Individual Differences in Comparison Question Anxiety

"The comparison question polygraph test (CQT) is a well-known technique for the detection of deception in legal and criminal settings (Raskin et al., 1989). According to Raskin and colleagues, the CQT was developed to address the limitations of the relevant-irrelevant (R-I) test, which uses only two types of questions, relevant and neutral. In the R-I test, neutral questions do not have any salience (i.e. are not relevant) for the innocent examinee. In this sense, they function as a ttcontrol" condition."(...

Towards a novel carbon device for the treatment of sepsis

Sepsis is a systemic inflammatory response to infection in which the balance of pro- andanti-inflammatory mediators, which normally isolate and eliminate infection, is disrupted[1]. Gram negative sepsis is initiated by bacterial endotoxin release which activatesmacrophages and circulating monocytes to release TNF and IL-1β followed by IL-6 andother inflammatory cytokines [2]. As the disease progresses, an unregulatedinflammatory response results in, tissue injury, haematological dysfunction and organdysfunction. Severe sepsis, involving organ hypoperfusion may be further complicatedby hypotension that is unresponsive to adequate fluid replacement, resulting in septicshock and finally death [3].Despite improvements in anti-microbial and supportive therapies, sepsis remains asignificant cause of morbidity and mortality in ICUs worldwide [4]. The complexity ofprocesses mediating the progression of sepsis suggests that an extracorporeal devicecombining blood filtration with adsorption of a wide range of toxins, and inflammatorymediators offers the most comprehensive treatment strategy. However, no such deviceexists at present. A novel, uncoated, polymer pyrolysed synthetic carbon device isproposed which combines the superior adsorption properties of uncoated activatedcarbons with the capacity to manipulate porous structure for controlled adsorption oftarget plasma proteins and polypeptides [5]. Preliminary haemocompatibility andadsorptive capacity was assessed using a carbon matrix prototype

Compounding Impacts of Human-Induced Water Stress and Climate Change on Water Availability

The terrestrial phase of the water cycle can be seriously impacted by water management and human water use behavior (e.g., reservoir operation, and irrigation withdrawals). Here we outline a method for assessing water availability in a changing climate, while explicitly considering anthropogenic water demand scenarios and water supply infrastructure designed to cope with climatic extremes. The framework brings a top-down and bottom-up approach to provide localized water assessment based on local water supply infrastructure and projected water demands. When our framework is applied to southeastern Australia we find that, for some combinations of climatic change and water demand, the region could experience water stress similar or worse than the epic Millennium Drought. We show considering only the influence of future climate on water supply, and neglecting future changes in water demand and water storage augmentation might lead to opposing perspectives on future water availability. While human water use can significantly exacerbate climate change impacts on water availability, if managed well, it allows societies to react and adapt to a changing climate. The methodology we present offers a unique avenue for linking climatic and hydrologic processes to water resource supply and demand management and other human interactions

Formate Over-Oxidation Limits Industrialization of Glycerol Oxidation Paired with Carbon Dioxide Reduction to Formate

Electrocatalytic CO2 reduction processes are generally coupled with the oxidation of water. Process economics can greatly improve by replacing the water oxidation with a more valuable oxidation reaction, a process called paired electrolysis. Here we report the feasibility of pairing CO2 reduction with the oxidation of glycerol on Ni3S2/NF anodes to produce formate at both anode and cathode. Initially we optimized the oxidation of glycerol to maximize the Faraday efficiency to formate by using design of experiments. In flow cell electrolysis, excellent selectivity (up to 90 % Faraday efficiency) was achieved at high current density (150 mA/cm2 of geometric surface area). Then we successfully paired the reduction of CO2 with the oxidation of glycerol. A prerequisite for industrial application is to obtain reaction mixtures with a high concentration of formate to enable efficient downstream separation. We show that the anodic process is limited in formate concentration, as Faraday efficiency to formate greatly decreases when operating at 2.5 M formate (∼10 w%) in the reaction mixture due to over-oxidation of formate. We identify this as a major bottleneck for the industrial feasibility of this paired electrolysis process.</p

