Flat systems, equivalence and trajectory generation

Flat systems, an important subclass of nonlinear control systems introduced via differential-algebraic methods, are defined in a differential geometric framework. We utilize the infinite dimensional geometry developed by Vinogradov and coworkers: a control system is a diffiety, or more precisely, an ordinary diffiety, i.e. a smooth infinite-dimensional manifold equipped with a privileged vector field. After recalling the definition of a Lie-Backlund mapping, we say that two systems are equivalent if they are related by a Lie-Backlund isomorphism. Flat systems are those systems which are equivalent to a controllable linear one. The interest of such an abstract setting relies mainly on the fact that the above system equivalence is interpreted in terms of endogenous dynamic feedback. The presentation is as elementary as possible and illustrated by the VTOL aircraft

Continuum approach to wide shear zones in quasi-static granular matter

Slow and dense granular flows often exhibit narrow shear bands, making them ill-suited for a continuum description. However, smooth granular flows have been shown to occur in specific geometries such as linear shear in the absence of gravity, slow inclined plane flows and, recently, flows in split-bottom Couette geometries. The wide shear regions in these systems should be amenable to a continuum description, and the theoretical challenge lies in finding constitutive relations between the internal stresses and the flow field. We propose a set of testable constitutive assumptions, including rate-independence, and investigate the additional restrictions on the constitutive relations imposed by the flow geometries. The wide shear layers in the highly symmetric linear shear and inclined plane flows are consistent with the simple constitutive assumption that, in analogy with solid friction, the effective-friction coefficient (ratio between shear and normal stresses) is a constant. However, this standard picture of granular flows is shown to be inconsistent with flows in the less symmetric split-bottom geometry - here the effective friction coefficient must vary throughout the shear zone, or else the shear zone localizes. We suggest that a subtle dependence of the effective-friction coefficient on the orientation of the sliding layers with respect to the bulk force is crucial for the understanding of slow granular flows.Comment: 11 pages, 7 figure

Patients at Risk of Complications of Staphylococcus aureus Bloodstream Infection

Staphylococcus aureus is one of the most common causative pathogens of bloodstream infections (BSIs). In approximately one-half of patients with S. aureus BSI, no portal of entry can be documented. This group of patients has a high risk of developing septic metastases. Similarly, patient populations at high risk of S. aureus BSI and BSI-associated complications include patients receiving hemodialysis, injection drug users, patients with diabetes, and patients with preexisting cardiac conditions or other comorbidities. One of the most severe complications of S. aureus BSI is infective endocarditis, and S. aureus is now the most common cause of infective endocarditis in the developed world. Patients with methicillin-resistant S. aureus BSI or infective endocarditis have higher rates of mortality, compared with patients with methicillin-susceptible S. aureus infection. Nasal carriage is the most important source of S. aureus BSI. Better eradication and control strategies, including nasal decolonization and more-active antibiotics, are needed to combat S. aureus BSI

ER Stress in Diabetic Peripheral Neuropathy: A New Therapeutic Target

Significance: Diabetes and other diseases that comprise the metabolic syndrome have reached epidemic proportions. Diabetic peripheral neuropathy (DPN) is the most prevalent complication of diabetes, affecting ?50% of diabetic patients. Characterized by chronic pain or loss of sensation, recurrent foot ulcerations, and risk for amputation, DPN is associated with significant morbidity and mortality. Mechanisms underlying DPN pathogenesis are complex and not well understood, and no effective treatments are available. Thus, an improved understanding of DPN pathogenesis is critical for the development of successful therapeutic options. Recent Advances: Recent research implicates endoplasmic reticulum (ER) stress as a novel mechanism in the onset and progression of DPN. ER stress activates the unfolded protein response (UPR), a well-orchestrated signaling cascade responsible for relieving stress and restoring normal ER function. Critical Issues: During times of extreme or chronic stress, such as that associated with diabetes, the UPR may be insufficient to alleviate ER stress, resulting in apoptosis. Here, we discuss the potential role of ER stress in DPN, as well as evidence demonstrating how ER stress intersects with pathways involved in DPN development and progression. An improved understanding of how ER stress contributes to peripheral nerve dysfunction in diabetes will provide important insight into DPN pathogenesis. Future Directions: Future studies aimed at gaining the necessary insight into ER stress in DPN pathogenesis will ultimately facilitate the development of novel therapies. Antioxid. Redox Signal. 21, 621?633.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140287/1/ars.2013.5807.pd

Comparison of calculated and measured pressures on straight and swept-tip model rotor blades

Using the quasi-steady, full potential code, ROT22, pressures were calculated on straight and swept tip model helicopter rotor blades at advance ratios of 0.40 and 0.45, and into the transonic tip speed range. The calculated pressures were compared with values measured in the tip regions of the model blades. Good agreement was found over a wide range of azimuth angles when the shocks on the blade were not too strong. However, strong shocks persisted longer than predicted by ROT22 when the blade was in the second quadrant. Since the unsteady flow effects present at high advance ratios primarily affect shock waves, the underprediction of shock strengths is attributed to the simplifying, quasi-steady, assumption made in ROT22

Beneficial microorganisms for corals (BMC): proposed mechanisms for coral health and resilience

