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Classifying general nonlinear force laws in cell-based models via the continuum limit
though discrete cell-based frameworks are now commonly used to simulate a whole range of biological phenomena, it is typically not obvious how the numerous different types of model are related to one another, nor which one is most appropriate in a given context. Here we demonstrate how individual cell movement on the discrete scale modeled using nonlinear force laws can be described by nonlinear diffusion coefficients on the continuum scale. A general relationship between nonlinear force laws and their respective diffusion coefficients is derived in one spatial dimension and, subsequently, a range of particular examples is considered. For each case excellent agreement is observed between numerical solutions of the discrete and corresponding continuum models. Three case studies are considered in which we demonstrate how the derived nonlinear diffusion coefficients can be used to (a) relate different discrete models of cell behavior; (b) derive discrete, intercell force laws from previously posed diffusion coefficients, and (c) describe aggregative behavior in discrete simulations
On the formation time scale and core masses of gas giant planets
Numerical simulations show that the migration of growing planetary cores may
be dominated by turbulent fluctuations in the protoplanetary disk, rather than
by any mean property of the flow. We quantify the impact of this stochastic
core migration on the formation time scale and core mass of giant planets at
the onset of runaway gas accretion. For standard Solar Nebula conditions, the
formation of Jupiter can be accelerated by almost an order of magnitude if the
growing core executes a random walk with an amplitude of a few tenths of an au.
A modestly reduced surface density of planetesimals allows Jupiter to form
within 10 Myr, with an initial core mass below 10 Earth masses, in better
agreement with observational constraints. For extrasolar planetary systems, the
results suggest that core accretion could form massive planets in disks with
lower metallicities, and shorter lifetimes, than the Solar Nebula.Comment: ApJL, in pres
Molecular characterisation of four double-flowered mutants of Silene dioica representing four centuries of variation
Records of double-flowered Silene dioica date from the late sixteenth century and four named varieties are grown today, as previously, for their horticultural interest. Although double-flowered mutants have been characterized in several plants, their study in dioecious species is of particular interest due to influences of the homeotic mutation on the different floral whorl configurations in males and females. We have analysed four double-flowered varieties of Silene dioica: Flore Pleno and Rosea Plena date back to the seventeenth and nineteenth centuries, Thelma Kay and Firefly were recognized in the latter part of the twentieth and early twenty-first centuries. We have analysed the floral structure of the four varieties, which have distinct floral architectures. Based on Y chromosome-specific PCR analysis we show that Firefly is male and that the other three varieties are female: Random Amplification of Polymorphic DNA (RAPD) analyses suggested a common origin for the three female varieties. The double-flowered phenotype in all four varieties is caused by mutation of the C-function MADS-box transcription factor gene SDM1. We show that Firefly carries a unique 44bp insertion into SDM1, revealing an independent origin for this variety. Comparative analysis of SDM1 cDNA and genomic sequences in Flore Pleno, Rosea Plena and Thelma Kay shows that all three are caused by the same 7bp insertion within SDM1 and therefore share a common origin. The three alleles also differ by several single nucleotide polymorphisms, which represent somatic mutations accumulated over four centuries of asexual propagation
Thermoelectric and Magnetothermoelectric Transport Measurements of Graphene
The conductance and thermoelectric power (TEP) of graphene is simultaneously
measured using microfabricated heater and thermometer electrodes. The sign of
the TEP changes across the charge neutrality point as the majority carrier
density switches from electron to hole. The gate dependent conductance and TEP
exhibit a quantitative agreement with the semiclassical Mott relation. In the
quantum Hall regime at high magnetic field, quantized thermopower and Nernst
signals are observed and are also in agreement with the generalized Mott
relation, except for strong deviations near the charge neutrality point
Mesoscopic and continuum modelling of angiogenesis
Angiogenesis is the formation of new blood vessels from pre-existing ones in
response to chemical signals secreted by, for example, a wound or a tumour. In
this paper, we propose a mesoscopic lattice-based model of angiogenesis, in
which processes that include proliferation and cell movement are considered as
stochastic events. By studying the dependence of the model on the lattice
spacing and the number of cells involved, we are able to derive the
deterministic continuum limit of our equations and compare it to similar
existing models of angiogenesis. We further identify conditions under which the
use of continuum models is justified, and others for which stochastic or
discrete effects dominate. We also compare different stochastic models for the
movement of endothelial tip cells which have the same macroscopic,
deterministic behaviour, but lead to markedly different behaviour in terms of
production of new vessel cells.Comment: 48 pages, 13 figure
Heavy landings of whelks, Babylonia spp. in trawl catches off Quilon, southwest coast of India
Whelks are recently being exploited from east and
west coasts of India on a commercial basis for
meat export trade. Babylonia spirata and
B. zeylanica are the two species of whelks
which form bycatch of shrimp trawlers in
Sakthikulangara-Neendakara area along the
southwest coast of India and the former species
contributes to the fishery along Annappanpettai,
near Portonovo along the southeast coast of
India
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