Significant and persistent improvements in time in range and positive emotions in children and adolescents with type 1 diabetes using a closed-loop control system after attending a virtual educational camp

Objective To evaluate the six-month impact of the advanced automated functions of a closed-loop control (CLC) system (Control-IQ) and a virtual educational camp (vEC) on emotions and time in range (TIR) of children and adolescents with type 1 diabetes. Methods Children and their parents participated in a three-day vEC. Clinical, glucose, and emotion data were evaluated before, just after, and six months after the vEC. Emotions were evaluated using adapted Plutchik's and Geneva Emotion Wheels. Results Forty-three children and adolescents (7-16 years) showed significant improvements in positive emotions immediately and six months after the vEC (67% and 65% vs 38%, p < 0.05, respectively), while mixed emotions were reduced (32% and 15% vs 61%, p < 0.05 and p < 0.001, respectively). The median percentage TIR increased from 64% (IQR 54-72) to 75% (IQR 70-82) with Control-IQ (p < 0.001) six months after the vEC. Conclusions Positive emotions (joy, serenity, and satisfaction) significantly improved while mixed emotions were significantly worse six months after the initiation of a CLC system (Control-IQ) and a vEC

Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study

none41noAim: To evaluate the impact of a virtual educational camp (vEC) on glucose control in children and adolescents with type 1 diabetes using a closed-loop control (CLC) system. Materials and Methods: This was a prospective multicentre study of children and adolescents with type 1 diabetes using the Tandem Basal-IQ system. Insulin pumps were upgraded to Control-IQ, and children and their parents participated in a 3-day multidisciplinary vEC. Clinical data, glucose metrics and HbA1c were evaluated over the 12 weeks prior to the Control-IQ update and over the 12 weeks after the vEC. Results: Forty-three children and adolescents (aged 7-16 years) with type 1 diabetes and their families participated in the vEC. The median percentage of time in target range (70-180 mg/dL; TIR) increased from 64% (interquartile range [IQR] 56%-73%) with Basal-IQ to 76% (IQR 71%-81%) with Control-IQ (P <.001). After the vEC, more than 75% of participants achieved a TIR of more than 70%. The percentage of time between 180 and 250 mg/dL and above 250 mg/dL decreased by 5% (P <.01) and 6% (P <.01), respectively, while the time between 70 and 54 mg/dL and below 54 mg/dL remained low and unaltered. HbA1c decreased by 0.5% (P <.01). There were no episodes of diabetic ketoacidosis or severe hypoglycaemia. Conclusions: In this study of children managing their diabetes in a real-world setting, more than 75% of children who participated in a vEC after starting a CLC system could obtain and maintain a TIR of more than 70%. The vEC was feasible and resulted in a significant and persistent improvement in TIR in children and adolescents with type 1 diabetes.noneCherubini V.; Rabbone I.; Berioli M.G.; Giorda S.; Lo Presti D.; Maltoni G.; Mameli C.; Marigliano M.; Marino M.; Minuto N.; Mozzillo E.; Piccinno E.; Predieri B.; Ripoli C.; Schiaffini R.; Rigamonti A.; Salzano G.; Tinti D.; Toni S.; Zanfardino A.; Scaramuzza A.E.; Gesuita R.; Tiberi V.; Savastio S.; Pigniatiello C.; Trada M.; Zucchini S.; Redaelli F.C.; Maffeis C.; Bassi M.; Rosanio F.M.; Delvecchio M.; Buzzi P.; Ricciardi M.R.; Carducci C.; Bonfanti R.; Lombardo F.; Piccini B.; Iafusco D.; Calandretti M.; Daga F.A.Cherubini, V.; Rabbone, I.; Berioli, M. G.; Giorda, S.; Lo Presti, D.; Maltoni, G.; Mameli, C.; Marigliano, M.; Marino, M.; Minuto, N.; Mozzillo, E.; Piccinno, E.; Predieri, B.; Ripoli, C.; Schiaffini, R.; Rigamonti, A.; Salzano, G.; Tinti, D.; Toni, S.; Zanfardino, A.; Scaramuzza, A. E.; Gesuita, R.; Tiberi, V.; Savastio, S.; Pigniatiello, C.; Trada, M.; Zucchini, S.; Redaelli, F. C.; Maffeis, C.; Bassi, M.; Rosanio, F. M.; Delvecchio, M.; Buzzi, P.; Ricciardi, M. R.; Carducci, C.; Bonfanti, R.; Lombardo, F.; Piccini, B.; Iafusco, D.; Calandretti, M.; Daga, F. A