive lipid, S1P, reduce food consumption and increase rat energy expenditure through persistent activation of STAT3 and the melanocortin system. Similarly, the selective disruption of hypothalamic S1PR1 increases food intake and reduces the respiratory exchange ratio. We further show that STAT3 controls S1PR1 expression in neurons via a positive feedback mechanism. Interestingly, several models of obesity and cancer anorexia display an imbalance of hypothalamic S1P/S1PR1/STAT3 axis, whereas pharmacological intervention ameliorates these phenotypes. Taken together, our data demonstrate that the neuronal S1P/S1PR1/STAT3 signalling axis plays a critical role in the control of energy homeostasis in rats.Sphingosine 1-phosphate receptor 1 (S1PR1) is a G-protein-coupled receptor for sphingosine-1-phosphate (S1P) that has a role in many physiological and pathophysiological processes. Here we show that the S1P/S1PR1 signalling pathway in hypothalamic neurons regulates energy homeostasis in rodents. We demonstrate that S1PR1 protein is highly enriched in hypothalamic POMC neurons of rats. Intracerebroventricular injections of the bioactive lipid, S1P, reduce food consumption and increase rat energy expenditure through persistent activation of STAT3 and the melanocortin system. Similarly, the selective disruption of hypothalamic S1PR1 increases food intake and reduces the respiratory exchange ratio. We further show that STAT3 controls S1PR1 expression in neurons via a positive feedback mechanism. Interestingly, several models of obesity and cancer anorexia display an imbalance of hypothalamic S1P/S1PR1/STAT3 axis, whereas pharmacological intervention ameliorates these phenotypes. Taken together, our data demonstrate that the neuronal S1P/S1PR1/STAT3 signalling axis plays a critical role in the control of energy homeostasis in rats5485
Hypothalamic S1p/s1pr1 Axis Controls Energy Homeostasis
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Sphingosine 1-phosphate receptor 1 (S1PR1) is a G-protein-coupled receptor for sphingosine-1-phosphate (S1P) that has a role in many physiological and pathophysiological processes. Here we show that the S1P/S1PR1 signalling pathway in hypothalamic neurons regulates energy homeostasis in rodents. We demonstrate that S1PR1 protein is highly enriched in hypothalamic POMC neurons of rats. Intracerebroventricular injections of the bioactive lipid, S1P, reduce food consumption and increase rat energy expenditure through persistent activation of STAT3 and the melanocortin system. Similarly, the selective disruption of hypothalamic S1PR1 increases food intake and reduces the respiratory exchange ratio. We further show that STAT3 controls S1PR1 expression in neurons via a positive feedback mechanism. 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Rainforest fragmentation and the demography of the economically important palm Oenocarpus bacaba in central Amazonia
Descontruindo mapas, revelando espacializações: reflexões sobre o uso da cartografia em estudos sobre o Brasil colonial
Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats
Cartographic Style in the First Urban Maps of Cadiz, Spain: A Technique in Transition
This article deals with the cartometric analysis of various seventeenth-century urban maps of the city of Cadiz (Spain), from among which the so-called Vista Arámburu and the map belonging to the atlas of the Marquis of Heliche, discovered in the Krigsarkivet (Military Archive) of Stockholm, stand out for their uniqueness. These hitherto relatively unknown documents present evidence of an evolution of cartographic style towards greater topographic accuracy and hence cannot just be considered as simple drawings. In this seventeenth-century period of transition, the cartography of the city evolved from sixteenth-century aerial-view perspectives to the exhaustive planimetric maps of the eighteenth century, made by Spanish and French Military Corps of Engineers. These documents hold great historical value, not only due to the importance of Cadiz during the Modern Age but also because these maps constitute a graphic testimony of the fortification and growth of the city in this period. © 2019 British Cartographic Society