Relevance of electron spin dissipative processes to dynamic nuclear polarization via thermal mixing

The available theoretical approaches aiming at describing Dynamic Nuclear spin Polarization (DNP) in solutions containing molecules of biomedical interest and paramagnetic centers are not able to model the behaviour observed upon varying the concentration of trityl radicals or the polarization enhancement caused by moderate addition of gadolinium complexes. In this manuscript, we first show experimentally that the nuclear steady state polarization reached in solutions of pyruvic acid with 15 mM trityl radicals is substantially independent from the average internuclear distance. This evidences a leading role of electron (over nuclear) spin relaxation processes in determining the ultimate performances of DNP. Accordingly, we have devised a variant of the Thermal Mixing model for inhomogenously broadened electron resonance lines which includes a relaxation term describing the exchange of magnetic anisotropy energy of the electron spin system with the lattice. Thanks to this additional term, the dependence of the nuclear polarization on the electron concentration can be properly accounted for. Moreover, the model predicts a strong increase of the final polarization on shortening the electron spin-lattice relaxation time, providing a possible explanation for the effect of gadolinium doping.Comment: 13 pages, 12 figure

Role of the glassy dynamics and thermal mixing in the dynamic nuclear polarization and relaxation mechanisms of pyruvic acid

The temperature dependence of $^1$H and $^{13}$C nuclear spin-lattice relaxation rate $1/T_1$ has been studied in the 1.6 K - 4.2 K temperature range in pure pyruvic acid and in pyruvic acid containing trityl radicals at a concentration of 15 mM. The temperature dependence of $1/T_1$ is found to follow a quadratic power law for both nuclei in the two samples. Remarkably the same temperature dependence is displayed also by the electron spin-lattice relaxation rate $1/T_{1e}$ in the sample containing radicals. These results are explained by considering the effect of the structural dynamics on the relaxation rates in pyruvic acid. Dynamic nuclear polarization experiments show that below 4 K the $^{13}$C build up rate scales with $1/T_{\text{1e}}$, in analogy to $^{13}$C $1/T_1$ and consistently with a thermal mixing scenario where all the electrons are collectively involved in the dynamic nuclear polarization process and the nuclear spin reservoir is in good thermal contact with the electron spin system.Comment: 14 pages, 13 figure

An Architecture for Declarative Real-Time Scheduling on Linux

This paper proposes a novel framework and programming model for real-time applications supporting a declarative access to real-time CPU scheduling features that are available on an operating system. The core idea is to let applications declare their temporal characteristics and/or requirements on the CPU allocation, where, for example, some of them may require real-time POSIX priorities, whilst others might need resource reservations through SCHED_DEADLINE. The framework can properly handle such a set of heterogeneous requirements configuring an underlying multi-core platform so to exploit the various scheduling disciplines that are available in the kernel, matching applications requirements. The framework is realized as a modular architecture in which different plugins handle independently certain real-time scheduling features within the underlying kernel, easing the customization of its behavior to support other schedulers or operating systems by adding further plugins

Scheduling Replica Voting in Fixed-Priority Real-Time Systems

Reliability and safety are mandatory requirements for safety-critical embedded systems. The design of a fault-tolerant system is required in many fields (e.g., railway, automotive, avionics) and redundancy helps in achieving this goal. Redundant systems typically leverage voting techniques applied to the outputs produced by tasks to detect and even tolerate failures. This paper studies the integration of distributed voting protocols in fixed-priority real-time systems from a scheduling perspective. It analyzes two scheduling strategies for implementing voting. One is attractive and friendly for software developers and based on suspending the task execution until the replica provides the data to be voted. The other one is inspired by the Logical Execution Time (LET) paradigm and requires introducing additional tasks in the system to accomplish voting-related activities. Queuing and delays introduced by inter-replica communication interfaces are also analyzed. Experimental results are finally presented to compare the two strategies, showing that LET-inspired voting is much more predictable and hence more suitable than the other strategy for fixed-priority real-time systems

