407 research outputs found
Cardiovascular Benefits of GLP-1-BasedTherapies in Patients with Diabetes Mellitus Type 2: Effects on Endothelial and Vascular Dysfunction beyond Glycemic Control
Type 2 diabetes mellitus (T2DM) is a progressive multisystemic disease accompanied by vascular dysfunction and a tremendous increase in cardiovascular mortality. Numerous adipose-tissue-derived factors and beta cell dysfunction contribute to the increased cardiovascular risk in patients with T2DM. Nowadays, numerous pharmacological interventions are available to lower blood glucose levels in patients with type 2 diabetes. Beside more or less comparable glucose lowering efficacy, some of them have shown limited or probably even unfavorable effects on the cardiovascular system and overall mortality. Recently, incretin-based therapies (GLP-1 receptor agonists and DPP-IV inhibitors) have been introduced in the treatment of T2DM. Beside the effects of GLP-1 on insulin secretion, glucagon secretion, and gastrointestinal motility, recent studies suggested a couple of direct cardiovascular effects of GLP-1-based therapies. The goal of this paper is to provide an overview about the current knowledge of direct GLP-1 effects on endothelial and vascular function and potential consequences on the cardiovascular outcome in patients with T2DM treated with GLP-1 receptor agonists or DPP-IV inhibitors
Radiative orbital electron capture by the atomic nucleus
The rate for the photon emission accompanying orbital 1S electron capture by
the atomic nucleus is recalculated. While a photon can be emitted by the
electron or by the nucleus, the use of the length gauge significantly
suppresses the nuclear contribution. Our calculations resolve the long standing
discrepancy of theoretical predictions with experimental data for
forbidden transitions. We illustrate the results by comparison with the data
established experimentally for the first forbidden unique decays of Ca
and Tl.Comment: 18 pages, 2 figures, submitted to Phys. Rev.
Radiative electron capture in the first forbidden unique decay of 81Kr
The photon spectrum accompanying the orbital K-electron capture in the first
forbidden unique decay of 81Kr was measured. The total radiation intensity for
the photon energies larger than 50 keV was found to be 1.47(6) x 10^{-4} per
K-capture. Both the shape of the spectrum and its intensity relative to the
ordinary, non-radiative capture rate, are compared to theoretical predictions.
The best agreement is found for the recently developed model which employs the
length gauge for the electromagnetic field.Comment: 7 pages, 6 figure
Beta decay of 71,73Co; probing single particle states approaching doubly magic 78Ni
Low-energy excited states in 71,73Ni populated via the {\beta} decay of
71,73Co were investigated in an experiment performed at the National
Superconducting Cyclotron Laboratory (NSCL) at Michigan State University (MSU).
Detailed analysis led to the construction of level schemes of 71,73Ni, which
are interpreted using systematics and analyzed using shell model calculations.
The 5/2- states attributed to the the f5/2 orbital and positive parity 5/2+ and
7/2+ states from the g9/2 orbital have been identified in both 71,73Ni. In 71Ni
the location of a 1/2- {\beta}-decaying isomer is proposed and limits are
suggested as to the location of the isomer in 73Ni. The location of positive
parity cluster states are also identified in 71,73Ni. Beta-delayed neutron
branching ratios obtained from this data are given for both 71,73Co.Comment: Accepted for publication in PR
First observation of 54Zn and its decay by two-proton emission
The nucleus 54Zn has been observed for the first time in an experiment at the
SISSI/LISE3 facility of GANIL in the quasi-fragmentation of a 58Ni beam at 74.5
MeV/nucleon in a natNi target. The fragments were analysed by means of the
ALPHA-LISE3 separator and implanted in a silicon-strip detector where
correlations in space and time between implantation and subsequent decay events
allowed us to generate almost background free decay spectra for about 25
different nuclei at the same time. Eight 54Zn implantation events were
observed. From the correlated decay events, the half-life of 54Zn is determined
to be 3.2 +1.8/-0.8 ms. Seven of the eight implantations are followed by
two-proton emission with a decay energy of 1.48(2) MeV. The decay energy and
the partial half-life are compared to model predictions and allow for a test of
these two-proton decay models.Comment: 4 pages, 4 figures, accepted for publication in PR
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