‘Everyone thought I was a very very bad person… no one want to know you like the nurses and doctors’:using focus groups to elicit the views of adults with learning disability who use challenging behaviour services

and Tables S1–S3. (PDF 3090 kb

An epigenetic clock for gestational age at birth based on blood methylation data

Background: Gestational age is often used as a proxy for developmental maturity by clinicians and researchers alike. DNA methylation has previously been shown to be associated with age and has been used to accurately estimate chronological age in children and adults. In the current study, we examine whether DNA methylation in cord blood can be used to estimate gestational age at birth. Results: We find that gestational age can be accurately estimated from DNA methylation of neonatal cord blood and blood spot samples. We calculate a DNA methylation gestational age using 148 CpG sites selected through elastic net regression in six training datasets. We evaluate predictive accuracy in nine testing datasets and find that the accuracy of the DNA methylation gestational age is consistent with that of gestational age estimates based on established methods, such as ultrasound. We also find that an increased DNA methylation gestational age relative to clinical gestational age is associated with birthweight independent of gestational age, sex, and ancestry. Conclusions: DNA methylation can be used to accurately estimate gestational age at or near birth and may provide additional information relevant to developmental stage. Further studies of this predictor are warranted to determine its utility in clinical settings and for research purposes. When clinical estimates are available this measure may increase accuracy in the testing of hypotheses related to developmental age and other early life circumstances.Peer reviewe

Characteristics of the participants of the Predo-Study.

<p>Characteristics of the participants of the Predo-Study.</p

Maternal Prenatal Positive Affect, Depressive and Anxiety Symptoms and Birth Outcomes: The PREDO Study - Fig 1

<p>Trajectories of maternal (A) positive affect (PANAS), (B) depressive symptoms (CES-D), and (C) anxiety symptoms (STAI) at two-week intervals according to preterm (≤ 36 6/7 gestational weeks), term (37 0/7-41 6/7 gestational weeks) and post-term delivery (≥ 42 0/7 gestational weeks).</p

The associations between prenatal positive affect, depressive and anxiety symptoms with birth outcome.

<p>The associations between prenatal positive affect, depressive and anxiety symptoms with birth outcome.</p

Additional file 1: of Prediction of pre-eclampsia and its subtypes in high-risk cohort: hyperglycosylated human chorionic gonadotropin in multivariate models

Table S1. Inclusion and exclusion criteria of the risk group. The inclusion and exlusion criteria for the risk group in PREDO project. (DOCX 67 kb

Additional file 2: of Prediction of pre-eclampsia and its subtypes in high-risk cohort: hyperglycosylated human chorionic gonadotropin in multivariate models

Table S2. The number of each inclusion criterion in women with and without pre-eclampsia. (DOCX 77 kb

Additional file 3: of Prediction of pre-eclampsia and its subtypes in high-risk cohort: hyperglycosylated human chorionic gonadotropin in multivariate models

Table S3. Concentrations of biomarkers, mean arterial pressure and uterine artery pulsatility index. The median concentrations of each biomarker, mean arterial pressure and uterine artery pulsatility index in women with and without pre-eclampsia and by pre-eclampsia subtype. (DOCX 78 kb