The Radical and the Republican: Frederick Douglass, Abraham Lincoln, and the Triumph of Antislavery Politics

Ending Slavery The Converging Paths of Lincoln and Douglass This book explores the different paths that Frederick Douglass and Abraham Lincoln took in freeing the slaves. It provides a well-written and extremely insightful dialogue between the radical and the conservative, althou...

Maintaining Institutional Historical Collections through Rapid Appraisal of Employee Files

In the past decade, institutions like the National Agricultural Library (NAL) have not consistently preserved records documenting their history. This lack of documentation has the potential to damage the credibility and transparency of federal institutions like the NAL. This paper considers how employee’s personal work files can supplement other records to document the history of federal institutions, and suggests procedures for rapid, systematic appraisal of employees’ files to support efficient collection development. In an effort to fill gaps in the historical record of the NAL, Susan McCarthy, Associate Director for the NAL’s Knowledge Services Division, donated her collected analog and digital work papers—amassed over a thirty-year career—to NAL Special Collections. McCarthy also hired two archives fellows (the authors of this report) to assist Special Collections with processing her collected documents, and to conduct research on rapid appraisal methods to support efficient processing of this very large collection. We conducted an initial survey of McCarthy’s files and found valuable information pertaining to events and activities in the history of the NAL. In order to rapidly appraise those materials for the collection, we crafted a collection development policy specific for McCarthy’s documents by researching policies at other national libraries. The results uncovered in this process indicate that institutions should seriously consider supplementing historical collections with employee’s work files, and conducting outreach for external help when appraising donations for these collections.This paper is the product of research conducted under a Non-Assistance Cooperative Agreement #58-8260-6-003 between the University of Maryland and the USDA, ARS, National Agricultural Library

National Safe Schools Framework: Policy and Practice to Reduce Bullying in Australian Schools

In 2003 Australia was one of the first countries to develop an integrated national policy, called the National Safe Schools Framework (NSSF), for the prevention and management of violence, bullying, and other aggressive behaviors. The effectiveness of this framework has not yet been formally evaluated. Cross-sectional data collected in 2007 from 7,418 students aged 9 to 14 years old and 453 teachers from 106 representative Australian schools were analyzed to determine teachers’ perceptions about the extent of implementation of the NSSF, teachers’ capacity to address student bullying, and students’ reports of bullying in their school, 4 years following the framework’s dissemination. While methodological issues limit the findings, schools appear not to have widely implemented the recommended safe school practices, teachers appear to need more training to address bullying, especially covert bullying, and bullying prevalence among students seems relatively unchanged compared to Australian data collected 4 years prior to the launch of the NSSF

Development and Validation of a Simple Method for the Detection of Fascaplysin in Plasma

Fascaplysin is a cytotoxic natural product isolated from a variety of Indo-Pacific marine organisms, primarily Fascaplysinopsis sponges and Didemnum tunicates. Positive xenograft studies involving this alkaloid structural class have indicated that fascaplysin may serve as an important lead compound for preclinical development. This study was undertaken as a prelude to a full pharmacokinetics and therapeutic assessment of fascaplysin. We describe here a simple plasma preparation and a rapid HPLC method for the detection of fascaplysin in mice. The method was validated by parameters including good linear correlation, a limit of quantification of 107.1 μg/ mL, and a good precision with a coefficient of variation of 0.92% for 10 μg/mL. This method provides excellent sensitivity and visualization of fascaplysin as a single peak allowing for rapid analysis of plasma samples involving absorption, distribution, and metabolism studies. A preliminary pharmacokinetics study in C57Bl/6 mice using 20.6 mg/kg fascaplysin yielded a biphasic curve with T½α=16.7 min, T½β=11.7 h, and C0 of 17.1 μg/mL

Can Honey Bees Assist in Area Reduction and Landmine Detection?

Honey bees have recently received considerable attention from the popular press as an innovative method to detect a variety of explosives, landmines and UXO. Many of these reports are inaccurate and may encourage individuals and demining groups to “sell” a service that they poorly understand or lack the experience to properly apply. As the developers of this technology, we offer the following summary about the current status of this alternative for landmine detection, including its strengths and limitations

