Identification of Faint Chandra X-ray Sources in the Core-Collapsed Globular Cluster NGC 6752

We have searched for optical identifications for 39 Chandra X-ray sources that lie within the 1.9 arcmin half-mass radius of the nearby (d = 4.0 kpc), core-collapsed globular cluster, NGC 6752, using deep Hubble Space Telescope ACS/WFC imaging in B435, R625, and H alpha. Photometry of these images allows us to classify candidate counterparts based primarily on color-magnitude and color-color diagram location. The color-color diagram is particularly useful for quantifying the H alpha line equivalent width. In addition to recovering 11 previously detected optical counterparts, we propose 20 new optical IDs. In total, there are 16 likely or less certain cataclysmic variables (CVs), nine likely or less certain chromospherically active binaries, three galaxies, and three active galactic nuclei (AGNs). The latter three sources, which had been identified as likely CVs by previous investigations, now appear to be extragalactic objects based on their proper motions. As we previously found for NGC 6397, the CV candidates in NGC 6752 fall into a bright group that is centrally concentrated relative to the turnoff-mass stars and a faint group that has a spatial distribution that is more similar to that of the turnoff-mass stars. This is consistent with an evolutionary scenario in which CVs are produced by dynamical interactions near the cluster center and diffuse to larger radius orbits as they age.Comment: 26 pages, 18 figure

Identification Of Faint Chandra X-Ray Sources In The Core-Collapsed Globular Cluster NGC 6397: Evidence For A Bimodal Cataclysmic Variable Population

We have searched for optical identifications for 79 Chandra X-ray sources that lie within the half-mass radius of the nearby, core-collapsed globular cluster NGC 6397, using deep Hubble Space Telescope Advanced Camera for Surveys Wide Field Channel imaging in H alpha, R, and B. Photometry of these images allows us to classify candidate counterparts based on color-magnitude diagram location. In addition to recovering nine previously detected cataclysmic variables (CVs), we have identified six additional faint CV candidates, a total of 42 active binaries (ABs), two millisecond pulsars, one candidate active galactic nucleus, and one candidate interacting galaxy pair. Of the 79 sources, 69 have a plausible optical counterpart. The 15 likely and possible CVs in NGC 6397 mostly fall into two groups: a brighter group of six for which the optical emission is dominated by contributions from the secondary and accretion disk and a fainter group of seven for which the white dwarf dominates the optical emission. There are two possible transitional objects that lie between these groups. The faintest CVs likely lie near the minimum of the CV period distribution, where an accumulation is expected. The spatial distribution of the brighter CVs is much more centrally concentrated than those of the fainter CVs and the ABs. This may represent the result of an evolutionary process in which CVs are produced by dynamical interactions, such as exchange reactions, near the cluster center and are scattered to larger orbital radii, over their lifetimes, as they age and become fainter.NASA HST-GO-10257ANSF REU AST-0452975NSERCCIFARAstronom

Exotica in the Globular Cluster M4, Studied with Chandra, HST, and the VLA

Using the Hubble Ultraviolet Globular Cluster Survey (HUGS) and additional HST archival data, we have carried out a search for optical counterparts to the low-luminosity Chandra X-ray sources in the globular cluster M4 (NGC 6121). We have also searched for optical or X-ray counterparts to radio sources detected by the VLA. We find 24 new confident optical counterparts to Chandra sources for a total of 40, including the 16 previously identified. Of the 24 new identifications, 18 are stellar coronal X-ray sources (active binaries, ABs), the majority located along the binary sequence in a V-I colour-magnitude diagram and generally showing an H-alpha excess. In addition to confirming the previously detected cataclysmic variable (CV, CX4), we identify one confident new CV (CX76), and two candidates (CX81 and CX101). One MSP is known in M4 (CX12), and another strong candidate has been suggested (CX1); we identify some possible MSP candidates among optical and radio sources, such as VLA20, which appears to have a white dwarf counterpart. One X-ray source with a sub-subgiant optical counterpart and a flat radio spectrum (CX8, VLA31) is particularly mysterious. The radial distribution of X-ray sources suggests a relaxed population of average mass ~ 1.2 - 1.5 Msun. Comparing the numbers of ABs, MSPs, and CVs in M4 with other clusters indicates that AB numbers are proportional to cluster mass (primordial population), MSPs to stellar encounter rate (dynamically formed population), while CVs seem to be produced both primordially and dynamically.Comment: 30 pages, 12 figures, 2 pages of supplementary material containing finding chart

