Building the Nation through Women's Health: Modern Midwifery in Early Twentieth-Century China

China's nation-building agenda in the early twentieth century embraced the causes of women's rights and medical modernization. Modernizers considered the poor health of the Chinese population to be a major impediment to progress. Specifically, modern midwifery would improve the health of the nation at its most fundamental level, both by lowering the high infant mortality rate and by securing the well-being of future generations. Amid growing interest in maternal and child health, women entered the Western medical profession as midwives, nurses, and obstetrician/gynecologists. Local and national governments in China supported midwife training and research for the health of future generations. China's central government established a National Midwifery Board in 1929 to create and oversee training programs and enact laws to regulate modern midwives and physicians. Medical professionals and associations had enough political clout to transform public health policy. They successfully lobbied for legislation and actively advocated adopting aspects of Western medicine for women.Midwives engendered better and stronger generations by using new methods and equipment. Furthermore, midwife training allowed Chinese women to participate in modernization by joining the labor force, thus challenging traditional Chinese notions of female passivity and seclusion. At the same time, however, these modern midwives displaced the traditional old-style "birth grannies" who had served as social and ritual mediators within the family and community. This research examines midwifery and childbirth technologies introduced into China in the early twentieth century in relation to nation building, modernization, and changing gender ideologies. By using biographical data, legislation, and articles in the popular press, among other sources, I explore the changing notions of gender propriety that prompted Chinese women to utilize Western-trained midwives, read literature dealing with such intimate matters as childbirth and prenatal training, give birth in hospitals or maternity clinics, and enter the medical profession as midwives

Le consentement à la recherche en pharmacogénomique

[À l'origine dans / Was originally part of : CRDP - Droit, biotechnologie et rapport au milieu]Cet article analyse les pratiques éthiques et légales en matière de consentement éclairé dans le domaine de la recherche en pharmacogénomique. Les auteurs y examinent la manière dont les politiques internationales, régionales et nationales répondent aux nouveaux enjeux éthiques suscités par la pharmacogénomique. Ils concluent que le cadre éthique servant à guider les chercheurs dans ce domaine est encore en développement et nécessite un approfondissement pour répondre aux enjeux soulevés par cette importante discipli

Consent in Pharmacogenomic research

[À l'origine dans / Was originally part of : CRDP - Droit, biotechnologie et rapport au milieu]This article analyzes the emerging ethical and legal requirements for informed consent in pharmacogenomic research. It reviews how policies at the international, regional and national levels have responded to the ethical challenges raised by this new research area. It concludes that the pharmacogenomic policy framework is still in its infancy and needs to be further developed to answer the challenges raised by this important discipline

Selecting, Adapting, and Implementing Evidence-based Interventions in Rural settings: An Analysis of 70 community examples

Objective. This paper explores how communities translate evidence- based and promising health practices to rural contexts. Methods. A descriptive, qualitative analysis was conducted using data from 70 grantees funded by the Federal Office of Rural Health Policy to implement evidence- based health practices in rural settings. Findings were orga-nized using The Interactive Systems Framework for Dissemination and Implementation. Results. Grantees broadly interpreted evidence- based and promising practices, resulting in the implementation of a patchwork of health- related interventions that fell along a spectrum of evidentiary rigor. The cohort faced common challenges translating recognized practices into rural community settings and reported making deliberate modifications to original models as a result. Conclusion. Opportunities for building a more robust rural health evidence base include investments to incentivize evidence- based programming in rural settings; rural- specific research and theory- building; translation of existing evidence using a rural lens; technical assistance to support rural innovation; and prioritization of evaluation locally

A Framework for Articulating and Measuring Individual Learning Outcomes from Participation in Citizen Science

