351 research outputs found
Cost of Feed per Pound of Gain in Cal Poly\u27s Dairy Calves
California is ranked one of the top five states in the United States for dairy production. It produces approximately 40 billion pounds of milk per year for US production. California’s dairy industry is not only the largest milk producer in the nation, but it is also the most financially prominent in the agricultural industry. This industry lead is purely because of its careful management practices. The way calves are raised depend on the resources used, the natural environment present, and the operation of the dairy farm. Essentially, there are numerous ways to care for a cow and calf. However, the aim of raising calves is to ensure productive cows are raised. Calves are the future of the heard. With good management techniques, a newborn heifer calf will eventually develop into a high milk-producing cow. As the heifer grows, it is important to watch her weight and rate of gain. Since feed is the number one cost on a dairy, it is important to achieve optimum growth with low costs
Prospective Changes in Energy Intake, Physical Activity, and Resting Energy Expenditure during Pregnancy
Background and Purpose: Prenatal changes in energy intake (EI), physical activity (PA), and resting energy expenditure (REE) are important determinants of future health and obesity outcomes. This study examined changes in EI, PA and REE in 16 adult, pregnant women (75% Normal-weight, 15% overweight/obese) early in pregnancy (<16 weeks), mid-pregnancy (24 weeks) and late-pregnancy (32-weeks). Results: From early to mid-pregnancy, women gained an average of 3.7 ± 2.9 kg; EI remained relatively constant (-74 ± 826 kcal/d), PA levels declined by -574 ± 1180 Metabolic Equivalent (METS)*min/wk, and REE increased 122 ± 326 kcal/d. From mid-pregnancy to late-pregnancy, women gained 5.9 ± 2.4 kg; EI increased by 279 ± 352 kcal/d, PA levels increased (460 ± 2000 METS*min/wk) but remained 393 METS*min/wk below early in pregnancy, and REE increased by 251 ± 218 kcal/d. Weight gain trajectories were consistent with IOM recommendations for healthy gestational weight gain (GWG). Conclusions: Findings suggest among women with health GWG, a pattern of gradual and relatively small increases in reported EI and REE is expected, with marginal declines in PA throughout pregnancy. Future research with a larger sample size should identify specific caloric and exercise goals associated with healthy GWG and pregnancy health outcomes
Promoting Weight Loss Before Pregnancy: Feasible or Futile?
Pre-pregnancy obesity is a well-established risk factor for several adverse maternal and fetal outcomes, including gestational diabetes, hypertension, cesarean sections, and fetal macrosomia. Weight loss before pregnancy could help prevent such complications, but the feasibility of such an approach remains unknown. The current study examined the feasibility of a 3-month pre-pregnancy behavioral weight loss program in 12 overweight/obese women planning pregnancy. The 3 month program resulted in an average 5.4 ± 3.0 kg weight loss and significant improvements in self-monitoring, physical activity, eating and exercise self-efficacy, and healthy eating (p \u3c 0.04). By the end of the 9 month follow-up, half of sample (n = 6) had conceived. Women reported significant increases in weekly or more frequent self-weighing (p \u3c 0.0001), counting calories (p \u3c 0.001), consuming fruit and vegetables (p = 0.007), and cutting out fat (p = 0.0001) and junk foods (p = 0.002). A lifestyle modification program to promote weight loss before pregnancy promoted clinically significant weight loss and appeared feasible
Effect of an Internet-Based Program on Weight Loss for Low-Income Postpartum Women: A Randomized Clinical Trial
Does an internet-based weight loss program promote long-term weight loss in low-income postpartum women in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC program)
Identity, enlightenment and political dissent in late colonial Spanish America
During the long crisis of the Spanish empire between 1810 and 1825, the Creole leaders of Spanish American independence asserted a new identity for the citizens of the states which they sought to establish, calling them 'Americanos'. This general title was paralleled and often
supplanted by other political neologisms, as movements for independence and new polities took shape in the various territories of Spanish America. In New Spain, the insurgents who fought against royalist government during the decade after 181 o tried to rally fellow 'Mexicans' to a common cause; at independence in 1821, die Creole political leadership created a 'Mexican empire', the title of which, with its reference to the Aztec empire which had preceded Spain's conquest, was designed to evoke a 'national' history shared by all members of Mexican society. In South America, die leaders of the new republics also sought to promote patriotic feelings for territories which had been converted from administrative units of Spanish government into independent states. Thus, San Martin and O'Higgins convoked
'Chileans' to the cause of independence in the old Captaincy-General of Chile; shortly afterwards and with notably less success, San Martin called upon 'Peruvians' to throw off Spanish rule. Bolivar was, likewise, to call 'Colombians' to his banner in die erstwhile Viceroyalty of New Granada, before advancing south to liberate Peru in die name of 'Peruvians', and Upper Peru in die name of 'Bolivians', where die Republic which his military feats and political vision made possible was named after him
Preservation of Ovarian Function after Hematopoietic Cell Transplantation (HCT): More Possible Than We Thought?
Microdevices for extensional rheometry of low viscosity elastic liquids : a review
Extensional flows and the underlying stability/instability mechanisms are of extreme relevance to the efficient operation of inkjet printing, coating processes and drug delivery systems, as well as for the generation of micro droplets. The development of an extensional rheometer to characterize the extensional properties of low viscosity fluids has therefore stimulated great interest of researchers, particularly in the last decade. Microfluidics has proven to be an extraordinary working platform and different configurations of potential extensional microrheometers have been proposed. In this review, we present an overview of several successful designs, together with a critical assessment of their capabilities and limitations
Functional genetic variation in pe/ppe genes contributes to diversity in Mycobacterium tuberculosis lineages and potential interactions with the human host.
INTRODUCTION: Around 10% of the coding potential of Mycobacterium tuberculosisis constituted by two poorly understood gene families, the pe and ppe loci, thought to be involved in host-pathogen interactions. Their repetitive nature and high GC content have hindered sequence analysis, leading to exclusion from whole-genome studies. Understanding the genetic diversity of pe/ppe families is essential to facilitate their potential translation into tools for tuberculosis prevention and treatment. METHODS: To investigate the genetic diversity of the 169 pe/ppe genes, we performed a sequence analysis across 73 long-read assemblies representing seven different lineages of M. tuberculosis and M. bovis BCG. Individual pe/ppe gene alignments were extracted and diversity and conservation across the different lineages studied. RESULTS: The pe/ppe genes were classified into three groups based on the level of protein sequence conservation relative to H37Rv, finding that >50% were conserved, with indels in pe_pgrs and ppe_mptr sub-families being major drivers of structural variation. Gene rearrangements, such as duplications and gene fusions, were observed between pe and pe_pgrs genes. Inter-lineage diversity revealed lineage-specific SNPs and indels. DISCUSSION: The high level of pe/ppe genes conservation, together with the lineage-specific findings, suggest their phylogenetic informativeness. However, structural variants and gene rearrangements differing from the reference were also identified, with potential implications for pathogenicity. Overall, improving our knowledge of these complex gene families may have insights into pathogenicity and inform the development of much-needed tools for tuberculosis control
BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers
Background: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormone-related cancers.
Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76 637 cancer case patients and 83 796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided.
Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9x10- 6) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8x10-3). These associations were stronger for serous ovarian cancer and for estrogen receptor–negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10-5 and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10-5, respectively). For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. No association with prostate cancer was observed.
Conclusions: Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations
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