26 research outputs found

    Memoria del segundo simposium sobre historia, sociedad y cultura de México y América Latina

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    La presente obra reúne 20 ponencias de las 27 que se presentaron en el “Segundo simposium sobre historia, sociedad y cultura de México y América Latina”, realizado el 8 y 9 de noviembre de 2006, en el Centro de Investigación en Ciencias Sociales y Humanidades (CICSyH) de la Universidad Autónoma del Estado de México (UAEM), en Toluca, Estado de México

    Modelado de las colas de la distribución de rendimientos del petróleo: Un análisis empírico fuera de la muestra

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    Este trabajo se deriva del un proyecto de investigación auspiciado por la SEP para el fortalecimiento de cuerpos académicos.Este artículo modela el comportamiento asintótico de las colas de distribución de rendimientos de la Mezcla de petróleo mexicana utilizando la teoría de valores extremos condicional. La evidencia empírica señala que las colas inferior y superior tiene diferente peso.Secretaría de Educación Pública

    Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects

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    ObjectiveObesity is associated with metabolic abnormalities, including insulin resistance and dyslipidemias. Previous studies demonstrated that genistein intake modifies the gut microbiota in mice by selectively increasing Akkermansia muciniphila, leading to reduction of metabolic endotoxemia and insulin sensitivity. However, it is not known whether the consumption of genistein in humans with obesity could modify the gut microbiota reducing the metabolic endotoxemia and insulin sensitivity.Research design and methods45 participants with a Homeostatic Model Assessment (HOMA) index greater than 2.5 and body mass indices of ≥30 and≤40 kg/m2 were studied. Patients were randomly distributed to consume (1) placebo treatment or (2) genistein capsules (50 mg/day) for 2 months. Blood samples were taken to evaluate glucose concentration, lipid profile and serum insulin. Insulin resistance was determined by means of the HOMA for insulin resistance (HOMA-IR) index and by an oral glucose tolerance test. After 2 months, the same variables were assessed including a serum metabolomic analysis, gut microbiota, and a skeletal muscle biopsy was obtained to study the gene expression of fatty acid oxidation.ResultsIn the present study, we show that the consumption of genistein for 2 months reduced insulin resistance in subjects with obesity, accompanied by a modification of the gut microbiota taxonomy, particularly by an increase in the Verrucomicrobia phylum. In addition, subjects showed a reduction in metabolic endotoxemia and an increase in 5′-adenosine monophosphate-activated protein kinase phosphorylation and expression of genes involved in fatty acid oxidation in skeletal muscle. As a result, there was an increase in circulating metabolites of β-oxidation and ω-oxidation, acyl-carnitines and ketone bodies.ConclusionsChange in the gut microbiota was accompanied by an improvement in insulin resistance and an increase in skeletal muscle fatty acid oxidation. Therefore, genistein could be used as a part of dietary strategies to control the abnormalities associated with obesity, particularly insulin resistance; however, long-term studies are needed

    Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study

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    none40siTo evaluate the discriminatory ability of ultrasound in calcium pyrophosphate deposition disease (CPPD), using microscopic analysis of menisci and knee hyaline cartilage (HC) as reference standard.Filippou, Georgios; Scanu, Anna; Adinolfi, Antonella; Toscano, Carmela; Gambera, Dario; Largo, Raquel; Naredo, Esperanza; Calvo, Emilio; Herrero-Beaumont, Gabriel; Zufferey, Pascal; Bonjour, Christel Madelaine; MacCarter, Daryl K; Makman, Stanley; Weber, Zachary; Figus, Fabiana; Möller, Ingrid; Gutierrez, Marwin; Pineda, Carlos; Clavijo Cornejo, Denise; Garcia, Hector; Ilizaliturri, Victor; Mendoza Torres, Jaime; Pichardo, Raul; Rodriguez Delgado, Luis Carlos; Filippucci, Emilio; Cipolletta, Edoardo; Serban, Teodora; Cirstoiu, Catalin; Vreju, Florentin Ananu; Grecu, Dan; Mouterde, Gaël; Govoni, Marcello; Punzi, Leonardo; Damjanov, Nemanja S; Keen, Helen Isobel; Bruyn, George Aw; Terslev, Lene; D'Agostino, Maria-Antonietta; Scirè, Carlo Alberto; Iagnocco, AnnamariaFilippou, Georgios; Scanu, Anna; Adinolfi, Antonella; Toscano, Carmela; Gambera, Dario; Largo, Raquel; Naredo, Esperanza; Calvo, Emilio; Herrero-Beaumont, Gabriel; Zufferey, Pascal; Bonjour, Christel Madelaine; Maccarter, Daryl K; Makman, Stanley; Weber, Zachary; Figus, Fabiana; Möller, Ingrid; Gutierrez, Marwin; Pineda, Carlos; Clavijo Cornejo, Denise; Garcia, Hector; Ilizaliturri, Victor; Mendoza Torres, Jaime; Pichardo, Raul; Rodriguez Delgado, Luis Carlos; Filippucci, Emilio; Cipolletta, Edoardo; Serban, Teodora; Cirstoiu, Catalin; Vreju, Florentin Ananu; Grecu, Dan; Mouterde, Gaël; Govoni, Marcello; Punzi, Leonardo; Damjanov, Nemanja S; Keen, Helen Isobel; Bruyn, George Aw; Terslev, Lene; D'Agostino, Maria-Antonietta; Scirè, Carlo Alberto; Iagnocco, Annamari
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