Deconstructing 1S0 nucleon-nucleon scattering

A distorted-wave method is used to analyse nucleon-nucleon scattering in the 1S0 channel. Effects of one-pion exchange are removed from the empirical phase shift to all orders by using a modified effective-range expansion. Two-pion exchange is then subtracted in the distorted-wave Born approximation, with matrix elements taken between scattering waves for the one-pion exchange potential. The residual short-range interaction shows a very rapid energy dependence for kinetic energies above about 100 MeV, suggesting that the breakdown scale of the corresponding effective theory is only 270MeV. This may signal the need to include the Delta resonance as an explicit degree of freedom in order to describe scattering at these energies. An alternative strategy of keeping the cutoff finite to reduce large, but finite, contributions from the long-range forces is also discussed.Comment: 10 pages, 2 figures (introduction revised, references added; version to appear in EPJA

New insight into the prevalence and risk factors for three distinct hoof conformation traits in UK commercial sheep flocks

Lameness in sheep continues to be a global health, welfare and economic concern. Damaged, misshapen or overgrown feet have the potential to cause lameness either directly, or indirectly. There is a lack of understanding of the predisposing factors for different hoof conformation traits in sheep. Our exploratory study aimed to investigate the prevalence of, and risk factors for, three distinct hoof conformation traits relating to the sole and heel, hoof wall, and hoof wall overgrowth. Feet of 400 ewes from four UK commercial sheep farms were inspected at four time points across 12 months. For each conformation trait, a four-point ordinal system was used to score each individual claw, and foot-level scores were calculated. We present 92.4% of foot-level observations to be affected by ≥1 conformation traits. Whilst hoof conformation traits were correlated to some degree, a unique set of sheep-, foot- and farm-level factors were associated with each distinct conformation trait. We provide, for the first time, key insight into the multifaceted and multifactorial aetiology of hoof conformation in sheep, building upon previous landmark studies. Our results inform hypotheses for future prospective studies investigating the risk factors for adverse hoof conformation in sheep

Can Short-Range Interactions Mediate a Bose Metal Phase in 2D?

We show here based on a 1-loop scaling analysis that short-range interactions are strongly irrelevant perturbations near the insulator-superconductor (IST) quantum critical point. The lack of any proof that short-range interactions mediate physics which is present only in strong coupling leads us to conclude that short-range interactions are strictly irrelevant near the IST quantum critical point. Hence, we argue that no new physics, such as the formation of a uniform Bose metal phase can arise from an interplay between on-site and nearest-neighbour interactions.Comment: 3 pages, 1 .eps file. SUbmitted to Phys. Rev.

Prevalence and temporal dynamics of white line disease in sheep: an exploratory investigation into disease distribution and associated risk factors

Lameness in sheep is a global health, welfare and economic concern. White line disease (WLD), also known as shelly hoof, is a prevalent, non-infectious cause of lameness, characterised by the breakdown of the white line. Little is known about the predisposing factors, nor the individual disease dynamics over time. Our exploratory study aimed to investigate the prevalence and temporal dynamics of WLD, and the associated risk factors. Feet of 400 ewes from four UK commercial sheep farms were inspected for WLD at four time points across 12 months. The change in WLD state at foot-level (develop or recover) was calculated for three transition periods. We present WLD to be widespread, affecting 46.8% of foot-level and 76.6% of sheep-level observations. States in WLD changed over time, with feet readily developing and recovering from WLD within the study period. The presence of WLD at foot-level, the number of feet affected at sheep-level and dynamics in development and recovery were driven by a variety of foot-, sheep- and farm-level factors. We provide key insight into the multifaceted aetiology of WLD and corroborate previous studies demonstrating its multifactorial nature. Our study highlights an opportunity to reduce WLD prevalence and informs hypotheses for future prospective studies

Uptake of the lameness Five-Point Plan and its association with farmer-reported lameness prevalence: a cross-sectional study of 532 UK sheep farmers

