Transdermaalse rasestumisvastase plaastri EVRA kasutamise kogemus Eestis

Uuringu eesmärgiks oli koguda andmeid transdermaalse rasestumisvastase plaastri EVRA kasutamise kohta igapäevatingimustes Eestis. Kokku 442 fertiilses eas naisel hinnati meetodi taluvust, kõrvaltoimeid, efektiivsust, ravisoostumust, meeldivust ja rahulolu. EVRA kasutamisel ilmnes hea ravisoostumus, hea tsükli- ja rasestumiskontroll ning rahulolu meetodiga. EVRA omadused, mis väärisid kõige enam ära -märkimist patsientide poolt, olid kasutamise mugavus ja lihtsus, nädalane kasutamistsükkel, transdermaalne manustamine ja hea taluvus. Neid omadusi tuleb pidada praktikas meelepärase kontratseptiivi valikul oluliseks. Eesti Arst 2007; 86 (1): 19–2

Whole exome sequencing of benign pulmonary metastasizing leiomyoma reveals mutation in the BMP8B gene

Background: Benign metastasizing leiomyoma (BML) is an orphan neoplasm commonly characterized by pulmonary metastases consisting of smooth muscle cells. Patients with BML have usually a current or previous uterine leiomyoma, which is therefore suggested to be the most probable source of this tumour. The purpose of this case report was to determine the possible genetic grounds for pulmonary BML. Case presentation: We present a case report in an asymptomatic 44-year-old female patient, who has developed uterine leiomyoma with subsequent pulmonary BML. Whole exome sequencing (WES) was used to detect somatic mutations in BML lesion. Somatic single nucleotide mutations were identified by comparing the WES data between the pulmonary metastasis and blood sample of the same BML patient. One heterozygous somatic mutation was selected for validation by Sanger sequencing. Clonality of the pulmonary metastasis and uterine leiomyoma was assessed by X-chromosome inactivation assay. Conclusions: We describe a potentially deleterious somatic heterozygous mutation in bone morphogenetic protein 8B (BMP8B) gene (c.1139A > G, Tyr380Cys) that was identified in the pulmonary metastasis and was absent from blood and uterine leiomyoma, and may play a facilitating role in the metastasizing of BML. The clonality assay confirmed a skewed pattern of X-chromosome inactivation, suggesting monoclonal origin of the pulmonary metastases.Peer reviewe

Additional file 3: Figure S1. of Whole exome sequencing of benign pulmonary metastasizing leiomyoma reveals mutation in the BMP8B gene

A non-random X-chromosome inactivation pattern of leiomyoma specimen of the BML patient. HpaII + denotes enzyme-digested DNA and HpaII − means undigested DNA. (PPTX 46 kb

Additional file 1: of Whole exome sequencing of benign pulmonary metastasizing leiomyoma reveals mutation in the BMP8B gene

Supplementary methods. DNA extraction and sequencing. (DOCX 21 kb

Peer Effects and Voluntary Green Building Certification

Empirical evidence is provided to show that peer effects have statistically significant and positive impacts on the diffusion of green building certificates. Application and approval records of green certificates by commercial buildings in NY and AZ are used. The challenge of self-selection is addressed by the usage of fixed effects and the challenge of reflection is addressed by the time lag delay between a building’s application and its approval. Empirical results show that an additional approved LEED certificate within a zip code will increase the probability of a commercial building in the same zip code to apply for a LEED certificate by 3–4 percentage points; an additional approved Energy Star certificate within a zip code will increase the probability of a commercial building in the same zip code to apply for an Energy Star certificate by 1–2 percentage points

Additional file 6: of The influence of menstrual cycle and endometriosis on endometrial methylome

Venn diagrams of differentially methylated genes. Diagrams show the total number of hypo- and hypermethylated genes identified in each comparison. (TIF 3142 kb

Additional file 7: of The influence of menstrual cycle and endometriosis on endometrial methylome

Menstrual cycle phase specific genes. The list of late-secretory and menstrual phase specific hyper- and hypomethylated genes. (XLSX 28 kb

Additional file 3: of The influence of menstrual cycle and endometriosis on endometrial methylome

Differentially methylated regions between different menstrual cycle phases. The methylation data of each menstrual cycle phase was compared to other phases. (XLSX 2676 kb

風俗 金魚傳 第二編

An Edo-period illustrated novel of the gesaku genre.Dimensions: 7 x 4⅝ x ⅛ in. (17.78 x 11.75 x 0.32 cm)Gift of Barry Rosenstee