effects of temperature, pH and sugar binding on the structures of lectins ebulin f and selfd

Producción CientíficaEbulin f and SELfd are two lectins of Sambucus ebulus L. that show different stability and digestibility properties in gastric fluid due to their structural differences which may explain their different toxicological profiles. The main aim was to determine the effects of pH, temperature and sugar binding on the intrinsic structures of both proteins by fluorescence analyses. Quenching experiments were conducted, under different pH and temperature conditions, with acrylamide (uncharged) and iodide (charged), to study the possible changes of their intrinsic fluorescence. Results revealed that the native structure of SELfd is more folded than that of ebulin f. At pH 2.0, ebulin f displayed a more open structure than at neutral pH. It can be concluded that this is the main reason why ebulin f is accessible to pepsin action and more sensitive to degradation, in contrast to SELfd as we reported previously.Grupo de Excelencia GR106UVa-GIR Inmunotoxinas AntitumoralesConvenio Consejería de Sanidad JCy

A Cross-National Comparison E-government Success Measures: A Theory-Based Empirical Research

The continuing rapid convergence of government and e-technologies presents new opportunities for research to investigate the ways citizens interact with e-government. The literature in the area is, however, still in its infancy with little or no theoretically grounded empirical research conducted in the area. The present research investigates citizen experience with e-government in the United States and Spain by utilizing difference tests. Results of the difference tests show that the Spanish e-government citizens put more emphasis on information quality in terms of relevance, reliability, timeliness, clarity, conciseness, and currency. Results of the difference tests also show that for the system usage construct, e-government citizens on both side of the Atlantic agree that their e-government should provide superior user training, facilitate use of extranets to communicate with governmental agencies, allow automated transmitting and processing of data, and allow real time monitoring of citizen request for information in an e-government integrated with governmental agencies environment

Factores sociodemográficos maternos y asistencia de los niños a los controles de retinopatía de la prematuridad. Hospital regional Lambayeque - 2017

La presente investigación tuvo como objetivo determinar la relación que existe entre los factores sociodemográficos maternos y la asistencia de los niños a los controles de retinopatía de la prematuridad. Hospital Regional Lambayeque – 2017. La investigación es de tipo descriptiva correlacional. El universo muestral estuvo conformado por 147 madres. Para la recolección de los datos se utilizaron dos instrumentos el cuestionario de factores sociodemográficos maternos y el formato de asistencia a los controles retinopatía de la prematuridad. Los resultados que se obtuvieron sobre los factores sociodemográficos fueron que el 25,2% tienen una edad entre 20 a 24 años; el 37,4% tienen el estado civil conviviente; el 31,3% su grado de instrucción es secundaria; el 38,1% tienen un solo hijo; el 37,4% son amas de casa; el 61,2% tienen una estructura familiar nuclear; el 74,1% habitan en un área de residencia urbana y en cuanto al conocimiento el 60,5% es regular. En cuanto a la asistencia de los niños a los controles de retinopatía de la prematuridad, los hallazgos obtenidos son que el 78,2% no asiste y el 21,8% asiste. Al relacionar los factores sociodemográfico maternos y la asistencia de los niños a los controles de retinopatía de la prematuridad, tenemos que solo el factor edad es dependiente de la variable asistencia dado que el valor de chi-cuadrado de Pearson es 9,877 el cual es mayor en relación al 9,45 de la razón de verosimilitud, es decir existe relación significativa sólo en esa variable.This research aimed to determine the relationship between maternal sociodemographic factors and children's attendance at retinopathy controls of prematurity. Lambayeque Regional Hospital - 2017. The research is correlational descriptive. The sample universe was made up of 147 mothers. Two instruments were used to collect the data: the maternal sociodemographic factors questionnaire and the retinopathy of prematurity control assistance format. The results obtained on the sociodemographic factors were that 25.2% are between 20 and 24 years old; 37.4% have a cohabiting civil status; 31.3% their educational level is secondary; 38.1% have a single child; 37.4% are housewives; 61.2% have a nuclear family structure; 74.1% live in an urban residence area and, as for knowledge, 60.5% is regular. Regarding children's attendance at retinopathy controls of prematurity, the obtained results are that 78.2% do not attend and 21.8% attend. When relating maternal sociodemographic factors and children's attendance to retinopathy controls of prematurity, we have that only the age factor is dependent on the assistance variable since the Pearson's chi-square value is 9,877, which is higher in relation to the 9.45 of the likelihood ratio, that is, there is a significant relationship only in that variable.Tesis de segunda especialida

