Escritura pública de declaración de [...] de localidades, [...] de esta y del Convenio con los accionistas otorgada por la Comisión Directiva del Teatre del Liceo y reglamento de mismo ante Francisco Javier Moreu, notario, 31 de marzo de 1851

Abstract

A new triterpenoid, urmiensolide (<b>1</b>), was isolated from <i>Salvia urmiensis</i>. The structure was elucidated by a combination of 1D and 2D NMR, HRESIMS, and X-ray crystallographic analyses. The absolute configuration was established by comparison of experimental and simulated ECD spectra. Urmiensolide is the first pentacyclic triterpenoid bearing a ε-lactone E-ring. The compound showed in vitro antitrypanosoal activity with an IC₅₀ value of 5.6 μM against the <i>Trypanosoma brucei rhodesiense</i> STIB 900 strain and a selectivity index of 33. A possible biosynthetic pathway of <b>1</b> from α-amyrin is proposed