Towards a Systematic Approach for Smart Grid Hazard Analysis and Experiment Specification

The transition to the smart grid introduces complexity to the design and operation of electric power systems. This complexity has the potential to result in safety-related losses that are caused, for example, by unforeseen interactions between systems and cyber-attacks. Consequently, it is important to identify potential losses and their root causes, ideally during system design. This is non-trivial and requires a systematic approach. Furthermore, due to complexity, it may not possible to reason about the circumstances that could lead to a loss; in this case, experiments are required. In this work, we present how two complementary deductive approaches can be usefully integrated to address these concerns: Systems Theoretic Process Analysis (STPA) is a systems approach to identifying safety-related hazard scenarios; and the ERIGrid Holistic Test Description (HTD) provides a structured approach to refine and document experiments. The intention of combining these approaches is to enable a systematic approach to hazard analysis whose findings can be experimentally tested. We demonstrate the use of this approach with a reactive power voltage control case study for a low voltage distribution network.Comment: 2020 IEEE 18th International Conference on Industrial Informatics (INDIN

Clinical and genetic analysis of 29 Brazilian patients with Huntington’s disease-like phenotype

Huntington’s disease (HD) is a neurodegenerative disorder characterized by chorea, behavioral disturbances and dementia, caused by a pathological expansion of the CAG trinucleotide in the HTT gene. Several patients have been recognized with the typical HD phenotype without the expected mutation. The objective of this study was to assess the occurrence of diseases such as Huntington’s disease-like 2 (HDL2), spinocerebellar ataxia (SCA) 1, SCA2, SCA3, SCA7, dentatorubral-pallidoluysian atrophy (DRPLA) and choreaacanthocytosis (ChAc) among 29 Brazilian patients with a HD-like phenotype. In the group analyzed, we found 3 patients with HDL2 and 2 patients with ChAc. The diagnosis was not reached in 79.3% of the patients. HDL2 was the main cause of the HD-like phenotype in the group analyzed, and is attributable to the African ancestry of this population. However, the etiology of the disease remains undetermined in the majority of the HD negative patients with HD-like phenotype. Key words: Huntington’s disease, Huntington’s disease-like, chorea-acanthocytosis, Huntington’s disease-like 2

The economic impact of moderate stage Alzheimer's disease in Italy: Evidence from the UP-TECH randomized trial

Background: There is consensus that dementia is the most burdensome disease for modern societies. Few cost-of-illness studies examined the complexity of Alzheimer's disease (AD) burden, considering at the same time health and social care, cash allowances, informal care, and out-of-pocket expenditure by families. Methods: This is a comprehensive cost-of-illness study based on the baseline data from a randomized controlled trial (UP-TECH) enrolling 438 patients with moderate AD and their primary caregiver living in the community. Results: The societal burden of AD, composed of public, patient, and informal care costs, was about �20,000/yr. Out of this, the cost borne by the public sector was �4,534/yr. The main driver of public cost was the national cash-for-care allowance (�2,324/yr), followed by drug prescriptions (�1,402/yr). Out-of-pocket expenditure predominantly concerned the cost of private care workers. The value of informal care peaked at �13,590/yr. Socioeconomic factors do not influence AD public cost, but do affect the level of out-of-pocket expenditure. Conclusion: The burden of AD reflects the structure of Italian welfare. The families predominantly manage AD patients. The public expenditure is mostly for drugs and cash-for-care benefits. From a State perspective in the short term, the advantage of these care arrangements is clear, compared to the cost of residential care. However, if caregivers are not adequately supported, savings may be soon offset by higher risk of caregiver morbidity and mortality produced by high burden and stress. The study has been registered on the website www.clinicaltrials.org (Trial Registration number: NCT01700556). Copyright � International Psychogeriatric Association 2015

Socioeconomic Predictors of the Employment of Migrant Care Workers by Italian Families Assisting Older Alzheimer's Disease Patients: Evidence from the Up-Tech Study

