Evidence for mass accretion driven by spiral shocks onto the white dwarf in SDSS J123813.73–033933.0

We present high-time-resolution photometry and phase-resolved spectroscopy of the short-period (⁠Porb=80.52min⁠) cataclysmic variable SDSS J123813.73–033933.0, observed with the Hubble Space Telescope (HST), the Kepler/K2 mission, and the Very Large Telescope (VLT). We also report observations of the first detected superoutburst. SDSS J1238–0339 shows two types of variability: quasi-regular brightenings recurring every ≃8.5  h during which the system increases in brightness by ≃0.5mag, and a double-hump quasi-sinusoidal modulation at the orbital period. The detailed K2 light curve reveals that the amplitude of the double-humps increases during the brightenings and that their phase undergoes a ≃90° phase shift with respect to the quiescent intervals. The HST  data unambiguously demonstrate that these phenomena both arise from the heating and cooling of two relatively large regions on the white dwarf. We suggest that the double-hump modulation is related to spiral shocks in the accretion disc resulting in an enhanced accretion rate heating two localized regions on the white dwarf, with the structure of the shocks fixed in the binary frame explaining the period of the double humps. The physical origin of the 8.5  h brightenings is less clear. However, the correlation between the observed variations of the amplitude and phase of the double-humps with the occurrence of the brightenings is supportive of an origin in thermal instabilities in the accretion disc

Constraining the evolution of cataclysmic variables via the masses and accretion rates of their underlying white dwarfs

We report on the masses (MWD), effective temperatures (⁠Teff⁠) and secular mean accretion rates (⁠⟨M˙⟩⁠) of 43 cataclysmic variable (CV) white dwarfs, 42 of which were obtained from the combined analysis of their Hubble Space Telescope ultraviolet data with the parallaxes provided by the Early Third Data Release of the Gaia space mission, and one from the white dwarf gravitational redshift. Our results double the number of CV white dwarfs with an accurate mass measurement, bringing the total census to 89 systems. From the study of the mass distribution, we derive ⟨MWD⟩=0.81+0.16/−0.20M⊙⁠, in perfect agreement with previous results, and find no evidence of any evolution of the mass with orbital period. Moreover, we identify five systems with MWD < 0.5M⊙, which are most likely representative of helium-core white dwarfs, showing that these CVs are present in the overall population. We reveal the presence of an anti-correlation between the average accretion rates and the white dwarf masses for the systems below the 2 − 3 h period gap. Since ⟨M˙⟩ reflects the rate of system angular momentum loss, this correlation suggests the presence of an additional mechanism of angular momentum loss that is more efficient at low white dwarf masses. This is the fundamental concept of the recently proposed empirical prescription of consequential angular momentum loss (eCAML) and our results provide observational support for it, although we also highlight how its current recipe needs to be refined to better reproduce the observed scatter in Teff and ⟨M˙⟩⁠, and the presence of helium-core white dwarfs

Youth representations of environmental protest

A necessary condition for a functioning democracy is the participation of its citizens, including its youth. This is particularly true for political participation in environmental decisions because these decisions can have intergenerational consequences. In this article we examine young people’s beliefs about one form of political participation - protest - in the context of communities affected by fracking and associated anti-fracking protest, and discuss the implications of these representations for education. Drawing on focus groups with 121 young people (age 15-19) in 5 schools and colleges near sites which have experienced anti-fracking protest in England and Northern Ireland, we find young people well-informed about avenues for formal and non-formal political participation against a background of disillusionment with formal political processes and varying levels of support for protest. We find representations of protest as disruptive, divisive, extreme, less desirable than other forms of participation, and ineffective in bringing about change but effective in awareness-raising. These representations are challenging, not least because the way protest is interpreted is critical to the way people think and act in the world. These representations of environmental protest must be challenged through formal education in order to safeguard the UN Convention on the Rights of the Child and ensure that the spirit of Article 11 of the UK Human Rights Act is protected

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

In vitro diagnostic assays are effective during the acute phase of delayed-type drug hypersensitivity reactions

BackgroundPrevious reports have suggested that drug-specific lymphocyte proliferation assays (LPA) can be used retrospectively to confirm the culprit drug following delayed-type drug hypersensitivity reactions (DHR). However, only limited evidence supports their use in aiding acute clinical management. The aim of this study was to compare the LPA against combination cytokine assays for potential use in the acute setting.MethodsA total of 43 patients with DHR (19 during the acute reaction, 20 after recovery, four during acute and after recovery) and 14 control subjects without DHR were investigated using ex vivo analysis of drug-specific proliferation, and interferon (IFN)-? and interleukin (IL)-4 production.ResultsHealthy controls showed negative drug-specific proliferation and cytokine release in contrast to individuals with a known sensitivity (P &lt; 0·0001). The assays demonstrated a test specificity of 95% (LPA), 83% (IFN-?) and 92% (IL-4). The sensitivity of combined measurement of drug-specific IFN-? and IL-4 cytokines during acute DHR was better than LPA (82% vs. 50%), but all assays were less sensitive during the recovery phase. The correlation between LPA and IFN-? assays was strong (r = 0·7, P &lt; 0·0001), whereas the IL-4 assay did not correlate as well with either of these assays. In contrast to LPA, drug enzyme-linked immunosorbent spot assays showed positive responses in patients concurrently taking immunosuppressive medication.ConclusionsIn vitro assays of drug-specific IFN-? and IL-4 production offer potential for use as rapid diagnostic tests. Cytokine detection offers distinct advantages over the LPA, including a shorter assay time, a greater sensitivity and effectiveness in testing immunosuppressed patients

Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival

10.1042/BSR20170843Bioscience Reports374BSR20170843BRPT