52 research outputs found
Overview of Licensing Platforms based on Distributed Ledger Technology
The licensing of creative work is of broad and current interest. The European Commission proposes that when uploading a licensed digital work, the uploader should be checked by the system that one has the necessary rights. Technically this law is difficult to implement, as images with different intentions are shared, and even small changes like watermarks make it difficult to reveal similarities. The characteristics of distributed ledger technology could provide excellent support for the licensing and management of the rights of use. In this work, non-technical and technical criteria are defined to achieve an overview of the state-of-the-art solutions in the field of blockchain-based licensing platforms. Based on the criteria, different licensing platforms are reviewed, and the results are presented in a comparison matrix
Der Nachweis von isolierten Tumorzellen in Knochenmark und Blut von Patientinnen mit primĂ€rem Mammakarzinom â Standardisierte Methodik und klinische Relevanz
Toxicity Analysis in the ADEBAR Trial: Sequential Anthracycline-Taxane Therapy Compared with FEC120 for the Adjuvant Treatment of High-Risk Breast Cancer
Background: Data from meta-analyses have shown taxane-containing therapies to be superior to anthracycline-based treatments for high-risk breast cancer. Patients and Methods: The ADEBAR trial was a multicenter phase Ill trial in which patients with lymph node-positive breast cancer were prospectively randomized for either sequential anthracycline-taxane or FEC120 therapy. Patients received 4x epirubicin (90 mg/m(2)) and cyclophosphamide (600 mg/m(2)) every 3 weeks (q3w), followed by 4x docetaxel (100 mg/m(2)) q3w (EC-Doc arm), or 6x epirubicin (60 mg/m(2)) and 5-fluorouracil (500 mg/m(2)) on days 1 and 8 and cyclophosphamide (75 mg/m(2)) on days 1-14, q4w (FEC arm). We compared both arms with respect to toxicity and feasibility. Results: Hematological toxicity was found significantly more often in the FEC arm. Febrile neutropenia was seen in 11.3% of patients in the FEC arm and in 8.4% of patients in the EC-Doc arm (p = 0.027). Non-hematological side effects of grade 3/4 were rarely seen in either arm. Therapy was terminated due to toxicity in 3.7% of the patients in the EC-Doc arm and in 8.0% of the patients in the FEC arm (p = 0.0009). Conclusion: The sequential anthracycline-taxane regimen is a well-tolerated and feasible alternative to FEC120 therapy
Preparation and Single-Crystal X-Ray Structures of Four Related Mixed-Ligand 4-Methylpyridine Indium Halide Complexes
We describe the structures of four related indium complexes obtained during synthesis of solid-state materials precursors. Indium adducts of halides and 4-methylpyridine, InX3(pic)3 (X = Cl, Br; pic = 4-methylpyridine) consist of octahedral molecules with meridional (mer) geometry. Crystals of mer-InCl3(pic)3 (1) are triclinic, space group P1(bar) (No. 2), with a = 9.3240(3), b = 13.9580(6), c = 16.7268 (7) A, alpha = 84.323(2), beta = 80.938(2), gamma = 78.274(3)Z = 4, R = 0.035 for 8820 unique reflections. Crystals of mer-InBr3(pic)3 (2) are monoclinic, space group P21/n (No. 14), with a = 15.010(2), b = 19.938(2), c = 16.593(3), beta = 116.44(1)Z = 8, R = 0.053 for 4174 unique reflections. The synthesis and structures of related compounds with phenylsulfide (chloride) (3) and a dimeric complex with bridging hydroxide (bromide) (4) coordination is also described. Crystals of trans-In(SC6H5)Cl2(pic)3 (3) are monoclinic, space group P21/n (No. 14), with a = 9.5265(2), b = 17.8729(6), c = 13.8296(4), beta = 99.7640(15)Z = 4, R = 0.048 for 5511 unique reflections. Crystals of [In(mu-OH)Br2(pic)22 (4) are tetragonal, space group = I41cd (No. 110) with a = 19.8560(4), b = 19.8560(4), c = 25.9528(6), Z = 8, R = 0.039 for 5982 unique reflections
On the uniqueness of solutions to the periodic 3D Gross-Pitaevskii hierarchy
In this paper, we present a uniqueness result for solutions to the
Gross-Pitaevskii hierarchy on the three-dimensional torus, under the assumption
of an a priori spacetime bound. We show that this a priori bound is satisfied
for factorized solutions to the hierarchy which come from solutions of the
nonlinear Schr\"{o}dinger equation. In this way, we obtain a periodic analogue
of the uniqueness result on previously proved by Klainerman and
Machedon, except that, in the periodic setting, we need to assume additional
regularity. In particular, we need to work in the Sobolev class
for . By constructing a specific counterexample, we show that, on
, the existing techniques don't apply in the endpoint case
. This is in contrast to the known results in the non-periodic
setting, where the these techniques are known to hold for all .