Background: The availability of family caregivers of older people is decreasing in Italy as the number of migrant care workers (MCWs) hired by families increases. There is little evidence on the influence of socioeconomic factors in the employment of MCWs. Method: We analyzed baseline data from 438 older people with moderate Alzheimer's disease (AD), and their family caregivers enrolled in the Up-Tech trial. We used bivariate analysis and multilevel regressions to investigate the association between independent variables - education, social class, and the availability of a care allowance - and three outcomes - employment of a MCW, hours of care provided by the primary family caregiver, and by the family network (primary and other family caregivers). Results: The availability of a care allowance and the educational level were independently associated with employing MCWs. A significant interaction between education and care allowance was found, suggesting that more educated families are more likely to spend the care allowance to hire a MCW. Discussion: Socioeconomic inequalities negatively influenced access both to private care and to care allowance, leading disadvantaged families to directly provide more assistance to AD patients. Care allowance entitlement needs to be reformed in Italy and in countries with similar long-term care and migration systems. � 2015 The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved

Status and Trends of Physical Activity Surveillance, Policy, and Research in 164 Countries: Findings From the Global Observatory for Physical Activity—GoPA! 2015 and 2020 Surveys

Background: Physical activity (PA) surveillance, policy, and research efforts need to be periodically appraised to gain insight into national and global capacities for PA promotion. The aim of this paper was to assess the status and trends in PA surveillance, policy, and research in 164 countries. Methods: We used data from the Global Observatory for Physical Activity (GoPA!) 2015 and 2020 surveys. Comprehensive searches were performed for each country to determine the level of development of their PA surveillance, policy, and research, and the findings were verified by the GoPA! Country Contacts. Trends were analyzed based on the data available for both survey years. Results: The global 5-year progress in all 3 indicators was modest, with most countries either improving or staying at the same level. PA surveillance, policy, and research improved or remained at a high level in 48.1%, 40.6%, and 42.1% of the countries, respectively. PA surveillance, policy, and research scores decreased or remained at a low level in 8.3%, 15.8%, and 28.6% of the countries, respectively. The highest capacity for PA promotion was found in Europe, the lowest in Africa and low- and lower-middle-income countries. Although a large percentage of the world’s population benefit from at least some PA policy, surveillance, and research efforts in their countries, 49.6 million people are without PA surveillance, 629.4 million people are without PA policy, and 108.7 million live in countries without any PA research output. A total of 6.3 billion people or 88.2% of the world’s population live in countries where PA promotion capacity should be significantly improved. Conclusion: Despite PA is essential for health, there are large inequalities between countries and world regions in their capacity to promote PA. Coordinated efforts are needed to reduce the inequalities and improve the global capacity for PA promotion

Effect of polymorphism in the 5’ promoter region of the TG gene on the milk production traits of Polish Holstein-Friesian cattle

Celem podjętych badań było określenie zależności między występowaniem trzech różnych mutacji punktowych (257C>T, 335A>G, 422 C>T) w regionie promotorowym genu kodują- cego tyreoglobulinę (powodujących jego polimorfizm) a cechami użytkowości mlecznej by- dła. Badaniami objęto stado krów rasy polskiej holsztyńsko-fryzyjskiej. Ustalenie genotypów prowadzono z wykorzystaniem metody PCR i jej modyfikacji ACRS. Określono frekwencję częściej występujących alleli dla analizowanych mutacji punktowych: C ‒ 0,830 (257C>T), A ‒ 0,765 (335A>G) i C ‒ 0,635 (422C>T). Analiza statystyczna pokazała, że wszystkie trzy analizowane mutacje punktowe w regonie promotorowym genu TG istotnie (P≤0,05; P≤0,01) wpływają na analizowane cechy użytkowości mlecznej, tj. na dobową wydajność mleka, za- wartość tłuszczu i białka w mleku oraz liczbę komórek somatycznych

Towards a Systematic Approach for Smart Grid Hazard Analysis and Experiment Specification.

The transition to the smart grid introduces complexity to the design and operation of electric power systems. This complexity has the potential to result in safety-related losses that are caused, for example, by unforeseen interactions between systems and cyber-Attacks. Consequently, it is important to identify potential losses and their root causes, ideally during system design. This is non-Trivial and requires a systematic approach. Furthermore, due to complexity, it may not possible to reason about the circumstances that could lead to a loss; in this case, experiments are required. In this work, we present how two complementary deductive approaches can be usefully integrated to address these concerns: Systems Theoretic Process Analysis (STPA) is a systems approach to identifying safety-related hazard scenarios; and the ERIGrid Holistic Test Description (HTD) provides a structured approach to refine and document experiments. The intention of combining these approaches is to enable a systematic approach to hazard analysis whose findings can be experimentally tested. We demonstrate the use of this approach with a reactive power voltage control case study for a low voltage distribution network