The aims of this research were to determine the uptake of a national strategy to reduce lameness in the UK flock, known as the Five-Point Plan (5 P P); explore the association between footrot vaccination (Footvax®) use and 5 P P adoption; investigate the management practices associated with farmer-reported percentage lameness through risk factor analysis; and identify the population attributable fractions of these management practices. In 2014, the 5 P P was launched to provide a practical, farm-level framework to help farmers reduce lameness to reach Farm Animal Welfare Committee (FAWC) targets. No published studies have explicitly explored its uptake in UK flocks nor its association with lameness prevalence. Understanding what parts of the 5 P P farmers adopt and which elements contribute towards the greatest reduction in lameness are integral in informing future strategies. Between November 2018 and February 2019, 532 UK sheep farmers completed a cross-sectional online and paper-based survey. The geometric mean of farmer-reported percentage lameness in ewes was 3.2 % (95 % CI: 2.8–3.6). Farmers adopted a median of 3 points of the plan, but was only fully-adopted by 5.8 % of farmers. The number of points adopted increased with flock size, with larger commercial flocks more likely to cull and vaccinate against footrot, but smaller, pedigree flocks were more likely to treat individual lame sheep. Vaccination was poorly associated with the uptake of other points of the 5 P P. Eight flock management factors were associated with significantly higher percentage lameness in ewes; not carrying out measures to avoid lameness transmission, not quarantining bought in stock, not treating individual lame sheep within three days, maintaining an open flock and foot trimming were all associated with a higher risk of lameness in flocks studied. In addition, using Footvax® for ≤5 years was associated with a higher risk of lameness, although vaccination could be a consequence of high flock lameness or these farmers were not implementing other effective managements, such as treating promptly. The highest PAFs were calculated for trimming lame sheep (16.9 %), maintaining an open flock (13.5 %) and not carrying out measures to avoid lameness transmission (11.8 %). We provide new evidence documenting the benefits of adopting parts of the 5 P P on reducing lameness prevalence in UK flocks, although uptake of these measures could be improved in flocks. Encouraging uptake of these measures could make an important contribution towards reducing the prevalence of lameness and reaching 2021 FAWC ≤ 2% lameness prevalence targets

Sheep farmers’ attitudes towards lameness control: Qualitative exploration of factors affecting adoption of the lameness Five-Point Plan

In 2014, best-practice recommendations to treat and control lameness in sheep in the UK were consolidated into a national program, the Five-Point Plan (5PP). As recent evidence suggests that only the minority of sheep farmers are implementing all management practices listed in the 5PP, qualitative investigation is vital to ensure future promotion is aligned with psychological and contextual factors affecting farmers’ decision-making. This qualitative study sought to explore farmers’ attitudes and the factors affecting uptake of best-practice measures listed in the 5PP. Semi-structured interviews were conducted in 2019 with 12 sheep farmers from England and Wales. In accordance with Thematic Analysis and the principles of Grounded Theory, data collection and analysis were performed iteratively. Two overarching themes, delineated by subthemes, emerged during analysis; (1) Barriers to adoption of 5PP measures and (2) Motivation to adopt 5PP measures. Various farmer-centric factors and physical resources were identified as key barriers or obstacles that limited farmers’ ability to implement 5PP measures outright, or restricted their ability to make changes to facilitate future adoption. Conversely, internal and external influences were identified to increase farmers’ willingness and motivation to implement practices listed on the 5PP. Heterogeneity in farmer perceptions, attitudes, experiences and circumstances identified in this study highlights the difficulty in promoting a one-size-fits-all lameness control plan, where a unique combination of intrinsic factors, social influences, and physical restrictions affect implementation. Future initiatives should focus on removing barriers by changing farmers’ perceptions and mindset towards lameness control, and building farmers’ confidence in their ability to implement practices. Furthermore, farmers’ social licence to farm and their desire to improve their reputation within society, presents an important opportunity to further engage farmers in implementing control practices. Increasing peer-to-peer knowledge transfer opportunities and effective farmer-veterinarian communication and rapport could help establish 5PP measures as normativ