Interaction-free measurements by quantum Zeno stabilisation of ultracold atoms

Quantum mechanics predicts that our physical reality is influenced by events that can potentially happen but factually do not occur. Interaction-free measurements (IFMs) exploit this counterintuitive influence to detect the presence of an object without requiring any interaction with it. Here we propose and realize an IFM concept based on an unstable many-particle system. In our experiments, we employ an ultracold gas in an unstable spin configuration which can undergo a rapid decay. The object - realized by a laser beam - prevents this decay due to the indirect quantum Zeno effect and thus, its presence can be detected without interacting with a single atom. Contrary to existing proposals, our IFM does not require single-particle sources and is only weakly affected by losses and decoherence. We demonstrate confidence levels of 90%, well beyond previous optical experiments.Comment: manuscript with 5 figures, 3 supplementary figure, 1 supplementary not

Satisfying the Einstein-Podolsky-Rosen criterion with massive particles

In 1935, Einstein, Podolsky and Rosen (EPR) questioned the completeness of quantum mechanics by devising a quantum state of two massive particles with maximally correlated space and momentum coordinates. The EPR criterion qualifies such continuous-variable entangled states, where a measurement of one subsystem seemingly allows for a prediction of the second subsystem beyond the Heisenberg uncertainty relation. Up to now, continuous-variable EPR correlations have only been created with photons, while the demonstration of such strongly correlated states with massive particles is still outstanding. Here, we report on the creation of an EPR-correlated two-mode squeezed state in an ultracold atomic ensemble. The state shows an EPR entanglement parameter of 0.18(3), which is 2.4 standard deviations below the threshold 1/4 of the EPR criterion. We also present a full tomographic reconstruction of the underlying many-particle quantum state. The state presents a resource for tests of quantum nonlocality and a wide variety of applications in the field of continuous-variable quantum information and metrology.Comment: 8 pages, 7 figure

0.75 atoms improve the clock signal of 10,000 atoms

Since the pioneering work of Ramsey, atom interferometers are employed for precision metrology, in particular to measure time and to realize the second. In a classical interferometer, an ensemble of atoms is prepared in one of the two input states, whereas the second one is left empty. In this case, the vacuum noise restricts the precision of the interferometer to the standard quantum limit (SQL). Here, we propose and experimentally demonstrate a novel clock configuration that surpasses the SQL by squeezing the vacuum in the empty input state. We create a squeezed vacuum state containing an average of 0.75 atoms to improve the clock sensitivity of 10,000 atoms by 2.05 dB. The SQL poses a significant limitation for today's microwave fountain clocks, which serve as the main time reference. We evaluate the major technical limitations and challenges for devising a next generation of fountain clocks based on atomic squeezed vacuum.Comment: 9 pages, 6 figure

Insulating Behavior of a Trapped Ideal Fermi Gas

We investigate theoretically and experimentally the center-of-mass motion of an ideal Fermi gas in a combined periodic and harmonic potential. We find a crossover from a conducting to an insulating regime as the Fermi energy moves from the first Bloch band into the bandgap of the lattice. The conducting regime is characterized by an oscillation of the cloud about the potential minimum, while in the insulating case the center of mass remains on one side of the potential.Comment: 4 pages, 4 figure

Tunneling of polarized fermions in 3D double wells

We study the tunneling of a spin polarized Fermi gas in a three-dimensional double well potential, focusing on the time dynamics starting from an initial state in which there is an imbalance in the number of particles in the two wells. Although fermions in different doublets of the double well tunnel with different frequencies, we point out that (incoherent) oscillations of a large number of particles can arise, as a consequence of the presence of transverse degrees of freedom. Estimates of the doublet structure and of the occupation of transverse eigenstates for a realistic experimental setup are provided.Comment: 10 pages, Typos corrected and figures changed - published in Laser Physics, issue on the LPHYS'11 conference (Sarajevo, 2011

Dipole Oscillations of a Fermi Gas in a Disordered Trap: Damping and Localization

