Dataplane Specialization for High-performance OpenFlow Software Switching

OpenFlow is an amazingly expressive dataplane program- ming language, but this expressiveness comes at a severe performance price as switches must do excessive packet clas- sification in the fast path. The prevalent OpenFlow software switch architecture is therefore built on flow caching, but this imposes intricate limitations on the workloads that can be supported efficiently and may even open the door to mali- cious cache overflow attacks. In this paper we argue that in- stead of enforcing the same universal flow cache semantics to all OpenFlow applications and optimize for the common case, a switch should rather automatically specialize its dat- aplane piecemeal with respect to the configured workload. We introduce ES WITCH , a novel switch architecture that uses on-the-fly template-based code generation to compile any OpenFlow pipeline into efficient machine code, which can then be readily used as fast path. We present a proof- of-concept prototype and we demonstrate on illustrative use cases that ES WITCH yields a simpler architecture, superior packet processing speed, improved latency and CPU scala- bility, and predictable performance. Our prototype can eas- ily scale beyond 100 Gbps on a single Intel blade even with complex OpenFlow pipelines

Robust concurrent remote entanglement between two superconducting qubits

Entangling two remote quantum systems which never interact directly is an essential primitive in quantum information science and forms the basis for the modular architecture of quantum computing. When protocols to generate these remote entangled pairs rely on using traveling single photon states as carriers of quantum information, they can be made robust to photon losses, unlike schemes that rely on continuous variable states. However, efficiently detecting single photons is challenging in the domain of superconducting quantum circuits because of the low energy of microwave quanta. Here, we report the realization of a robust form of concurrent remote entanglement based on a novel microwave photon detector implemented in the superconducting circuit quantum electrodynamics (cQED) platform of quantum information. Remote entangled pairs with a fidelity of $0.57\pm0.01$ are generated at $200$ Hz. Our experiment opens the way for the implementation of the modular architecture of quantum computation with superconducting qubits.Comment: Main paper: 7 pages, 4 figures; Appendices: 14 pages, 9 figure

A toolkit of mechanism and context independent widgets

Most human-computer interfaces are designed to run on a static platform (e.g. a workstation with a monitor) in a static environment (e.g. an office). However, with mobile devices becoming ubiquitous and capable of running applications similar to those found on static devices, it is no longer valid to design static interfaces. This paper describes a user-interface architecture which allows interactors to be flexible about the way they are presented. This flexibility is defined by the different input and output mechanisms used. An interactor may use different mechanisms depending upon their suitability in the current context, user preference and the resources available for presentation using that mechanism

Deterministic nano-assembly of a coupled quantum emitter - photonic crystal cavity system

The interaction of a single quantum emitter with its environment is a central theme in quantum optics. When placed in highly confined optical fields, such as those created in optical cavities or plasmonic structures, the optical properties of the emitter can change drastically. In particular, photonic crystal (PC) cavities show high quality factors combined with an extremely small mode volume. Efficiently coupling a single quantum emitter to a PC cavity is challenging because of the required positioning accuracy. Here, we demonstrate deterministic coupling of single Nitrogen-Vacancy (NV) centers to high-quality gallium phosphide PC cavities, by deterministically positioning their 50 nm-sized host nanocrystals into the cavity mode maximum with few-nanometer accuracy. The coupling results in a 25-fold enhancement of NV center emission at the cavity wavelength. With this technique, the NV center photoluminescence spectrum can be reshaped allowing for efficient generation of coherent photons, providing new opportunities for quantum science.Comment: 13 pages, 4 figure

Transport of Cytoplasmically Synthesized Proteins into the Mitochondria in a Cell Free System from Neurospora crassa

Synthesis and transport of mitochondrial proteins were followed in a cell-free homogenate of Neurospora crassa in which mitochondrial translation was inhibited. Proteins synthesized on cytoplasmic ribosomes are transferred into the mitochondrial fraction. The relative amounts of proteins which are transferred in vitro are comparable to those transferred in whole cells. Cycloheximide and puromycin inhibit the synthesis of mitochondrial proteins but not their transfer into mitochondria. The transfer of immunoprecipitable mitochondrial proteins was demonstrated for matrix proteins, carboxyatractyloside-binding protein and cytochrome c. Import of proteins into mitochondria exhibits a degree of specificity. The transport mechanism differentiates between newly synthesized proteins and preexistent mitochondrial proteins, at least in the case of matrix proteins. In the cell-free homogenate membrane-bound ribosomes are more active in the synthesis of mitochondrial proteins than are free ribosomes. The finished translation products appear to be released from the membrane-bound ribosomes into the cytosol rather than into the membrane vesicles. The results suggest that the transport of cytoplasmically synthesized mitochondrial proteins is essentially independent of cytoplasmic translation; that cytoplasmically synthesized mitochondrial proteins exist in an extramitochondrial pool prior to import; that the site of this pool is the cytosol for at least some of the mitochondrial proteins; and that the precursors in the extramitochondrial pool differ in structure or conformation from the functional proteins in the mitochondria

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

AbstractRapid modulation of ligand binding affinity (“activation”) is a central property of the integrin cell adhesion receptors. Using a screen for suppressors of integrin activation, we identified the small GTP-binding protein, H-Ras, and its effector kinase, Raf-1, as negative regulators of integrin activation. H-Ras inhibited the activation of integrins with three distinct α and β subunit cytoplasmic domains. Suppression was not associated with integrin phosphorylation and was independent of both mRNA transcription and protein synthesis. Furthermore, suppression correlated with activation of the ERK MAP kinase pathway. Thus, regulation of integrin affinity state is a novel, transcription-independent function of a Ras-linked MAP kinase pathway that may mediate a negative feedback loop in integrin function

Proton Drip-Line Calculations and the Rp-process

One-proton and two-proton separation energies are calculated for proton-rich nuclei in the region $A=41-75$. The method is based on Skyrme Hartree-Fock calculations of Coulomb displacement energies of mirror nuclei in combination with the experimental masses of the neutron-rich nuclei. The implications for the proton drip line and the astrophysical rp-process are discussed. This is done within the framework of a detailed analysis of the sensitivity of rp process calculations in type I X-ray burst models on nuclear masses. We find that the remaining mass uncertainties, in particular for some nuclei with $N=Z$, still lead to large uncertainties in calculations of X-ray burst light curves. Further experimental or theoretical improvements of nuclear mass data are necessary before observed X-ray burst light curves can be used to obtain quantitative constraints on ignition conditions and neutron star properties. We identify a list of nuclei for which improved mass data would be most important.Comment: 20 pages, 9 figures, 2 table