The Journey From Drug Addiction to Drug Withdrawal: A Christian Gospel Rehabilitation Program in Taiwan

Background World Drug Report estimates the number of opioid users at 53 million and identifies opioids as responsible for two thirds of the 585,000 people who died as a result of drug use in 2017. Purpose The purpose of this study was to analyze the testimonies of 30 people regarding their journeys from drug addiction to drug withdrawal in Taiwan. Methods This was a qualitative research design. The sample inclusion criteria were as follows: (a) being a drug abuser, (b) completed the Christian Gospel Drug Withdrawal Program or church-sponsored program, and (c) shared their related testimony on the Good TV television channel in Taiwan. The participants\u27 stories were posted in Chinese, transcribed by the author, and translated from Chinese into English. Content analysis was used to identify the major themes. Results Of the 30 participants, 24 were male (80%) and six were female (20%). The major themes identified in their testimonies were: (a) Using illegal drugs related to peer recognition, lack of knowledge, and temptations; (b) drug addiction was an endless pain cycle; (c) turning points related to love, repentance, and hope; (d) drug withdrawal was related to avoiding temptation and overcoming the drug withdrawal syndrome through the Holy Spirit; and (e) outcomes were faith and new life. Conclusions/Implications for Practice In this study, people who received the gospel drug withdrawal programs expressed that their lives had changed, they had withdrawn from drugs successfully, they had become volunteers to help others, and interactions with their family had improved. These programs may be applied in the mental health nursing profession

Human Resource Development for Health in Indonesia: Challenges of Achieving the Millennium Development Goals

Background The development of Human Resources for Health (HRH) is one of the keys to achieving The Millennium Development Goals (MDG). Providing and ensuring the best health care service in every region of Indonesia has long been a major concern. Several challenges faced by HRH development are a shortage of professionals, uneven distribution of professionals between regions, a variety of settings (urban and rural), and management of the health workforce under a decentralization system. Aim This paper aims to assess the HRH progress made toward achieving the health-related MDGs. Methods A desk study was performed from relevant published materials. Literature was reviewed from databases of the Ministry of Health. A clear understanding of the progress and challenges is critical to accelerating the achievement of MDGs. Results The health policy of Indonesia has been adjusted to achieve MDGs. A significant scale‐up in the HRH can contribute to significant number to meet the MDGs. HRH dimensions that must be addressed include comprehensive HRH strategies and strengthening management under decentralization system. Conclusion Human resources are one of supporting unit in achieving Millennium Development Goals. Therefore, it is important to identify where we stand and mobilize more resources to meet the off track in MDGs

Elevated expression of L-selectin ligand in lymph node-derived human prostate cancer cells correlates with increased tumorigenicity.

Human prostate cancer LNCaP cells including C-33 and C-81 cells were originally derived from the lymph nodes of a patient with metastatic prostate cancer. These two cells were employed for characterization of L-selectin ligand and in vitro tumorigenicity, because they mimic the clinical conditions of early and late-stage human prostate cancer. C-81 cells exhibit higher in vitro migratory and invasive properties as compared with C-33 cells. We find that the L-selectin ligand and mucin glycan-associated MECA-79 epitope were elevated in C-81 cells. An increase of these glycotopes positively correlates with elevated tumorigenicity and expression of key glycosyl- and sulfotransferase genes. These results suggest that modulated expression of selective glycogenes correlates with altered tumorigenicity of cancer cells

Surgical Management of Traumatic Facial Paralysis: A Case Review Study

AbstractObjectiveTo evaluate efficacy of surgical treatment in traumatic facial paralysis.MethodsThirty–three cases were reviewed, including temporal bone fracture and iatrogenic facial nerve injury. All the patients were treated with various surgical methods according to their pathogeny.ResultsThe mean percentage facial function improvement (House–Brackmann Grade I – II) was 86% in temporal bone fracture and function was improved after proper operation to iatrogenic facial nerve injury.ConclusionsPatients with traumatic facial paralysis receive proved outcomes itreaed with proper surgical methods according to their particular condition of nerve injury

Prediction Markets: A Systematic Review and Meta-Analysis

Prediction markets (PM) have drawn considerable attention in recent years as a tool for forecasting events. Studies surveying and examining relevant the trends of PM using traditional approaches have been reported in the literature. However, research using meta-analysis to review Prediction markets systems is very limited in Management Information System (MIS). This paper aimed to fill this gap by using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method to study Prediction markets trends over the past decades. Our results are as follows. First, we find that shows that more than 64% of academic studies on Prediction markets are published in top journals such as Journal of the Association for Information Systems, Journal of Consumer Research and Information Systems Research. Second, we showed that Prediction markets applications can be can be divided into two groups: internal use PMS and general public usage. Finally, our significant meta-analysis result show that on average prediction markets is 79% more accurate than alternative forecast methods based

Human Resource Development for Health in Indonesia: Challenges of Achieving the Millennium Development Goals

The development of Human Resources for Health (HRH) is one of the keys to achieving The Millennium Development Goals (MDG). Providing and ensuring the best health care service in every region of Indonesia has long been a major concern. Several challenges faced by HRH development are a shortage of professionals, uneven distribution of professionals between regions, a variety of settings (urban and rural), and management of the health workforce under a decentralization system

GmPHD5 acts as an important regulator for crosstalk between histone H3K4 di-methylation and H3K14 acetylation in response to salinity stress in soybean

<p>Abstract</p> <p>Background</p> <p>Accumulated evidence suggest that specific patterns of histone posttranslational modifications (PTMs) and their crosstalks may determine transcriptional outcomes. However, the regulatory mechanisms of these "histone codes" in plants remain largely unknown.</p> <p>Results</p> <p>In this study, we demonstrate for the first time that a salinity stress inducible PHD (plant homeodomain) finger domain containing protein GmPHD5 can read the "histone code" underlying the methylated H3K4. GmPHD5 interacts with other DNA binding proteins, including GmGNAT1 (an acetyl transferase), GmElongin A (a transcription elongation factor) and GmISWI (a chromatin remodeling protein). Our results suggest that GmPHD5 can recognize specific histone methylated H3K4, with preference to di-methylated H3K4. Here, we illustrate that the interaction between GmPHD5 and GmGNAT1 is regulated by the self-acetylation of GmGNAT1, which can also acetylate histone H3. GmGNAT1 exhibits a preference toward acetylated histone H3K14. These results suggest a histone crosstalk between methylated H3K4 and acetylated H3K14. Consistent to its putative roles in gene regulation under salinity stress, we showed that GmPHD5 can bind to the promoters of some confirmed salinity inducible genes in soybean.</p> <p>Conclusion</p> <p>Here, we propose a model suggesting that the nuclear protein GmPHD5 is capable of regulating the crosstalk between histone methylation and histone acetylation of different lysine residues. Nevertheless, GmPHD5 could also recruit chromatin remodeling factors and transcription factors of salt stress inducible genes to regulate their expression in response to salinity stress.</p