6. Oceanapins A-F, unique branched ceramides isolated from the haplosclerid sponge Oceanapia cf. tenuis of the Coral sea

A series of ceramides, called oceanapins A-F (2-7), which are unique for branching at both the sphingosine and fatty-acid chains, have been isolated as pure compounds from the haplosclerid sponge #Oceanapia cf. #tenuis of the Coral Sea. Following acid hydrolysis, both the fatty-acid and the sphingosine portions were obtained separately, which allowed their unequivocal structural definition. The absolute configuration was secured via proctection of C (1')-OH and Mosher's esterification at C (3')-OH of the oceanapins. (Résumé d'auteur

PER UN PROCESSO CIVILE DAVVERO TELEMATICO

Il contributo fornisce alcuni spunti per una informatizzazione "spinta" e di immediata attuazione del processo civile

SPIGOLATURE PROCESSUALI INTORNO A CASS., SS.UU., 14 aprile 2021 n. 9839

Il contributo analizza le ricadure processuali dell'ultimo arresto delle SS.UU. in tema di impugnaizone delle delibere condominiali

Alternative energy storage options for heat pump water heater coupled with photovoltaic plant for domestic hot water production

The present work relies on the topic of energy storage for Heat and Electricity applied to Heat Pump Water Heaters coupled with photovoltaic plants for Domestic Hot Water production. The main idea is to evaluate the possibility to exploit the water tank as heat storage for the produced photovoltaic energy and, where appropriate combined with electrical storage. For this reason, two heat pumps with different volume size have been chosen and smart control strategies have been applied while monitoring the water temperature in the tank. Calculations account on tapping profile inferred from monitored data of a representative end-user in a Mediterranean small island. Results show how the combination of smart control strategies and battery systems is the most suitable solution in order to fulfil the domestic hot water energy demand by renewable sources while maintaining comfort requirements

Introducing Solar Thermal "Net Metering" in an Actual small-scale District Heating System: A Case-study Analysis☆

Abstract An energy and economic analysis on an hypothesis of introduction of prosumers in an actual small-scale district heating system (DHS) in Northern Italy has been carried out. The study was performed by means of dynamic simulations of the DHS. The investigated configurations include the transformation of one or more customers in prosumers, producing and self-consuming solar thermal heat, and supplying the DHS with the excess heat produced. For the considered case-study the solar heat fed into the DHS is basically antagonist of the CHP production. This leads to a decrease in the non-renewable energy share for the whole DHS, to a decrease in the profit of the DHS utility and to a profitable investment for the prosumers

DMBT1 expression is down-regulated in breast cancer.

BACKGROUND: We studied the expression of DMBT1 (deleted in malignant brain tumor 1), a putative tumor suppressor gene, in normal, proliferative, and malignant breast epithelium and its possible relation to cell cycle. METHODS: Sections from 17 benign lesions and 55 carcinomas were immunostained with anti DMBT1 antibody (DMBTh12) and sections from 36 samples, were double-stained also with anti MCM5, one of the 6 pre-replicative complex proteins with cell proliferation-licensing functions. DMBT1 gene expression at mRNA level was assessed by RT-PCR in frozen tissues samples from 39 patients. RESULTS: Normal glands and hyperplastic epithelium in benign lesions displayed a luminal polarized DMBTh12 immunoreactivity. Normal and hyperplastic epithelium adjacent to carcinomas showed a loss of polarization, with immunostaining present in basal and perinuclear cytoplasmic compartments. DMBT1 protein expression was down-regulated in the cancerous lesions compared to the normal and/or hyperplastic epithelium adjacent to carcinomas (3/55 positive carcinomas versus 33/42 positive normal/hyperplastic epithelia; p = 0.0001). In 72% of cases RT-PCR confirmed immunohistochemical results. Most of normal and hyperplastic mammary cells positive with DMBTh12 were also MCM5-positive. CONCLUSIONS: The redistribution and up-regulation of DMBT1 in normal and hyperplastic tissues flanking malignant tumours and its down-regulation in carcinomas suggests a potential role in breast cancer. Moreover, the concomitant expression of DMTB1 and MCM5 suggests its possible association with the cell-cycle regulation