Gemfibrozil Inhibits Legionella pneumophila and Mycobacterium tuberculosis Enoyl Coenzyme A Reductases and Blocks Intracellular Growth of These Bacteria in Macrophages

We report here that gemfibrozil (GFZ) inhibits axenic and intracellular growth of Legionella pneumophila and of 27 strains of wild-type and multidrug-resistant Mycobacterium tuberculosis in bacteriological medium and in human and mouse macrophages, respectively. At a concentration of 0.4 mM, GFZ completely inhibited L. pneumophila fatty acid synthesis, while at 0.12 mM it promoted cytoplasmic accumulation of polyhydroxybutyrate. To assess the mechanism(s) of these effects, we cloned an L. pneumophila FabI enoyl reductase homolog that complemented for growth an Escherichia coli strain carrying a temperature-sensitive enoyl reductase and rendered the complemented E. coli strain sensitive to GFZ at the nonpermissive temperature. GFZ noncompetitively inhibited this L. pneumophila FabI homolog, as well as M. tuberculosis InhA and E. coli FabI

Even free radicals should follow some rules: a guide to free radical research terminology and methodology.

Free radicals and oxidants are now implicated in physiological responses and in several diseases. Given the wide range of expertise of free radical researchers, application of the greater understanding of chemistry has not been uniformly applied to biological studies. We suggest that some widely used methodologies and terminologies hamper progress and need to be addressed. We make the case for abandonment and judicious use of several methods and terms and suggest practical and viable alternatives. These changes are suggested in four areas: use of fluorescent dyes to identify and quantify reactive species, methods for measurement of lipid peroxidation in complex biological systems, claims of antioxidants as radical scavengers, and use of the terms for reactive species

Sleep During Pregnancy: The nuMoM2b Pregnancy and Sleep Duration and Continuity Study

Study Objectives: To characterize sleep duration, timing and continuity measures in pregnancy and their association with key demographic variables. Methods: Multisite prospective cohort study. Women enrolled in the nuMoM2b study (nulliparous women with a singleton gestation) were recruited at the second study visit (16-21 weeks of gestation) to participate in the Sleep Duration and Continuity substudy. Women <18 years of age or with pregestational diabetes or chronic hypertension were excluded from participation. Women wore a wrist activity monitor and completed a sleep log for 7 consecutive days. Time in bed, sleep duration, fragmentation index, sleep efficiency, wake after sleep onset, and sleep midpoint were averaged across valid primary sleep periods for each participant. Results: Valid data were available from 782 women with mean age of 27.3 (5.5) years. Median sleep duration was 7.4 hours. Approximately 27.9% of women had a sleep duration of 9 hours. In multivariable models including age, race/ethnicity, body mass index, insurance status, and recent smoking history, sleep duration was significantly associated with race/ethnicity and insurance status, while time in bed was only associated with insurance status. Sleep continuity measures and sleep midpoint were significantly associated with all covariates in the model, with the exception of age for fragmentation index and smoking for wake after sleep onset. Conclusions: Our results demonstrate the relationship between sleep and important demographic characteristics during pregnancy

Testing the Solar Probe Cup, an Instrument Designed to Touch the Sun

Solar Probe Plus will be the first, fastest, and closest mission to the sun, providing the first direct sampling of the sub-Alfvenic corona. The Solar Probe Cup (SPC) is a unique re-imagining of the traditional Faraday Cup design and materials for immersion in this high temperature environment. Sending an instrument of this type into a never-seen particle environment requires extensive characterization prior to launch to establish sufficient measurement accuracy and instrument response. To reach this end, a slew of tests for allowing SPC to see ranges of appropriate ions and electrons, as well as a facility that reproduces solar photon spectra and fluxes for this mission. Having already tested the SPC at flight like temperatures with no significant modification of the noise floor, we recently completed a round of particle testing to see if the deviations in Faraday Cup design fundamentally change the operation of the instrument. Results and implications from these tests will be presented, as well as performance comparisons to cousin instruments such as those on the WIND spacecraft