Cardiogenic shock following administration of propofol and fentanyl in a healthy woman: a case report

<p>Abstract</p> <p>Introduction</p> <p>Cardiogenic shock is very uncommon in healthy people. The differential diagnosis for patients with acute heart failure in previously healthy hearts includes acute myocardial infarction and myocarditis. However, many drugs can also depress myocardial function. Propofol and fentanyl are frequently used during different medical procedures. The cardiovascular depressive effect of both drugs has been well established, but the development of cardiogenic shock is very rare when these agents are used.</p> <p>Case presentation</p> <p>After a minor surgical intervention, a 32-year-old Caucasian woman with no significant medical history went into sudden hemodynamic deterioration due to acute heart failure. An urgent echocardiogram showed severe biventricular dysfunction and an estimated left ventricular ejection fraction of 20%. Extracorporeal life support and mechanical ventilation were required. Five days later her ventricular function had fully recovered, which allowed the progressive withdrawal of medical treatment. Prior to her hospital discharge, cardiac MRI showed neither edema nor pathological deposits on the delayed contrast enhancement sequences. At her six-month follow-up examination, the patient was asymptomatic and did not require treatment.</p> <p>Conclusion</p> <p>Although there are many causes of cardiogenic shock, the presence of abrupt hemodynamic deterioration and the absence of a clear cause could be related to the use of propofol and fentanyl.</p

NIR fluorescent biotinylated cyanine dye: optical properties and combination with quantum dots as a potential sensing device

We present a water soluble and fluorescent biotinylated probe derived from a carbocyanine dye. A high efficiency of energy transfer was measured when the dyes were placed on the surface of streptavidin conjugated Quantum dots. The system is a model platform for potential application as a FRET-based fluorescent sensor.Fil: Menéndez, Guillermo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Pichel, María Eva. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; ArgentinaFil: Spagnuolo, Carla Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Jares, Elizabeth Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentin

Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery

<div><p>As a follow up to the antimycobacterial screening exercise and the release of GSK´s first Tres Cantos Antimycobacterial Set (TCAMS-TB), this paper presents the results of a second antitubercular screening effort of two hundred and fifty thousand compounds recently added to the GSK collection. The compounds were further prioritized based on not only antitubercular potency but also on physicochemical characteristics. The 50 most attractive compounds were then progressed for evaluation in three different predictive computational biology algorithms based on structural similarity or GSK historical biological assay data in order to determine their possible mechanisms of action. This effort has resulted in the identification of novel compounds and their hypothesized targets that will hopefully fuel future TB drug discovery and target validation programs alike.</p></div

Plot of calculated chromatographic logD_7.4 versus calculated molar refraction (CMR).

<p>All data were generated using the latest version of the GSK calculator. Grey crosses represent marketed drugs with >30% oral bioavailability, white crosses <30% oral bioavailability, and the two disclosed sets by black squares (the current 50 compounds) or black stars (the CMC2013 set of 177). The line represents a discriminator between likely good and bad permeability. The chromatographic logD scale gives values approximately two units higher than the traditional distribution values assessed in octanol/water.</p

HTS progression cascade leading to 50 confirmed H37Rv-positive compounds.

<p>HTS progression cascade leading to 50 confirmed H37Rv-positive compounds.</p

Complete biological profile of selected hit compounds and corresponding physico chemical properties.

<p>^a Mtb specific. *This compound has been evaluated against a clinical isolate of <i>M</i>.<i>tuberculosis</i> resistant to isoniazid and its MIC was in the range of H37Rv (1.6 uM). ^b Compounds being tested in the intracellular assay, data will be available from Dryad Digital Repository: <a href="http://dx.doi.org/10.5061/dryad.8r351" target="_blank">http://dx.doi.org/10.5061/dryad.8r351</a>.</p

Predicted KEGG pathways targeted by the GSK compounds.

<p>A) Venn diagram with common pathways from the three different approaches. B) Most under and over-represented pathways in our predictions. Panels A) and B) with the same representation as in Figure E in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0142293#pone.0142293.s001" target="_blank">S1 File</a>.</p

Significant links between compound families and targets.

<p>Significant links between compound families and targets.</p