3,773 research outputs found
Fluorimetric methods for the measurement of intermediate metabolites (lactate, pyruvate, alanine, β-hydroxybutyrate, glycerol) using a COBAS FARA centrifugal analyser
Intermediate products of the metabolism of glucose, fat and amino-acid are important in the evaluation of such metabolic disorders as diabetes mellitus, liver disease and metabolic acidosis. In the present study, methods for the measurement of intermediate metabolites (lactate, pyruvate, alanine, β-hydroxybutyrate and glycerol) have been adapted to a fast centrifugal analyzer: the COBAS FARA. Correlation coeffcients rangedfrom 0.90 to 0.99, compared to established manual spectrophotometric methods. Within-run coeffcients of variation (CVs) ranged between 2.9 and 8.8% at low levels, between 1.5 and 5.7% at medium levels and between 1.2 and 5.6% at high levels. Between-run CVs were between 4.0 and 15.0% at low levels, between 1.7 and 7.0% at medium levels and between 1.3 and 2.7% at high levels. These fluorimetric assays for the determination of intermediate metabolites on COBAS FARA (Roche) have a good sensitivity and precision, are less costly than manual methods and can be used on a routine basis
Differentiating between Hemorrhagic Infarct and Parenchymal Intracerebral Hemorrhage
Differentiating hemorrhagic infarct from parenchymal intracerebral hemorrhage can be difficult. The immediate and long-term management of the two conditions are different and hence the importance of accurate diagnosis. Using a series of intracerebral hemorrhage cases presented to our stroke unit, we aim to highlight the clues that may be helpful in distinguishing the two entities. The main clue to the presence of hemorrhagic infarct on computed tomography scan is the topographic distribution of the stroke. Additional imaging modalities such as computed tomography angiogram, perfusion, and magnetic resonance imaging may provide additional information in differentiating hemorrhagic infarct from primary hemorrhages
Bit-Vector Model Counting using Statistical Estimation
Approximate model counting for bit-vector SMT formulas (generalizing \#SAT)
has many applications such as probabilistic inference and quantitative
information-flow security, but it is computationally difficult. Adding random
parity constraints (XOR streamlining) and then checking satisfiability is an
effective approximation technique, but it requires a prior hypothesis about the
model count to produce useful results. We propose an approach inspired by
statistical estimation to continually refine a probabilistic estimate of the
model count for a formula, so that each XOR-streamlined query yields as much
information as possible. We implement this approach, with an approximate
probability model, as a wrapper around an off-the-shelf SMT solver or SAT
solver. Experimental results show that the implementation is faster than the
most similar previous approaches which used simpler refinement strategies. The
technique also lets us model count formulas over floating-point constraints,
which we demonstrate with an application to a vulnerability in differential
privacy mechanisms
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Comparison of amplified spontaneous emission pulse cleaners for use in chirped pulse amplification front end lasers
We compare various schemes for removing amplified spontaneous emission from seed laser pulses. We focus on compact schemes that are compatible with fiber laser front end systems with pulse energies in the 10nJ-1{micro}J range and pulse widths in the 100fs-10ps range. Pre-pulse contrast ratios greater than 10{sup 9} have been measured
Excitonic resonances in the 2D extended Falicov-Kimball model
Using the projector-based renormalization method we investigate the formation
of the excitonic insulator phase in the two-dimensional (2D) spinless
Falicov-Kimball model with dispersive electrons and address the existence
of excitonic bound states at high temperatures on the semiconductor side of the
semimetal-semiconductor transition. To this end we calculate the imaginary part
of the dynamical electron-hole pair susceptibility and analyze the wave-vector
and energy dependence of excitonic resonances emerging in the band gap. We
thereby confirm the existence of the exciton insulator and its exciton
environment within a generic two-band lattice model with local Coulomb
attraction.Comment: 6 pages, 5 figures, final versio
Space Velocities of L- and T-type Dwarfs
(Abridged) We have obtained radial velocities of a sample of 18 ultracool
dwarfs (M6.5-T8) using high-resolution, near-infrared spectra obtained with
NIRSPEC and the Keck II telescope. We have confirmed that the radial velocity
of Gl 570 D is coincident with that of the K-type primary star Gl 570 A, thus
providing additional support for their true companionship. The presence of
planetary-mass companions around 2MASS J05591914-1404488 (T4.5V) has been
analyzed using five NIRSPEC radial velocity measurements obtained over a period
of 4.37 yr. We have computed UVW space motions for a total of 21 L and T dwarfs
within 20 pc of the Sun. This population shows UVW velocities that nicely
overlap the typical kinematics of solar to M-type stars within the same spatial
volume. However, the mean Galactic (44.2 km/s) and tangential (36.5 km/s)