Environmental Pollution and Peripheral Artery Disease

Peripheral artery disease (PAD) of the lower limbs represents one of the most important clinical conditions among vascular disease and can negatively impact quality of life of affected patients, representing also an important socioeconomic burden. Several risk factors predispose to PAD and its complications. Nevertheless, the role of pollution in this context has not been fully evaluated and this article explored the most updated information on epidemiology and environmental pollution in order to hypothesize the possible contribution of air pollution in the onset of PAD. Pollution is an important problem for the global community and has harmful effects on human health and cardiovascular system, and, specifically, particulate matter 10 (PM10) was found significantly associated with PAD

Equivalent modelling of reciprocating engines generators for microgrid frequency response analysis

Typical microgrid configurations include small-scale generation units that belong to the class of reciprocating engines (gas, diesel, heavy fuel oil). A simplified equivalent model for representing the frequency response of a given set of this kind of generators is proposed in this paper. The model parameters are tuned to obtain frequency responses compliant with the performance classes stated by the ISO 8528-5 standard. The result is a set of equivalent and simple models that can be used to simulate the frequency response within a given microgrid configuration that includes a set of reciprocating engines generators. Finally, a suitable validation of the proposed models is carried out using two highly detailed models of real diesel and heavy fuel oil generators

Propeller geometry optimization for pressure pulses reduction: an analysis of the influence of the rake distribution

The evaluation of pressure pulses is a current issue for any high-performance propeller design. It has been addressed experimentally, by means of model tests, and numerically but in most cases the analysis has been limited to the verification of a given geometry (or, at least of few configurations) identified at the end of a traditional design loop. A more direct inclusion of pressure pulses evaluation in the design procedure, for instance by very attractive multi-objective optimization approaches, could be beneficial, especially if more accurate codes may be exploited. Among the others, BEM represent an acceptable compromise between computational costs and accuracy with the further advantage, with respect to lower fidelity approaches, to account for effects of geometrical haracteristics (such as rake distribution) which are often defined only according to designer experience and special needs. However, if the ability of the BEM methods to predict propeller performance and cavitation extension is well documented, the direct computation of pressure pulses may be less reliable, especially in correspondence to heavy cavitating conditions, requiring further validations in particular when the influence of characteristics such as rake distribution, hardly addressed in literature also from the experimental point of view, are considered. Cavitation tunnel test, BEM and RANS calculations have been consequently carried out for two propellers, designed for the same functioning conditions with different rake distributions, in order to stress the capabilities and the limitations of the numerical approaches in dealing with cavitation, pressure pulses predictions and the capability to discriminate between slightly different geometries in the light of their possible application in a design by optimization procedure

shear modulus of masonry walls a critical review

Abstract In the assessment of seismic performance of masonry buildings, the proper definition of mechanical parameters of masonry, the shear modulus in particular, is a critical issue. Moreover, considering that existing buildings are characterized by several masonry types, depending on the material as well as on the texture, mechanical parameters can vary in a very wide range, also because they depend on many other parameters and in particular on the integrity of the walls and on the stress level. Although the in situ or laboratory experimental evaluation of the G modulus has been the subject of a wide literature concerning flat jacks, diagonal and single compression and shear-compression test results, its outcomes are often contradictory. In effect, values given by different studies often differ significantly, even for the same class of masonry. Since the intrinsic scattering of the parameter is not sufficient by itself to justify the huge variability of the results, a critical discussion of the results as well as of the individual test arrangements is necessary to make the background more reliable, also in view of better addressing further studies- A huge database has been setup combining masonry test results available in the relevant scientific literature with the test results obtained in the framework of the in situ experimental campaign carried out by the authors for the assessment of seismic vulnerability of masonry school buildings in the Municipality of Florence. The analysis of the database underlines that values of the shear modulus G, which is a fundamental parameter for the definition of capacity curve for walls commonly used in non-linear static analysis, are extremely scattered. Testing methodology and arrangement are discussed and a possible procedure is proposed to arrive to sounder estimations of relevant mechanical parameter of existing building masonry