ZERO ELECTRIC ENERGY ISLAND CONCEPT IN CROATIA – PRELIMINARY STUDY FOR THE ISLAND OF VIS

Hrvatski otoci, s jakim prirodnim potencijalom vjetra i Sunca, moguće su lokacije za intenzivnu uporabu obnovljivih izvora energije. U ovom su radu predstavljeni rezultati preliminarnog istraživanja mogućnosti izvedbe koncepta električno nezavisnog otoka uporabom isključivo obnovljivih izvora energije. Istraživanje je provedeno za otok Vis.Croatian islands, with strong natural wind and solar potential, are possible locations for extensive usage of renewable energy sources. This paper presents the results of the preliminary investigation of the applicability of renewable energy sources for the zero-energy island concept on Croatian islands, in particular for the central Dalmatian island of Vis

Recent developments in genetics and medically assisted reproduction : from research to clinical applications

Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.Peer reviewe

ZERO ELECTRIC ENERGY ISLAND CONCEPT IN CROATIA – PRELIMINARY STUDY FOR THE ISLAND OF VIS

Hrvatski otoci, s jakim prirodnim potencijalom vjetra i Sunca, moguće su lokacije za intenzivnu uporabu obnovljivih izvora energije. U ovom su radu predstavljeni rezultati preliminarnog istraživanja mogućnosti izvedbe koncepta električno nezavisnog otoka uporabom isključivo obnovljivih izvora energije. Istraživanje je provedeno za otok Vis.Croatian islands, with strong natural wind and solar potential, are possible locations for extensive usage of renewable energy sources. This paper presents the results of the preliminary investigation of the applicability of renewable energy sources for the zero-energy island concept on Croatian islands, in particular for the central Dalmatian island of Vis

Quinoxaline-2-carboxamide as a carrier ligand in two new platinum(ii) compounds: Synthesis, crystal structure, cytotoxic activity and DNA interaction

The search for platinum compounds structurally different from cisplatin has led to two new platinum(II) compounds containing quinoxaline-2-carboxamide as a carrier ligand, i.e. cis-[Pt(qnxca)(MeCN)Cl2] (1) and the [Pt(qnxca−H)(dmso)Cl] (2). Both compounds have been synthesized and characterized using different spectroscopic methods. In addition, single-crystal structures have been determined by X-Ray diffraction for both compounds. In each case a square planar Pt(II) is present; in (1) the qnxca is monodentate and neutral, whereas in (2) the ligand has lost a hydrogen, to form the anionic chelating ligand abbreviated as qnxca−H. The biological activity of both compounds has been investigated in a panel of seven human tumour cells, displaying poor cytotoxic activity, compared to cisplatin. The interaction of the new compounds with 1 or 2 equiv. of 9-ethylguanine has been studied using 1H NMR, 195Pt NMR and ESI-MS spectroscopy, finding poor reactivity of 1 towards the model base, forming only the monosubstituted adduct. Surprisingly, compound 2, which is more sterically crowded, interacts more efficiently with the 9-EtG, forming a bifunctional adduct with two 9-EtG with substitution of the dmso and the chloride ligand. Unwinding studies of pUC19 plasmid DNA by compound 1 show similar unwinding properties to cisplatin