velocities of the L and T dwarfs appear to be smaller than those of G to M
stars. A significant fraction (~40%) of the L and T dwarfs lies near the Hyades
moving group (0.4-2 Gyr), which contrasts with the 10-12% found for
earlier-type stellar neighbors. Additionally, the distributions of all three
UVW components (sigma_{UVW} = 30.2, 16.5, 15.8 km/s) and the distributions of
the total Galactic (sigma_{v_tot} = 19.1 km/s) and tangential (sigma_{v_t} =
17.6 km/s) velocities derived for the L and T dwarf sample are narrower than
those measured for nearby G, K, and M-type stars, but similar to the
dispersions obtained for F stars. This suggests that, in the solar
neighborhood, the L- and T-type ultracool dwarfs in our sample (including brown
dwarfs) is kinematically younger than solar-type to early M stars with likely
ages in the interval 0.5-4 Gyr.Comment: Accepted for publication in Ap
Hemispheric Asymmetry in New Neurons in Adulthood Is Associated with Vocal Learning and Auditory Memory
Many brain regions exhibit lateral differences in structure and function, and also incorporate new neurons in adulthood, thought to function in learning and in the formation of new memories. However, the contribution of new neurons to hemispheric differences in processing is unknown. The present study combines cellular, behavioral, and physiological methods to address whether 1) new neuron incorporation differs between the brain hemispheres, and 2) the degree to which hemispheric lateralization of new neurons correlates with behavioral and physiological measures of learning and memory. The songbird provides a model system for assessing the contribution of new neurons to hemispheric specialization because songbird brain areas for vocal processing are functionally lateralized and receive a continuous influx of new neurons in adulthood. In adult male zebra finches, we quantified new neurons in the caudomedial nidopallium (NCM), a forebrain area involved in discrimination and memory for the complex vocalizations of individual conspecifics. We assessed song learning and recorded neural responses to song in NCM. We found significantly more new neurons labeled in left than in right NCM; moreover, the degree of asymmetry in new neuron numbers was correlated with the quality of song learning and strength of neuronal memory for recently heard songs. In birds with experimentally impaired song quality, the hemispheric difference in new neurons was diminished. These results suggest that new neurons may contribute to an allocation of function between the hemispheres that underlies the learning and processing of complex signals
Blood pressure, aortic stiffness, hemodynamics and cognition in twin pairs discordant for type 2 diabetes
Background: Type 2 diabetes (T2D) is associated with an increased risk of cognitive impairment and dementia with poorly understood underlying mechanisms. Objective: We examined the role of blood pressure (BP), aortic stiffness, and hemodynamics in this association. Methods: Cross-sectional sample of late middle-aged twins discordant for T2D from the Australian Twin Registry. Measurements included neuropsychological battery and brain MRI including arterial spin labelling (ASL) to measure cerebral perfusion. Mobil-o-Graph devices were used to non-invasively obtain 24-hour BP, aortic stiffness, and hemodynamic measures. Using mixed modelling, we studied associations of T2D with cognition, MRI measures, BP, aortic stiffness, and hemodynamics. Results: There were 23 twin pairs with mean age 63.7 (SD = 6.1) years. T2D (β=-0.45, p < 0.001) and age (β=-0.05, p = 0.022) were independently associated with poorer attention but not with memory or perceptual speed. T2D was associated with reduced nocturnal central systolic BP dipping (β=-3.79, p = 0.027), but not with BP, aortic stiffness, cerebral perfusion, or other hemodynamic measures. There was a statistically significant interaction between T2D and central systolic BP dipping in predicting attention scores (both p < 0.05 for the interaction term) whereby there was a positive association between BP dipping and attention scores in those with T2D, but not in those without T2D. Conclusion: We found an association between T2D and reduced nocturnal central systolic dipping, but not with any other measures of BP, stiffness or hemodynamic measures. Further study of the role of nocturnal central BP dipping in the association between T2D and cognitive impairment may help identify potential mechanisms
Combined Analysis of nu(mu) Disappearance and nu(mu) -\u3e nu(e) Appearance in MINOS Using Accelerator and Atmospheric Neutrinos
We report on a new analysis of neutrino oscillations in MINOS using the complete set of accelerator and atmospheric data. The analysis combines the nu(mu) disappearance and nu(e) appearance data using the three-flavor formalism. We measure vertical bar Delta m(32)(2)vertical bar = [2.28-2.46] x 10(-3) eV(2) (68% C.L.) and sin(2)theta(23) = 0.35-0.65 (90% C.L.) in the normal hierarchy, and vertical bar Delta m(32)(2)vertical bar = [2.32-2.53] x 10(-3) eV(2) (68% C.L.) and sin(2)theta(23) = 0.34-0.67 (90% C.L.) in the inverted hierarchy. The data also constrain delta(CP), the theta(23) octant degeneracy and the mass hierarchy; we disfavor 36% (11%) of this three-parameter space at 68% (90%) C.L
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