Data rescue: An assessment framework for legacy research collections

Widespread investments in the reproducibility and reuse of scientific data have spurred an increasing recognition of the potential value of data biding in unpublished records and collections of legacy research materials, such as scientists’ papers, historical publications, and working files. Recovering usable scientific data from legacy collections constitutes one kind of data rescue: the application of selected data curation processes to data at imminent risk of loss. Given the growing interest in data-intensive science and growing movement toward computationally amenable collections in memory institutions, the National Agricultural Library and other curation institutions need systematic approaches to processing legacy collections with the specific goal of retrieving reusable or historically valuable scientific data. This white paper reports on research conducted under the auspices of the Digital Curation Fellows Program, a collaborative research initiative of the United States Department of Agriculture’s National Agricultural Library and the University of Maryland College of Information Studies. We offer a framework for assessing collections of scientific records for the purpose of data rescue, developed through research on three case studies of agricultural research collections. This framework aims to guide data rescue initiatives at the National Agricultural Library and other agricultural research centers, and to provide conceptual and practical framing for emerging conversations around data rescue in the agricultural research community and across disciplines.This white paper is the product of research conducted under a Non-Assistance Cooperative Agreement #58-8260-6-003 between the University of Maryland and the United States Department of Agriculture (USDA), Agricultural Research Service (ARS), National Agricultural Library with funding provided by the USDA, ARS, Office of National Programs

Effects of canagliflozin on myocardial infarction:a post hoc analysis of the CANVAS Program and CREDENCE trial

AIMS: Given the benefits of sodium glucose co-transporter 2 inhibition (SGLT2i) in protecting against heart failure in diabetic patients, we sought to explore the potential impact of SGLT2i on the clinical features of patients presenting with myocardial infarction (MI) through a post-hoc analysis of CANVAS Program and CREDENCE trial.METHODS AND RESULTS: Individuals with type 2 diabetes and history or high risk of cardiovascular disease (CANVAS Program) or type 2 diabetes and chronic kidney disease (CREDENCE) were included. The intervention was Canagliflozin 100 or 300 mg (combined in the analysis) or placebo. MI events were adjudicated as ST-elevation myocardial infarction (STEMI), non-STEMI as well as type 1 MI or type 2 MI. 421 first MI events in the CANVAS Program and 178 first MI events in the CREDENCE trial were recorded (83 fatal, 128 STEMI, 431 non-STEMI, and 40 unknown). No benefit of canagliflozin compared with placebo on time to first MI event was observed (HR 0.89; 95% CI 0.75, 1.05). Canagliflozin was associated with lower risk for non-STEMI (HR 0.78; 95% CI 0.65, 0.95) but suggested a possible increase in STEMI (HR 1.55; 95% CI 1.06, 2.27), with no difference in risk of type 1 or type 2 MI. There was no change in fatal MI (HR 1.22, 95% CI 0.78, 1.93).CONCLUSIONS: Canagliflozin was not associated with a reduction in overall MI in the pooled CANVAS Program and CREDENCE trial population. The possible differential effect on STEMI and Non-STEMI observed in the CANVAS cohort warrants further investigation.</p

Symbiotic modeling: Linguistic Anthropology and the promise of chiasmus

Reflexive observations and observations of reflexivity: such agendas are by now standard practice in anthropology. Dynamic feedback loops between self and other, cause and effect, represented and representamen may no longer seem surprising; but, in spite of our enhanced awareness, little deliberate attention is devoted to modeling or grounding such phenomena. Attending to both linguistic and extra-linguistic modalities of chiasmus (the X figure), a group of anthropologists has recently embraced this challenge. Applied to contemporary problems in linguistic anthropology, chiasmus functions to highlight and enhance relationships of interdependence or symbiosis between contraries, including anthropology’s four fields, the nature of human being and facets of being human

Development and validation of a rapid method for the detection of latrunculol A in plasma

Latrunculol A is a recently discovered 6,7-dihydroxy analog of the potent actin inhibitor latrunculin A. Latrunculol A has exhibited greater cytotoxicity than latrunculin A against both murine and human colon tumor cell lines in vitro. Currently, there are no reports regarding the bioavailability of latrunculol A in vivo. This study was undertaken as a prelude to pharmacokinetic assessments and it is the first work where bioavailability of latrunculol A was studied. In the present work, a simple plasma preparation and a rapid HPLC method have been developed. Mouse plasma containing latrunculol A was first treated by acetonitrile and then centrifuged at 14,000 rpm at 4 °C for 25 min. The supernatant was injected in an HPLC system comprising a Waters Symmetry NH2 column, a mobile phase of acetonitrile/water (95/5, v/v), a flow rate of 1.0 mL/min, at 220 nm. The method was validated by parameters including a good linear correlation, a limit of quantification of 9 ng/mL, and a good precision with a coefficient variation of 1.65, 1.86, and 1.26% for 20, 400, and 800 ng/mL, respectively. With this simple method, excellent separation and sensitivity of latrunculol A are achieved, thus allowing a rapid analysis of the plasma samples for absorption, distribution, and metabolism studies