Sound radiation and sound insulation performances of maritime bulkheads

The research of materials matching low weight and high resistance has always been a key factor in the shipbuilding industry to increase performances and loading capacity. Nowadays, other issues add up to economical convenience, and building quiet ships is important not only for passengers and cabin crew, but also to make harbor areas more comfortable and to respect the aquatic environment. In this context, using sandwich or composite materials must be carefully evaluated and the sound insulation performances must be considered throughout all stages of the design process. This work presents some evaluations about the sound insulation performances of a ribbed fiberglass bulkhead and of a balsa-core sandwich bulkhead. In particular, the bending stiffness and the sound transmission loss obtained by sound transmission suites and mobility measurements are provided. From such measurements it has also been possible to determine the radiation efficiency of the structures, whose optimization is particularly important when a reduction of the noise pollution is required

Acoustic quality of auditoria: Relationship between acoustical energy parameters and subjective perception

The acoustic design auditoria is founded on objective acoustic parameters determined on the basis of the computed or measured impulse response. Such objective parameters are related on the average response of the human ear to transient sounds, without considering the subjective perception of the individual, which, in turn, is related also to social and education aspects. The aim of this study is to investigate the relationship between individual sound perceptions and energy parameters. In detail, a questionnaire has been submitted to a sample of people listening to tracks of different musical genres. The questionnaire has been conceived to come up with a classification model for the audience allowing to express the listener's experience according to different indicators, such as overall acoustic quality and overall acoustic experience. Results of this experiment are analyzed by means of Random Forest non-parametric model belonging to the data mining algorithms. The final purpose of the study is to define which physical and acoustical characteristics are the most suitable to represent the subjective perceptions of the listeners

Fast electron slowing-down and diffusion in a high temperature coronal X-ray source

Finite thermal velocity modifications to electron slowing-down rates may be important for the deduction of solar flare total electron energy. Here we treat both slowing-down and velocity diffusion of electrons in the corona at flare temperatures, for the case of a simple, spatially homogeneous source. Including velocity diffusion yields a consistent treatment of both "accelerated" and "thermal" electrons. It also emphasises that one may not invoke finite thermal velocity target effects on electron lifetimes without simultaneously treating the contribution to the observed X-ray spectrum from thermal electrons. We present model calculations of the X-ray spectra resulting from injection of a power-law energy distribution of electrons into a source with finite temperature. Reducing the power-law distribution low-energy cutoff to lower and lower energies only increases the relative magnitude of the thermal component of the spectrum, because the lowest energy electrons simply join the background thermal distribution. Acceptable fits to RHESSI flare data are obtained using this model. These also demonstrate, however, that observed spectra may in consequence be acceptably consistent with rather a wide range of injected electron parameters

The sub-arcsecond hard X-ray structure of loop footpoints in a solar flare

The newly developed X-ray visibility forward fitting technique is applied to Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) data of a limb flare to investigate the energy and height dependence on sizes, shapes, and position of hard X-ray chromospheric footpoint sources. This provides information about the electron transport and chromospheric density structure. The spatial distribution of two footpoint X-ray sources is analyzed using PIXON, Maximum Entropy Method, CLEAN and visibility forward fit algorithms at nonthermal energies from $\sim 20$ to $\sim 200$ keV. We report, for the first time, the vertical extents and widths of hard X-ray chromospheric sources measured as a function of energy for a limb event. Our observations suggest that both the vertical and horizontal sizes of footpoints are decreasing with energy. Higher energy emission originates progressively deeper in the chromosphere consistent with downward flare accelerated streaming electrons. The ellipticity of the footpoints grows with energy from $\sim 0.5$ at $\sim 20$ keV to $\sim 0.9$ at $\sim 150$ keV. The positions of X-ray emission are in agreement with an exponential density profile of scale height $\sim 150$~km. The characteristic size of the hard X-ray footpoint source along the limb is decreasing with energy suggesting a converging magnetic field in the footpoint. The vertical sizes of X-ray sources are inconsistent with simple collisional transport in a single density scale height but can be explained using a multi-threaded density structure in the chromosphere.Comment: 7 pages, 7 figures, submitted to Ap

Brca detection rate in an italian cohort of luminal early-onset and triple-negative breast cancer patients without family history: When biology overcomes genealogy