In our analysis, we give a detailed study of the crucial spacetime estimate
associated to the free evolution operator. In this step of the proof, our
methods rely on lattice point counting techniques based on the concept of the
determinant of a lattice. This method allows us to obtain improved bounds on
the number of lattice points which lie in the intersection of a plane and a set
of radius , depending on the number-theoretic properties of the normal
vector to the plane. We are hence able to obtain a sharp range of admissible
Sobolev exponents for which the spacetime estimate holds.Comment: 42 page
Use of music during vaginal birth and caesarean section: an interprofessional survey
PURPOSE: Evidence abounds about the beneficial effects of music on patients and healthcare professionals for many medical indications. This study aimed to evaluate the dissemination and use of music in the obstetrical setting. METHODS: Invitations to an online survey were sent to physicians and midwives of all obstetrics departments in Germany. The survey gathered descriptive data as well as information about the personal relation to music and the use of it during vaginal birth (VB) and caesarean section (CS) and whether data about positive or negative effects of music were known to the participant. RESULTS: In total, there were 293 respondents. The 47% that had the means to play music during CS stated that music was played in 15% of the cases. Most respondents have the means to play music during VB (97%). Music is played in 38% of VB. Regardless of the mode of delivery, music was estimated to be positive for team communication and patient communication. It was also deemed calming and mood lifting on the respondents. Regarding the patient, music during CS and VB was rated as being positive on all scales. Listening to music was recommended more often during VB (66%) than CS (38%). CONCLUSIONS: Although healthcare professionals are mostly aware of the beneficial effects of music in obstetrics, our study shows that music plays a more important role during VB than during CS in Germanys obstetrical wards. There is a lack of equipment to play music in operation theatres where CS take place
The influence of maternal singing on well-being, postpartum depression and bonding â a randomised, controlled trial
BACKGROUND: Postpartum depression is fairly common in new mothers and moreover associated with impaired bonding and poor maternal well-being. The aim of the present study was to investigate the impact of a mother-infant singing intervention within the first three months after birth on maternal well-being, depressive symptoms and bonding. METHODS: 120 women who were recruited at the maternity ward at the University Clinic in DĂŒsseldorf took part in this prospective, randomised-controlled study. Beside the baseline measurement 1â3âdays after childbirth, depressive symptoms, maternal well-being and mother-infant bonding were evaluated with questionnaires before (two weeks after birth) and after (twelve weeks after birth) the intervention took place. The experimental group (nâ=â59) participated in several singing intervention sessions while the control group (nâ=â61) did not. In the intervention group, salivary cortisol as well as attachment and mood were assessed immediately before and after the singing sessions. RESULTS: The participants of the intervention group showed a significant reduction of cortisol (pâ=â.023) and an improvement of attachment and mood from start to end of the intervention session (all pââ€â.008). However, no prolonged effects were revealed beyond the intervention sessions as the two groups did not differ regarding the alterations of the primary outcomes postpartum depression (interaction effect pâ=â.187) and postpartum bonding (interaction effect pâ=â.188) in the 10-week period from two up to twelve weeks after childbirth (all pâ>â.05). Additional analyses of singing habits at home in both groups, revealed that only in the singing group more frequent singing was associated with less anxiety and more well-being of the mother. CONCLUSION: Singing towards the infant seems to have positive immediate effects on the well-being of new mothers (on subjective variables as well as physiological measurements). However, the intervention did not lead to more long lasting positive effects although several limitations should be considered. TRIAL REGISTRATION: DRKS00015178 (registered at the German Clinical Trial Registry), date of registration: 09.11.2018
Rationale and description of a lifestyle intervention programme to achieve moderate weight loss in women with non-metastatic breast cancer: the lifestyle intervention part of the SUCCESS C study
Research diaries as a method in a participatory research project on music therapy with women affected by endometriosis (TRIO)
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