Discrimination of form in images corrupted by speckle

The problem investigated is that of a human observer having to distinguish between certain specified geometrical forms corrupted by speckle-an idealization of the problem of a scientist studying a synthetic aperture radar map. Specifically, the cases of two simple alternative forms and of two and four orientations of a simple form have been considered. A theoretical model is developed for the observer's decision process by analogy with optimal receiver theory, and the probability of a correct decision is related to form parameters like size, contrast, and looks. These calculations are verified by psychophysical experiments using computer-simulated pictures

Effect of pixel dimensions on SAR picture quality

In an SAR mapping system, the product of looks per pixel and number of pixels in the scene is kept constant. Assuming that the returns from all resolution cells obey Rayleigh statistics, the expression for pixel SNR incorporating both speckle and additive white Gaussian noise was derived. It is shown that it is possible to use fine resolution and leave the large-area estimate slightly but not much worse than if a larger pixel size had been initially decided upon

Are animal models of addiction useful?

Background: Preclinical research involving non-human animals has made important contributions to our understanding of risk-factors for addiction, neuroadaptations that follow chronic drug exposure, and to the development of some efficacious pharmacotherapies for addiction. Despite these contributions, we argue that animal models of addiction have impeded progress in our understanding of addiction and its treatment in humans. Argument: First of all, the majority of pharmacological treatments that were initially developed using animal models have failed to prove effective for the treatment of addiction in humans, resulting in a huge waste of resources. Secondly, we demonstrate that prevailing animal models that portray addiction as a disorder of compulsion and habit cannot be reconciled with observations that psychoactive drug use in humans is a goal-directed operant behaviour that remains under the control of its consequences, even in people who are addicted. Thirdly, addiction may be a uniquely human phenomenon that is dependent on language, which necessarily limits the validity of animal models. Finally, we argue that addicted brains must be understood as one component of broader networks of symptoms and environmental and social factors that are impossible to model in laboratory animals. Conclusions: A case can be made that animal models of addiction have not served us well in understanding and treating addiction in humans. It is important to reconsider some widely-held beliefs about the nature of addictive behaviour in humans that have arisen from the zeal to translate observations of laboratory animals

Nucleic Acid Sequence Design via Efficient Ensemble Defect Optimization

We describe an algorithm for designing the sequence of one or more interacting nucleic acid strands intended to adopt a target secondary structure at equilibrium. Sequence design is formulated as an optimization problem with the goal of reducing the ensemble defect below a user-specified stop condition. For a candidate sequence and a given target secondary structure, the ensemble defect is the average number of incorrectly paired nucleotides at equilibrium evaluated over the ensemble of unpseudoknotted secondary structures. To reduce the computational cost of accepting or rejecting mutations to a random initial sequence, candidate mutations are evaluated on the leaf nodes of a tree-decomposition of the target structure. During leaf optimization, defect-weighted mutation sampling is used to select each candidate mutation position with probability proportional to its contribution to the ensemble defect of the leaf. As subsequences are merged moving up the tree, emergent structural defects resulting from crosstalk between sibling sequences are eliminated via reoptimization within the defective subtree starting from new random subsequences. Using a Θ(N^3) dynamic program to evaluate the ensemble defect of a target structure with N nucleotides, this hierarchical approach implies an asymptotic optimality bound on design time: for sufficiently large N, the cost of sequence design is bounded below by 4/3 the cost of a single evaluation of the ensemble defect for the full sequence. Hence, the design algorithm has time complexity Ω(N^3). For target structures containing N ∈{100,200,400,800,1600,3200} nucleotides and duplex stems ranging from 1 to 30 base pairs, RNA sequence designs at 37°C typically succeed in satisfying a stop condition with ensemble defect less than N/100. Empirically, the sequence design algorithm exhibits asymptotic optimality and the exponent in the time complexity bound is shar

Introducing a new method for efficient visualization of complex shape 3D ultrasonic phased-array C-scans

Automated robotic inspection systems allow the collection of large data volumes, compared to existing inspection systems. To maximize the throughput associated with the nondestructive evaluation phase, it is crucial that the reconstructed inspection data sets are generated and examined rapidly without a loss of detail. Data analysis often becomes the bottleneck of automated inspections. Therefore, new data visualization tools, suitable to screen the NDT information obtained through robotic systems, are urgently required. This paper presents a new approach, for the generation of three-dimensional ultrasonic C-scans of large and complex parts, suitable for application to high data throughput ultrasonic phased array inspection. This approach produces 3D C-scan presented as colored tessellated surfaces and the approach works efficiently on challenging geometry, with concave and convex regions. Qualitative and quantitative results show that the approach runs up to 500 times faster than other C-scan visualization techniques

The surface accessibility of the glycine receptor M2-M3 loop is increased in the channel open state

Mutations in the extracellular M2-M3 loop of the glycine receptor (GlyR) alpha1 subunit have been shown previously to affect channel gating. In this study, the substituted cysteine accessibility method was used to investigate whether a structural rearrangement of the M2-M3 loop accompanies GlyR activation. All residues from R271C to V277C were covalently modified by both positively charged methanethiosulfonate ethyltrimethylammonium (MTSET) and negatively charged methanethiosulfonate ethylsulfonate (MTSES), implying that these residues form an irregular surface loop. The MTSET modification rate of all residues from R271C to K276C was faster in the glycine-bound state than in the unliganded state. MTSES modification of A272C, L274C, and V277C was also faster in the glycine-bound state. These results demonstrate that the surface accessibility of the M2-M3 loop is increased as the channel transitions from the closed to the open state, implying that either the loop itself or an overlying domain moves during channel activation

Unconventional carrier-mediated ferromagnetism above room temperature in ion-implanted (Ga, Mn)P:C

Ion implantation of Mn ions into hole-doped GaP has been used to induce ferromagnetic behavior above room temperature for optimized Mn concentrations near 3 at.%. The magnetism is suppressed when the Mn dose is increased or decreased away from the 3 at.% value, or when n-type GaP substrates are used. At low temperatures the saturated moment is on the order of one Bohr magneton, and the spin wave stiffness inferred from the Bloch-law T^3/2 dependence of the magnetization provides an estimate Tc = 385K of the Curie temperature that exceeds the experimental value, Tc = 270K. The presence of ferromagnetic clusters and hysteresis to temperatures of at least 330K is attributed to disorder and proximity to a metal-insulating transition.Comment: 4 pages, 4 figures (RevTex4

Detection of gratings and small features in speckle imagery

The extent of picture degradation of speckle, in particular in synthetic aperture radar pictures, has been investigated in the cases where an observer has to detect (a) a small feature immersed in a darker background, and (b) a square wave grating. In each case, a theoretical model is developed for the observer's detection mechanism, and the probability of correct decision is related to relevant picture parameters such as contrast, looks per pixel, and size. These calculations are verified by psychophysical experiments using computer-simulated pictures. Detectability of gratings as a criterion for characterizing picture quality is shown to be far inferior to feature detectability