8 research outputs found
Untersuchungen an der AEROSIL-Elektrolyt-Phasengrenze ohne Anwesenheit von Basenkationen
The Influence of the Choice of a Suitable Dividing Surface on the Results of Surface Charge Density Calculations
Comparison of the iron oxide-based blood-pool contrast medium VSOP-C184 with gadopentetate dimeglumine for first-pass magnetic resonance angiography of the aorta and renal arteries in pigs
Coronary MR Angiography: Experimental Results with a Monomer-stabilized Blood Pool Contrast Medium
Electrical conductivity of dilute and concentrated aqueous dispersions of monodisperse polystyrene particles. Influence of surface conductance and double-layer polarization
Diagnose angeborener Störungen der Thrombozytenfunktion Interdisziplinäre S2K-Leitlinie der Ständigen Kommission Pädiatrie der Gesellschaft für Thrombose- und Hämostaseforschung e. V.
Congenital disorders of platelet function are a heterogeneous group of disorders that are often not detected until bleeding occurs. In clinical settings only a few methods have proven to be useful for identification and classification of inherited platelet disorders. For a rational diagnostic approach, a stepwise algorithm is recommended. Patient history and clinical investigation are mandatory. Von Willebrand disease and other coagulation disorders should always be ruled out prior to specific platelet testing. Platelet count, size, volume (MPV) and morphology may guide further investigations. The PFA-100® CT is suited for screening for severe platelet defects. Platelet aggregometry allows assessment of multiple aspects of platelet function. Flow cytometry enables diagnosis of thrombasthenia Glanzmann, Bernard-Soulier syndrome and storage pool defects. Molecular genetics may confirm a putative diagnosis or pave the way for identifying new defects. We present an unabridged version of the interdisciplinary guideline