Since first being introduced in the mid 1990s, the term “citizen science”—the intentional engagement of the public in scientific research—has seen phenomenal growth as measured by the number of projects developed, people involved, and articles published. In addition to contributing to scientific knowledge, many citizen science projects attempt to achieve learning outcomes among their participants, however, little guidance is available for practitioners regarding the types of learning that can be supported through citizen science or the measuring of learning outcomes. This study provides empirical data to understand how intended learning outcomes first described by the informal science education field have been employed and measured within the citizen science field. We also present a framework for describing learning outcomes that should help citizen science practitioners, researchers, and evaluators in designing projects and in studying and evaluating their impacts. This is a first step in building evaluation capacity across the field of citizen science

Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA

Helicobacter pylori is a leading cause of peptic ulceration and gastric cancer worldwide. To achieve colonization of the stomach, this Gram-negative bacterium adheres to Lewis(b) (Le(b)) antigens in the gastric mucosa using its outer membrane protein BabA. Structural information for BabA has been elusive, and thus, its molecular mechanism for recognizing Le(b) antigens remains unknown. We present the crystal structure of the extracellular domain of BabA, from H. pylori strain J99, in the absence and presence of Le(b) at 2.0- and 2.1-Å resolutions, respectively. BabA is a predominantly α-helical molecule with a markedly kinked tertiary structure containing a single, shallow Le(b) binding site at its tip within a β-strand motif. No conformational change occurs in BabA upon binding of Le(b), which is characterized by low affinity under acidic [K D (dissociation constant) of ~227 μM] and neutral (K D of ~252 μM) conditions. Binding is mediated by a network of hydrogen bonds between Le(b) Fuc1, GlcNAc3, Fuc4, and Gal5 residues and a total of eight BabA amino acids (C189, G191, N194, N206, D233, S234, S244, and T246) through both carbonyl backbone and side-chain interactions. The structural model was validated through the generation of two BabA variants containing N206A and combined D233A/S244A substitutions, which result in a reduction and complete loss of binding affinity to Le(b), respectively. Knowledge of the molecular basis of Le(b) recognition by BabA provides a platform for the development of therapeutics targeted at inhibiting H. pylori adherence to the gastric mucosa

In Situ Template Generation for Zincophosphate Synthesis Leading to C2H7N4O-ZnPO4 Containing Template-to-Template N--H...O Hydrogen Bonds

The synthesis, structure and some properties of C{sub 2}H{sub 7}N{sub 4}O {center_dot} ZnPO{sub 4} (guanylurea zinc phosphate) are reported. The cationic template was prepared in situ by partial hydrolysis of the neutral 2-cyanoguanidine starting material. The resulting structure contains a new, unprotonated, zincophosphate layer topology as well as unusual N-H-O template-to-template hydrogen bonds which help to stabilize a ''double sandwich'' of templating cations between the inorganic sheets. Crystal data: C{sub 2}H{sub 7}N{sub 4}O {center_dot} ZnPO{sub 4}, M{sub r} = 229.44, monoclinic, P2{sub 1}/c, a = 13.6453 (9) {angstrom}, b = 5.0716 (3) {angstrom}, c = 10.6005 (7) {angstrom}, {beta} = 95.918 (2){sup 0}, V = 729.7 (1) {angstrom}{sup 3}, R(F) = 0.034, wR(F) = 0.034

Public Participation in Scientific Research: a Framework for Deliberate Design

Members of the public participate in scientific research in many different contexts, stemming from traditions as varied as participatory action research and citizen science. Particularly in conservation and natural resource management contexts, where research often addresses complex social–ecological questions, the emphasis on and nature of this participation can significantly affect both the way that projects are designed and the outcomes that projects achieve. We review and integrate recent work in these and other fields, which has converged such that we propose the term public participation in scientific research (PPSR) to discuss initiatives from diverse fields and traditions. We describe three predominant models of PPSR and call upon case studies suggesting that—regardless of the research context—project outcomes are influenced by (1) the degree of public participation in the research process and (2) the quality of public participation as negotiated during project design. To illustrate relationships between the quality of participation and outcomes, we offer a framework that considers how scientific and public interests are negotiated for project design toward multiple, integrated goals. We suggest that this framework and models, used in tandem, can support deliberate design of PPSR efforts that will enhance their outcomes for scientific research, individual participants, and social–ecological systems