Devices for Prevention of Atrial Tachyarrhythmias

Atrial fibrillation (AF) is the most frequent sustained cardiac arrhythmia in clinical practice and, although its importance has been underestimated even in recent years, we are now becoming aware of its clinical transcendence1,2,3. The classical treatment is pharmacological, but its efficacy is limited and it does have side effects4,5. Therefore, in recent years, there has been an increasing interest in other types of non-pharmacological treatments6,7. Physiologic cardiac pacing has proven to be more effective than VVI mode pacing to prevent the occurrence of AF during the follow-up of patients who have had a permanent pacemaker implanted 8,9,10. There are currently different lines of research that use different atrial pacing techniques to prevent and treat episodes of paroxysmal atrial fibrillation11,12. Techniques of multi-site pacing in the right atrium or both atria, new atrial pacing sites, prevention algorithms for paroxysmal atrial fibrillation episodes, and even high-frequency atrial tachyarrhythmia termination algorithms have all been proposed. In this article, we will try to synthesize the grounds for and findings of the different lines of research currently being developed

Determinants of trading activity after rating actions in the Corporate Debt Market

The influence of rating announcements on corporate debt market trading has been previously overlooked. Based on an event study, we examine the effects of the three types of announcements provided by credit rating agencies on abnormal trading volume and trading frequency in the Spanish corporate debt market. Additionally, by means of cross-section regressions, we establish what factors determine the sign and intensity of the trading reactions. The presented results indicate that factors related to the characteristics of the rating announcement, the issuing company and the economic environment are relevant in light of several hypotheses.Rating agencies, Rating announcementes, Trading volume, Trading frequency

Eficiencia tributaria con la dación del Decreto Legislativo Nº 1264-repatriación de capitales en la recaudación tributaria en la región Lambayeque durante el año 2017

El tema la recaudación tributaria es un problema que agobia con respecto al bajo nivel de ingresos que se reciben para el financiamiento de las actividades del Estado, es por eso que se estableció y se aprobó un Régimen Temporal y Sustitutorio del Impuesto a la Renta (IR) para aquellos contribuyentes domiciliados que declaren, repatríen e inviertan en el Perú con beneficios de reducción de tasas y menos trámites documentarios. De tal forma, el presente trabajo de investigación tiene como objetivo general evaluar si con la dación del Decreto Legislativo Nº 1264 se ha obtenido eficiencia tributaria en la Recaudación Tributaria en la Región Lambayeque durante el año 2017. Así mismo, tendrá como población a los principales contribuyentes de la Intendencia Regional Lambayeque – SUNAT, donde se aplicará el método teórico que permitió hacer una serie de investigaciones referentes al problema y a la vez tener contacto directo con la Incidencia Regional Lambayeque – SUNAT. Las técnicas para la recolección de datos que se utilizaron en la presente investigación fueron las de observación y encuesta y los instrumentos de recolección fueron el análisis documental y el cuestionario para una mejor información sobre la población encuestada. Se concluyó que la dación del Decreto Legislativo Nº 1264 no fue eficiente ya que no llegó a cumplir las metas establecidas. Se recomienda a las entidades o instituciones representativas fiscalizadoras o recaudadoras a la mayor difusión de este tipo de incentivos

Credit Rating Announcements, Trading Activity and Yield Spreads: The Spanish Evidence

We test whether or not different rating announcements contain pricing-relevant information and modify trading activity patterns in the Spanish commercial paper and corporate bond markets. We observe a statistically significant widening of yield spreads in both segments of the corporate debt market after reviews of downgrades and negative outlook reports. In addition, we find that certain rating announcements encourage trading activity even when the information is not pricing-relevant. The release of information arouses investor interest for the involved securities. Thus, trading frequency increases, although larger-sized transactions, which should denote possible portfolio rebalancing, are not observed. In the commercial paper note market, we also find that that trading volumes fade away after reviews for downgrade. Investors seem to prefer reducing the trading of these short-term securities to liquidating their positions.Credit rating agencies, Rating changes, Event study, Yields, Liquidity, Trading frequency, Corporate bond market, Commercial paper market.

Applying multilevel model to the relationship of dietary patterns and colorectal cancer: An ongoing case-control study in Córdoba, Argentina

