Light vector correlator in medium: Wilson coefficients up to dimension 6 operators

As an improvement of the QCD sum rule method to study modifications of light vector mesons in nuclear matter and/or at finite temperature, we calculate the Wilson coefficients of all independent gluonic non-scalar operators up to dimension 6 in the operator product expansion (OPE) of the vector channel for light quarks. To obtain the gluon part of the light quark OPE from the heavy quark one, we also compute the heavy quark expansion of the relevant quark condensates. Together with the results for the quark operators that are already available in the literature, this completes the OPE of the vector channel in a hot or dense medium for operators up to dimension 6.Comment: 6 pages, no figur

FAK-mediated mechanotransduction in skeletal regeneration

The majority of cells are equipped to detect and decipher physical stimuli, and then react to these stimuli in a cell type-specific manner. Ultimately, these cellular behaviors are synchronized to produce a tissue response, but how this is achieved remains enigmatic. Here, we investigated the genetic basis for mechanotransduction using the bone marrow as a model system. We found that physical stimuli produced a pattern of principal strain that precisely corresponded to the site-specific expression of sox9 and runx2, two transcription factors required for the commitment of stem cells to a skeletogenic lineage, and the arrangement and orientation of newly deposited type I collagen fibrils. To gain insights into the genetic basis for skeletal mechanotransduction we conditionally inactivated focal adhesion kinase (FAK), an intracellular component of the integrin signaling pathway. By doing so we abolished the mechanically induced osteogenic response and thus identified a critical genetic component of the molecular machinery required for mechanotransduction. Our data provide a new framework in which to consider how physical forces and molecular signals are synchronized during the program of skeletal regeneration

Semiautomatische Katalogisierung und Normdatenverknüpfung mit Zotero im Index Theologicus

Im Folgenden soll aufgezeigt werden, wie derzeit das Literaturverwaltungsprogramm Zotero innerhalb des Index Theologicus genutzt wird, um unselbstständige Literatur in einem bibliothekarischen Katalogisierungssystem zu erfassen. Die modulare und flexible Architektur der Open Source Software erlaubt es, die bereits kollaborativ zusammengetragene Programmierarbeit zur Datenextraktion mitzunutzen. Das vorgestellte semiautomatische Verfahren bringt auch bei der Verknüpfung von Normdaten erhebliche Vorteile für die Medienbearbeitung

PinAPL-Py: A comprehensive web-application for the analysis of CRISPR/Cas9 screens.

Large-scale genetic screens using CRISPR/Cas9 technology have emerged as a major tool for functional genomics. With its increased popularity, experimental biologists frequently acquire large sequencing datasets for which they often do not have an easy analysis option. While a few bioinformatic tools have been developed for this purpose, their utility is still hindered either due to limited functionality or the requirement of bioinformatic expertise. To make sequencing data analysis of CRISPR/Cas9 screens more accessible to a wide range of scientists, we developed a Platform-independent Analysis of Pooled Screens using Python (PinAPL-Py), which is operated as an intuitive web-service. PinAPL-Py implements state-of-the-art tools and statistical models, assembled in a comprehensive workflow covering sequence quality control, automated sgRNA sequence extraction, alignment, sgRNA enrichment/depletion analysis and gene ranking. The workflow is set up to use a variety of popular sgRNA libraries as well as custom libraries that can be easily uploaded. Various analysis options are offered, suitable to analyze a large variety of CRISPR/Cas9 screening experiments. Analysis output includes ranked lists of sgRNAs and genes, and publication-ready plots. PinAPL-Py helps to advance genome-wide screening efforts by combining comprehensive functionality with user-friendly implementation. PinAPL-Py is freely accessible at http://pinapl-py.ucsd.edu with instructions and test datasets

Measuring and Controlling Social Desirability Bias: Applications in Information Systems Research

Despite the potential risks that social desirability (SD) bias poses to the validity of information systems (IS) research, little is known about the extent of such bias. This study examines the extent of SD bias in the IS domain and compares alternative techniques for measuring it. Our findings suggest that despite the popularity of the Marlowe-Crowne scale in IS research, the impression management scale functions better in assessing the extent of SD bias. We also found that under certain circumstances, SD bias can threaten the validity of IS research. This study contributes to the IS literature by showing the difference in SD bias across IS contexts and suggesting an effective way to test for the presence of SD bias