Combining a Click–Multicomponent Reaction: One-Pot Synthesis of 1,2,3-Triazol-4-ylmethyl 3-Amino-5,10-dihydro-5,10-dioxo-1<i>H</i>-pyrazolo[1,2-<i>b</i>]phthalazine-2-carboxylate Derivatives

<div><p></p><p>(1,2,3-Triazol-4-yl)methyl-3-amino-5,10-dihydro-5,10-dioxo-1<i>H</i>-pyrazolo[1,2-<i>b</i>]phthalazine-2-carboxylate derivatives were synthesized by a four-component, one-pot condensation reaction of benzaldehyde derivatives, an active methylene compound (prop-2-ynyl-2-cyanoacetate), azides, and phthalhydrazide in the presence of Cu(OAc)₂/sodium ascorbate as catalysts and 1-methyl-1<i>H</i>-imidazolium trifluoroacetate ([Hmim]TFA) as an ionic liquid medium in good to excellent yields.</p> </div

A nor-diterpene from <i>Salvia sahendica</i> leaves

<p>Phytochemical investigation of <i>n</i>-hexane extract of <i>Salvia sahendica</i> by normal phase column chromatography resulted in the isolation of six compounds. Structures were established by 1D and 2D NMR spectroscopy, and HRMS, as a new norditerpene <b>1</b>, and known terpenoids, sclareol (<b>2</b>), oleanolic acid (<b>3</b>), β-sitosterol (<b>4</b>), salvigenin (<b>5</b>) and 3<i>α</i>-hydroxy-11<i>α</i>,12<i>α</i>-epoxyoleanan-28,13<i>β</i>-olide (<b>6</b>). The absolute configuration of <b>1</b> was confirmed by a combination of X-ray single crystal analysis and electronic circular dichroism spectroscopy. <i>In vitro</i> cytotoxic activity on breast cancer cell line (MDA-MB-231) and also the antimicrobial activity of the pure compounds were tested against <i>Staphylococcus aureus</i>, <i>Bacilus cereus</i> and <i>Escherichia coli</i>.</p

Escritura pública de declaración de [...] de localidades, [...] de esta y del Convenio con los accionistas otorgada por la Comisión Directiva del Teatre del Liceo y reglamento de mismo ante Francisco Javier Moreu, notario, 31 de marzo de 1851

A new triterpenoid, urmiensolide (<b>1</b>), was isolated from <i>Salvia urmiensis</i>. The structure was elucidated by a combination of 1D and 2D NMR, HRESIMS, and X-ray crystallographic analyses. The absolute configuration was established by comparison of experimental and simulated ECD spectra. Urmiensolide is the first pentacyclic triterpenoid bearing a ε-lactone E-ring. The compound showed in vitro antitrypanosoal activity with an IC₅₀ value of 5.6 μM against the <i>Trypanosoma brucei rhodesiense</i> STIB 900 strain and a selectivity index of 33. A possible biosynthetic pathway of <b>1</b> from α-amyrin is proposed