NCCN Guidelines recommend BRCA genetic testing in individuals with a probability >5% of being a carrier. Nonetheless, the cost-effectiveness of testing individuals with no tumor family history is still debated, especially when BRCA testing is offered by the national health service. Our analysis evaluated the rate of BRCA pathogenic or likely-pathogenic variants in 159 triplenegative breast cancer (TNBC) patients diagnosed ≤60 years, and 109 luminal-like breast cancer (BC) patients diagnosed ≤35 without breast and/or ovarian family histories. In TNBC patients, BRCA mutation prevalence was 22.6% (21.4% BRCA1). Mutation prevalence was 64.2% ≤30 years, 31.8% in patients aged 31–40, 16.1% for those aged 41–50 and 7.9% in 51–60s. A total of 40% of patients with estrogen receptors (ER) 1–9% were BRCA1 carriers. BRCA detection rate in early-onset BCs was 6.4% (4.6% BRCA2). Mutation prevalence was 0% between 0–25 years, 9% between 26–30 years and 6% between 31–35 years. In conclusion, BRCA testing is recommended in TNBC patients diagnosed ≤60 years, regardless of family cancer history or histotype, and by using immunohistochemical staining <10% for both ER and/PR. In luminal-like early-onset BC, a lower BRCA detection rate was observed, suggesting a role for other predisposing genes along with BRCA genetic testing

Regularized energy-dependent solar flare hard x-ray spectral index

The deduction from solar flare X-ray photon spectroscopic data of the energy dependent model-independent spectral index is considered as an inverse problem. Using the well developed regularization approach we analyze the energy dependency of spectral index for a high resolution energy spectrum provided by Ramaty High Energy Solar Spectroscopic Imager (RHESSI). The regularization technique produces much smoother derivatives while avoiding additional errors typical of finite differences. It is shown that observations imply a spectral index varying significantly with energy, in a way that also varies with time as the flare progresses. The implications of these findings are discussed in the solar flare context.Comment: 13 pages; 5 figures, Solar Physics in pres

Immunohistochemical subtypes predict the clinical outcome in high-risk node-negative breast cancer patients treated with adjuvant FEC regimen: results of a single-center retrospective study

Prognostic factors for disease-free survival in patients treated before 2005 September: multivariate analysis. (DOCX 15 kb

Biomassa e atividade microbiana do solo sob diferentes coberturas vegetais em Região Cerrado - Mata Atlântica.

O estado de equilíbrio do ecossistema pode ser profundamente modificado pelo uso intensificado dos seus recursos, resultando alterações nos processos microbiológicos ocorridos no solo. Assim, o objetivo deste trabalho foi avaliar a qualidade do solo de diferentes áreas com base nos atributos microbiológicos. A avaliação foi realizada em cinco áreas no processo de restauração ecológica (REC1-5), uma área com vegetação nativa (MATA) e uma de cultivo de cana-de-açúcar (CN). Os atributos microbiológicos avaliados foram: Carbono da biomassa microbiana do solo (C-BMS), respiração basal (C-CO2), quociente microbiano (qMIC) e quociente metabólico (qCO2). O menor teor do parâmetro C-BMS foi observado na REC5, que diferenciou estatisticamente de REC2 e REC4. O fato de não haver distinção entre as RECs das áreas de CN e MATA sugere a influência, interação ou sinergismo entre fatores. A análise da matriz de similaridade por meio da distância euclidiana aplicada aos dados de atributos microbiológicos permitiu a distinção de CN em relação às demais formas de manejo do solo sendo, portanto, mais eficiente como ferramenta na caracterização do ambiente. Dentre as áreas em processo de restauração ecológica, REC2 e REC3 apresentaram condições microbiológicas com maior similaridade em relação à área de vegetação nativa (MATA), o que pode ser indicativo de melhoria na qualidade do solo e, consequentemente, aproximando-se do estado de equilíbrio da condição natural regional

Molecular Pathways of Breast Cancer in Systemic Sclerosis: Exploratory Immunohistochemical Analysis from the Sclero-Breast Study

Several authors reported an increased risk of cancer in SSc patients, including breast cancer (BC). Nevertheless, the mechanisms underlying this association have not yet been clarified. SSc and BC share several molecular pathways, which seem to play a common etiopathogenetic role. The previously published Sclero-Breast study demonstrated the development of BC with a good prognosis among these patients, which could be explained by an autoimmune background as a possible mechanism for limiting tumor extension. Here, we report the results of an IHC analysis of molecular pathways known to be common drivers for both diseases, with the aim to better define the mechanisms underlying a good prognosis of BC in patients affected by SSc. The analysis demonstrated higher TILs rates in all BC subgroups, with a high rate of PD-L1 expression especially in TNBC and HER2-positive BC, suggesting a less aggressive behavior in these patients compared to the general population. These results support a possible de-escalation strategy of cancer therapies in these fragile patients. These data could represent a starting point for future prospective studies based on the clinical application of these biomarkers with a larger sample size to promote a personalized and targeted oncological treatment for this specific subset of patients