Scientific literature has consistently shown the effects of certain diets on health but regional variations of dietary habits, and their relationship colorectal cancer (CRC) has been poorly studied in Argentina. Our aims were to identify dietary patterns and estimate their effect on CRC occurrence and to quantify the association between family history of CRC and CRC occurrence by applying multilevel models to estimate and interpret measures of variation. Methods: Principal components factor analysis was performed to identify dietary patterns that were then used in a multilevel logistic regression applied to an ongoing case-control data about dietary exposure and CRC occurrence taking into account familiar clustering. Results: Three dietary patterns were identified: "Southern Cone pattern" (red meat, wine, and starchy vegetables), "High-sugar drinks pattern", and "Prudent pattern". The study considered 41 cases and 95 controls. There was a significant promoting effects on CRC of "Southern Cone" (OR 1.5, 95%CI 1.0-2.2) and "High-sugar drinks" (OR 3.8, 95%CI 2.0-7.1) patterns, whereas "Prudent pattern" (OR 0.3, 95%CI 0.2-0.4) showed a significant protective effect at third tertile level. BMI, use of NSAIDs, and to have medical insurance showed significant effects. Variance of the random effect of family history of CRC was highly significant. Conclusions: This novel approach for Argentina showed that Southern Cone and High-sugar drinks patterns were associated with a higher risk of CRC, whereas the Prudent pattern showed a protective effect. There was a significant clustering effect of family history of CRC.Fil: Pou, Sonia Alejandra. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición. Cátedra de Estadística y Bioestadística; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Diaz, Maria del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; ArgentinaFil: Osella, Alberto Rubén. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición. Cátedra de Estadística y Bioestadística; Argentin

Perdón interpersonal: validación del Enright Forgiveness Inventory (EFI-30) en una muestra española

Background: Numerous studies have demonstrated the importance of interpersonal forgiveness after a specific offense for improving the health and well-being of individuals. Despite its importance, there is an evident lack of forgiveness evaluation instruments adapted to the Spanish context. The Enright Forgiveness Inventory (EFI-30) is the questionnaire that implements one of themost establishedand recognized theoretical models in thearea offorgiveness. The aim of the present study is to adapt the EFI-30 for the Spanish population and evaluate its psychometric properties. Method: A sample of 426 undergraduate and graduate students (98 men, 328 women) aged from 18 to 30 years (M= 21.24; SD=2.91), completed the EFI-30 after its adaptation to the Spanishcontext, as well as the Transgression Related Interpersonal Motivations Inventory (TRIM-18), the Remedial Strategies Scale (RSS) and the Depression Anxiety and Stress Scale (DASS-21). Results: The Confirmatory Factor Analysis showed a good fit tothe original six-factor structure (CFI=.91, TLI=.90, IFI=.91, RMSEA= .067). The reliability of these subscales and the instrument was similar to the original version. The results showed adequate criteria and convergent validity. Conclusions: The EFI-30 shows adequate psychometric properties within the Spanish context and is an appropriate instrument for evaluating interpersonal forgiveness of a specific offense in research and clinical intervention.Antecedentes: Diversos estudios demuestran la relevancia del perdón interpersonal tras una ofensa para mejorar la salud y el bienestar. A pesar de su importancia, es evidente la falta de instrumentos de evaluación del perdón adaptados al contexto español. El Enright Forgiveness Inventory (EFI-30) es el instrumento que operacionaliza uno de los modelos teóricos más asentados y reconocidos en el área del perdón a nivel mundial. El objetivo del presente estudio es adaptar el EFI-30 a la población española y revisar sus propiedades psicométricas. Método: 426 estudiantes de grado y máster (98 hombres y 328 mujeres) con edades entre 18 y 30 años (M= 21.24; DE= 2.91), completaron el EFI-30 tras su adaptación, así como Transgression Related Interpersonal Motivations Inventory (TRIM-18), Remedial Strategies Scale (RSS) y Depression Anxiety and Stress Scale (DASS-21). Resultados: El Análisis Factorial Confirmatorio indicó buen ajuste a la estructura original de seis factores (CFI=.91, TLI=.90, IFI=.91, RMSEA= .067). La fiabilidad de las subescalas y del instrumento general fue buena, similar a la versión original. Los resultados mostraron adecuada validez convergente y de criterio. Conclusiones:EFI-30 muestra adecuadas propiedades psicométricas en un contexto español, siendo una medida apropiada para evaluar el perdón interpersonal de una ofensa especifica en al ámbito de la investigación e intervención clínica

Agresividad y personalidad en investigados por violencia contra la mujer de la Provincia de Chota Cajamarca

El presente informe expone el estudio que tuvo por finalidad determinar la relación entre agresividad y personalidad en investigados por delito de violencia contra la mujer de la provincia Chota – Cajamarca, el cual se realizó mediante una metodología de tipo cuantitativa, correlacional y no experimental, a una muestra de 115 hombres evaluados con el “Cuestionario de Agresividad AQ29” y el “Cuestionario de Personalidad de Eysenck EPQ-R”, siendo ambos instrumentos validados. Se determinó en base a los resultados relación significativa (p<0.01) entre agresividad y personalidad; asimismo, se determinó relación significativa entre agresividad y las dimensiones de personalidad: neuroticismo, extroversión y psicoticismo.TesisComunicación y desarrollo human