We theoretically study the dipole oscillations of an ideal Fermi gas in a disordered trap. We show that even weak disorder induces strong damping of the oscillations and we identify a metal-insulator crossover. For very weak disorder, we show that damping results from a dephasing effect related to weak random perturbations of the energy spectrum. For increasing disorder, we show that the Fermi gas crosses over to an insulating regime characterized by strong-damping due to the proliferation of localized states.Comment: published as EPL 88 (2009) 3000

po 290 etv7 regulates breast cancer stem cells content and chemoresistance

Introduction Cancer stem cells (CSCs) are considered the population of cells within the tumour able to drive tumorigenesis and known to be highly resistant to conventional chemotherapy. ETV7 is a poorly studied transcription factor member of ETS large family, known to be an interferon-stimulated gene. It has been recently found over-expressed in breast cancer (BC), with higher expression levels in the more aggressive BC subtypes. In this work, we investigated the effects of ETV7 increased expression on breast CSCs population and resistance to chemotherapy in BC cells. Material and methods We generated MCF7 and T47D BC-derived cells stably over-expressing ETV7 and obtained ETV7 KO in MDA-MB-231 BC cells using CRISPR/Cas9 technology. We analysed breast CSCs content via CD44/CD24 staining and FACS analysis, as well as mammospheres formation assay. We measured expression of ABC transporters and anti-apoptotic proteins via RT-qPCR and western blot. We finally assessed sensitivity to Doxorubicin and 5-Fluorouracil (5-FU) via MTT assay and AnnexinV/PI staining at FACS. Results and discussions We observed that the expression of ETV7 could be induced by various stimuli, particularly by chemotherapeutic drugs able to induce DNA damage. We then analysed the impact of ETV7 expression on the sensitivity to Doxorubicin and 5-FU and we could observe a significantly decreased sensitivity to these drugs upon ETV7 over-expression. We could also appreciate an increase in ABC transporters and BCL2 anti-apoptotic protein expression following ETV7 over-expression. We further observed that alteration of ETV7 expression could significantly affect the population of breast cancer stem cells (CD44+/CD24low cells) in different BC cell lines. Conclusion We propose a novel role for ETV7 in breast cancer stem cells plasticity and associated resistance to conventional chemotherapy. We finally suggest that an in-depth investigation of this mechanism could lead to novel breast CSCs targeted therapies and to the improvement of combinatorial regimens with the aim of avoiding resistance and relapse in breast cancer

Learning Quantum Systems

Quantum technologies hold the promise to revolutionise our society with ground-breaking applications in secure communication, high-performance computing and ultra-precise sensing. One of the main features in scaling up quantum technologies is that the complexity of quantum systems scales exponentially with their size. This poses severe challenges in the efficient calibration, benchmarking and validation of quantum states and their dynamical control. While the complete simulation of large-scale quantum systems may only be possible with a quantum computer, classical characterisation and optimisation methods (supported by cutting edge numerical techniques) can still play an important role. Here, we review classical approaches to learning quantum systems, their correlation properties, their dynamics and their interaction with the environment. We discuss theoretical proposals and successful implementations in different physical platforms such as spin qubits, trapped ions, photonic and atomic systems, and superconducting circuits. This review provides a brief background for key concepts recurring across many of these approaches, such as the Bayesian formalism or Neural Networks, and outlines open questions

Towards Practical Runtime Verification and Validation of Self-Adaptive Software Systems

International audienceSoftware validation and verification (V&V) ensures that software products satisfy user requirements and meet their expected quality attributes throughout their lifecycle. While high levels of adaptation and autonomy provide new ways for software systems to operate in highly dynamic environments, developing certifiable V&V methods for guaranteeing the achievement of self-adaptive software goals is one of the major challenges facing the entire research field. In this chapter we (i) analyze fundamental challenges and concerns for the development of V&V methods and techniques that provide certifiable trust in self-adaptive and self-managing systems; and (ii) present a proposal for including V&V operations explicitly in feedback loops for ensuring the achievement of software self-adaptation goals. Both of these contributions provide valuable starting points for V&V researchers to help advance this field

Converting multilevel nonclassicality into genuine multipartite entanglement

Characterizing genuine quantum resources and determining operational rules for their manipulation are crucial steps to appraise possibilities and limitations of quantum technologies. Two such key resources are nonclassicality, manifested as quantum superposition between reference states of a single system, and entanglement, capturing quantum correlations among two or more subsystems. Here we present a general formalism for the conversion of nonclassicality into multipartite entanglement, showing that a faithful reversible transformation between the two resources is always possible within a precise resource-theoretic framework. Specializing to quantum coherence between the levels of a quantum system as an instance of nonclassicality, we introduce explicit protocols for such a mapping. We further show that the conversion relates multilevel coherence and multipartite entanglement not only qualitatively, but also quantitatively, restricting the amount of entanglement achievable in the process and in particular yielding an equality between the two resources when quantified by fidelity-based geometric measures