The symbiotic association between the coral animal and its endosymbiotic dinoflagellate partner Symbiodinium is central to the success of corals. However, an array of other microorganisms associated with coral (i.e., Bacteria, Archaea, Fungi, and viruses) have a complex and intricate role in maintaining homeostasis between corals and Symbiodinium. Corals are sensitive to shifts in the surrounding environmental conditions. One of the most widely reported responses of coral to stressful environmental conditions is bleaching. During this event, corals expel Symbiodinium cells from their gastrodermal tissues upon experiencing extended seawater temperatures above their thermal threshold. An array of other environmental stressors can also destabilize the coral microbiome, resulting in compromised health of the host, which may include disease and mortality in the worst scenario. However, the exact mechanisms by which the coral microbiome supports coral health and increases resilience are poorly understood. Earlier studies of coral microbiology proposed a coral probiotic hypothesis, wherein a dynamic relationship exists between corals and their symbiotic microorganisms, selecting for the coral holobiont that is best suited for the prevailing environmental conditions. Here, we discuss the microbial-host relationships within the coral holobiont, along with their potential roles in maintaining coral health. We propose the term BMC (Beneficial Microorganisms for Corals) to define (specific) symbionts that promote coral health. This term and concept are analogous to the term Plant Growth Promoting Rhizosphere (PGPR), which has been widely explored and manipulated in the agricultural industry for microorganisms that inhabit the rhizosphere and directly or indirectly promote plant growth and development through the production of regulatory signals, antibiotics and nutrients. Additionally, we propose and discuss the potential mechanisms of the effects of BMC on corals, suggesting strategies for the use of this knowledge to manipulate the microbiome, reversing dysbiosis to restore and protect coral reefs. This may include developing and using BMC consortia as environmental "probiotics" to improve coral resistance after bleaching events and/or the use of BMC with other strategies such as human-assisted acclimation/adaption to shifting environmental conditions

Superinfection by Discordant Subtypes of HIV-1 Does Not Enhance the Neutralizing Antibody Response against Autologous Virus

Recent studies have demonstrated that both the potency and breadth of the humoral anti-HIV-1 immune response in generating neutralizing antibodies (nAbs) against heterologous viruses are significantly enhanced after superinfection by discordant HIV-1 subtypes, suggesting that repeated exposure of the immune system to highly diverse HIV-1 antigens can significantly improve anti-HIV-1 immunity. Thus, we investigated whether sequential plasma from these subjects superinfected with discordant HIV-1 subtypes, who exhibit broad nAbs against heterologous viruses, also neutralize their discordant early autologous viruses with increasing potency. Comparing the neutralization capacities of sequential plasma obtained before and after superinfection of 4 subjects to those of matched plasma obtained from 4 singly infected control subjects, no difference in the increase in neutralization capacity was observed between the two groups (p = 0.328). Overall, a higher increase in neutralization over time was detected in the singly infected patients (mean change in IC50 titer from first to last plasma sample: 183.4) compared to the superinfected study subjects (mean change in IC50 titer from first to last plasma sample: 66.5). Analysis of the Breadth-Potency Scores confirmed that there was no significant difference in the increase in superinfected and singly infected study subjects (p = 0.234). These studies suggest that while superinfection by discordant subtypes induces antibodies with enhanced neutralizing breadth and potency against heterologous viruses, the potency to neutralize their autologous viruses is not better than those seen in singly infected patients

Gruta Nova da Columbeira (Bombarral, Portugal): un modelo de ocupación en cueva durante el Paleolítico Medio. Resultados del estudio del registro de macromamíferos

Gruta Nova of Columbeira is one the most important late middle Palaeolithic sites of Portuguese Estremadura and one of the few Portuguese sites in which Neandertal remains have been found. In this paper, we present the zooarchaeological analysis of layers 6 to 9 of the 1962 excvations. Our work provides information about site functionality, human occupation dynamics and the activities these involved. The cave was used both by hominids and carnivores. Furthermore, both human and non-human (biological, hydrological) taphonomical agents seem to have been involved during the formation of the bone assemblages. These facts, together with the dates published by Zilhão et al. (2011), lead us to dismiss the hypothesis that Gruta Nova contains one of the last vestiges of Neanderthals in the Iberian Peninsula.Gruta Nova da Columbeira es uno de los conjuntos del Paleolítico medio más relevantes de la Estremadura Portuguesa y uno de los pocos yacimientos portugueses con restos de neandertal. En este trabajo se presentan los resultados del análisis zooarqueológico y tafonómico de los restos óseos de los macromamíferos recuperados en los niveles 6, 7, 8 y 9 de la excavación arqueológica llevada a cabo en 1962. Este estudio aporta información sobre el uso de la cavidad, el tipo de ocupación y las actividades desarrolladas en la misma. La cueva fue utilizada indistintamente por homínidos y carnívoros. Además, se han identificado otros agentes tafonómicos no antrópicos que han intervenido en la formación del registro óseo. Estos datos junto con los resultados de las dataciones aportadas por Zilhão y otros (2011) nos lleva a considerar que no es posible mantener que Gruta Nova sea uno de los últimos vestigios de la permanencia de los neandertales en el sur de la Península Ibérica, como se ha venido haciendo hasta ahora